INT45159

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Context Info
Confidence 0.54
First Reported 1983
Last Reported 2010
Negated 3
Speculated 5
Reported most in Abstract
Documents 16
Total Number 23
Disease Relevance 13.57
Pain Relevance 4.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Nppb) extracellular region (Nppb) nucleus (Nppb)
cytoplasm (Nppb)
Anatomy Link Frequency
coronary artery 2
plasma 2
brain 2
Nppb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 96 100.00 Very High Very High Very High
Inflammation 47 100.00 Very High Very High Very High
Pain 8 100.00 Very High Very High Very High
ischemia 7 99.98 Very High Very High Very High
Neuropeptide 1 99.92 Very High Very High Very High
Desipramine 8 99.52 Very High Very High Very High
agonist 3 99.40 Very High Very High Very High
imagery 37 99.00 Very High Very High Very High
antagonist 10 98.68 Very High Very High Very High
GABA receptor 2 97.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 106 100.00 Very High Very High Very High
Rheumatoid Arthritis 96 100.00 Very High Very High Very High
Cardiovascular Disease 83 100.00 Very High Very High Very High
Natriuresis 70 100.00 Very High Very High Very High
INFLAMMATION 51 100.00 Very High Very High Very High
Renal Disease 13 100.00 Very High Very High Very High
Pain 4 100.00 Very High Very High Very High
Cv Unclassified Under Development 9 99.98 Very High Very High Very High
Hypoxia 146 99.68 Very High Very High Very High
Coronary Artery Disease 32 99.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One possible reason for the lack of significant change in BNP levels might be the relatively short period of exposure to the hypobaric hypoxic conditions.
Regulation (change) of BNP associated with hypoxia
1) Confidence 0.54 Published 2010 Journal Indian Journal of Ophthalmology Section Body Doc Link PMC2886248 Disease Relevance 1.46 Pain Relevance 0
The action of ANP, BNP and related peptides on motivated behavior in rats.
Regulation (action) of BNP associated with neuropeptide
2) Confidence 0.41 Published 1994 Journal Rev Neurosci Section Title Doc Link 7697199 Disease Relevance 0.57 Pain Relevance 0.28
In the present study, we report a novel function of BNP in pain modulation.
Regulation (modulation) of BNP associated with pain
3) Confidence 0.39 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20702721 Disease Relevance 0.84 Pain Relevance 0.51
As a control, NT-proBNP at baseline and end-of-treatment was determined in two other patients participating in the same clinical trial and who had similar exposure to bortezomib and chemotherapy.
Regulation (control) of NT-proBNP
4) Confidence 0.26 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1475607 Disease Relevance 0.26 Pain Relevance 0
Plasma BNP levels did not change after short-term hypobaric hypoxic exposure, while the IOP increased.
Neg (not) Regulation (change) of BNP in Plasma associated with hypoxia and ocular hypertension
5) Confidence 0.24 Published 2010 Journal Indian Journal of Ophthalmology Section Abstract Doc Link PMC2886248 Disease Relevance 1.13 Pain Relevance 0
With these findings in mind, we hypothesized that under hypobaric hypoxic conditions, endogenous BNP might serve to compensate the rise in IOP resulting from exposure to these conditions, because we were anticipating a significant change in BNP due to hypoxia.
Regulation (change) of BNP associated with hypoxia and ocular hypertension
6) Confidence 0.24 Published 2010 Journal Indian Journal of Ophthalmology Section Body Doc Link PMC2886248 Disease Relevance 1.40 Pain Relevance 0
However, after adjusting for these confounding factors, we found that the prognostic value of BNP and hsCRP were still statistically significant.
Regulation (value) of BNP
7) Confidence 0.24 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2628862 Disease Relevance 0.50 Pain Relevance 0.07
The suppressing effect of clonidine was antagonized by the pretreatment with yohimbine at a dose which did not affect the duration of immobility, when given alone, nor influenced the action of DMI, whereas the effect of ISO was not affected by the same dose of yohimbine.
Neg (not) Regulation (affected) of ISO associated with desipramine and clonidine
8) Confidence 0.24 Published 1983 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 6632384 Disease Relevance 0 Pain Relevance 0.73
We investigated the change in NT-proBNP levels over time and examined associations between measures of inflammation, RA disease activity, medication taken, known CVD risk factors, and NT-proBNP (dependent variable).
Spec (investigated) Regulation (change) of NT-proBNP associated with inflammation, cardiovascular disease, rheumatoid arthritis and disease
9) Confidence 0.23 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483462 Disease Relevance 0.69 Pain Relevance 0.10
NT-proBNP levels were dichotomized according to the national gender- and age-adjusted reference levels modified from Roche Diagnostics guidelines [22] (female: < 50 years of age, NT-proBNP ?
Regulation (modified) of NT-proBNP
10) Confidence 0.23 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483462 Disease Relevance 0.36 Pain Relevance 0.16
We investigated the change in NT-proBNP levels over time and examined associations between measures of inflammation, RA disease activity, medication taken, known CVD risk factors, and NT-proBNP (dependent variable).
Spec (investigated) Regulation (change) of NT-proBNP associated with inflammation, cardiovascular disease, rheumatoid arthritis and disease
11) Confidence 0.23 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483462 Disease Relevance 0.66 Pain Relevance 0.10
These findings strongly suggest that the discrepancies between the marked effects of BNP (a partial mu agonist and kappa antagonist) and PTZ (a mu antagonist and kappa agonist) on rCMRglc reflect the selectivity of agonist action at the different types of opioid receptors, mu and kappa receptors, in the rat brain.
Regulation (effects) of BNP in brain associated with antagonist, agonist and opioid receptor
12) Confidence 0.23 Published 1997 Journal Biol. Pharm. Bull. Section Abstract Doc Link 9331984 Disease Relevance 0 Pain Relevance 0.74
A putative clearance receptor, NPR-C, is believed to regulate cardiac levels of ANP and BNP.
Regulation (regulate) of BNP in BNP
13) Confidence 0.21 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16272201 Disease Relevance 0.88 Pain Relevance 0.22
The 'anxiolytic-like' effects of a BNP were not modulated by a dopaminergic blocker, an alpha-adrenoreceptor antagonist, a GABA receptor antagonist, a 5-HT receptor antagonist or an opiate antagonist.
Neg (not) Regulation (modulated) of BNP associated with gaba receptor, antagonist, anxiety disorder and opiate
14) Confidence 0.19 Published 1996 Journal Neuropeptides Section Abstract Doc Link 8868301 Disease Relevance 0.72 Pain Relevance 0.68
[Peculiarities of dynamics and prognostic value of NT-proBNP level in different variants of treatment of patients with acute coronary syndrome].
Regulation (value) of NT-proBNP associated with acute coronary syndrome
15) Confidence 0.18 Published 2010 Journal Kardiologiia Section Title Doc Link 20146673 Disease Relevance 0.31 Pain Relevance 0.13
These include tests for the presence of acute inflammation and infiltration (e.g., high sensitivity-C-reactive protein, myeloperoxidase), plaque instability (e.g., pregnancy-associated plasma protein-A, placental growth factor), platelet activation (e.g., whole blood choline, platelet density, CD40 ligand), and myocardial ischemia (e.g., ischemia modified albumin, free fatty acids, serum choline, and B-type natriuretic peptide).
Regulation (modified) of B-type natriuretic peptide in plasma associated with natriuresis, coronary artery disease, inflammation and ischemia
16) Confidence 0.03 Published 2005 Journal Scand. J. Clin. Lab. Invest. Suppl. Section Abstract Doc Link 16112968 Disease Relevance 1.13 Pain Relevance 0.22
OBJECTIVE: We aimed to investigate the value of N-terminal pro-Brain Natriuretic Peptide (NT-proBNP) in combination with tissue Doppler imaging (TDI) to predict the presence of significant coronary artery (CAD) in patients with conventionally normal systolic and diastolic function.
Spec (investigate) Regulation (value) of N-terminal pro-Brain Natriuretic Peptide in coronary artery associated with natriuresis, coronary artery disease and imagery
17) Confidence 0.02 Published 2006 Journal Anadolu Kardiyol Derg Section Abstract Doc Link 16943107 Disease Relevance 0.35 Pain Relevance 0.12
OBJECTIVE: We aimed to investigate the value of N-terminal pro-Brain Natriuretic Peptide (NT-proBNP) in combination with tissue Doppler imaging (TDI) to predict the presence of significant coronary artery (CAD) in patients with conventionally normal systolic and diastolic function.
Spec (investigate) Regulation (value) of NT-proBNP in coronary artery associated with natriuresis, coronary artery disease and imagery
18) Confidence 0.02 Published 2006 Journal Anadolu Kardiyol Derg Section Abstract Doc Link 16943107 Disease Relevance 0.35 Pain Relevance 0.12
Higher CRP and NT-proBNP values were also associated with 2.5-fold to 5.4-fold increased risk of secondary endpoints including AMI, pulmonary oedema, and primary cardiovascular death (p<0.05), whereas higher RCRI was not associated with AMI or primary cardiovascular death (table 4).
Regulation (values) of NT-proBNP associated with heart rate under development and death
19) Confidence 0.01 Published 2010 Journal Heart Section Body Doc Link PMC2791233 Disease Relevance 0.46 Pain Relevance 0
Logarithmically transformed values of NT-proBNP and CRP were also used to minimise distribution skewness and kurtosis.
Regulation (values) of NT-proBNP
20) Confidence 0.01 Published 2010 Journal Heart Section Body Doc Link PMC2791233 Disease Relevance 0.65 Pain Relevance 0

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