INT45167

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Context Info
Confidence 0.60
First Reported 1983
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 32
Total Number 38
Disease Relevance 17.09
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ASAP1) cytoplasm (ASAP1)
Anatomy Link Frequency
lung 4
pulmonary artery 2
ventricle 1
mitral valve 1
HIP 1
ASAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 2 99.96 Very High Very High Very High
lidocaine 11 98.28 Very High Very High Very High
imagery 12 97.24 Very High Very High Very High
Paracetamol 17 95.20 Very High Very High Very High
antagonist 6 88.24 High High
Pain 16 85.32 High High
Dopamine 24 83.52 Quite High
Infliximab 1 78.44 Quite High
local anesthetic 10 75.00 Quite High
cytokine 19 74.80 Quite High
Disease Link Frequency Relevance Heat
Pulmonary Alveolar Proteinosis 235 100.00 Very High Very High Very High
Pressure And Volume Under Development 14 100.00 Very High Very High Very High
Pancreatitis 6 99.96 Very High Very High Very High
Dyspnea 15 99.90 Very High Very High Very High
Carcinoma 2 99.78 Very High Very High Very High
High Cardiac Output 5 99.68 Very High Very High Very High
Osteoporosis 2 99.60 Very High Very High Very High
Hypertension 70 99.40 Very High Very High Very High
Sarcoidosis 73 99.22 Very High Very High Very High
Infection 50 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whether prenatal care represents the best opportunity to increase Pap testing is a source of controversy.
Positive_regulation (increase) of Pap
1) Confidence 0.60 Published 2008 Journal Prev Chronic Dis Section Body Doc Link PMC2578779 Disease Relevance 0.46 Pain Relevance 0
Increased efforts may be needed to discuss with Mexico's policy makers, physicians, and public health community whether prenatal care is the best opportunity to increase lifetime Pap testing prevalence and help to achieve the Healthy Border 2010 goal of a 20% reduction in cancer mortality (12).


Positive_regulation (increase) of Pap associated with cancer
2) Confidence 0.60 Published 2008 Journal Prev Chronic Dis Section Body Doc Link PMC2578779 Disease Relevance 0.47 Pain Relevance 0
Our patient represents, with respect to many features, an original clinical case of prostate carcinoma occurring in young age, for the atypical association of an undifferentiated carcinoma with high levels of PSA and PAP and with osteoblastic-pattern of bone metastases.
Positive_regulation (levels) of PAP associated with osteoporosis, carcinoma, prostate cancer and metastasis
3) Confidence 0.59 Published 2000 Journal Clin Ter Section Abstract Doc Link 11141722 Disease Relevance 1.04 Pain Relevance 0
Notably, surfactant accumulation in PAP is associated with certain infections and with inhalation of some particulates.
Positive_regulation (accumulation) of PAP associated with pulmonary alveolar proteinosis and infection
4) Confidence 0.43 Published 2008 Journal Respir Res Section Body Doc Link PMC2265287 Disease Relevance 1.19 Pain Relevance 0
Respondents who reported receiving at least 1 Pap test were asked, "Why did you have your most recent Pap smear test?"
Positive_regulation (receiving) of Pap
5) Confidence 0.43 Published 2008 Journal Prev Chronic Dis Section Body Doc Link PMC2578779 Disease Relevance 0.13 Pain Relevance 0
Respondents who reported receiving at least 1 Pap test were asked, "Why did you have your most recent Pap smear test?"
Positive_regulation (recent) of Pap
6) Confidence 0.43 Published 2008 Journal Prev Chronic Dis Section Body Doc Link PMC2578779 Disease Relevance 0.24 Pain Relevance 0
In order to rule out the possibility that SULT4A1 simply has a much weaker affinity for PAP, we performed titration experiments for several of the proteins with increasing concentrations of PAP ranging from 90 ?
Positive_regulation (concentrations) of PAP
7) Confidence 0.41 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0 Pain Relevance 0
SULT1C2-PAP-PCP complex was crystallized using the sitting drop method at 20 °C by mixing 0.8 ?
Positive_regulation (crystallized) of PAP
8) Confidence 0.41 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0 Pain Relevance 0
These data suggest that an opportunity to increase lifetime Pap test prevalence is being missed in Matamoros.
Positive_regulation (increase) of Pap
9) Confidence 0.40 Published 2008 Journal Prev Chronic Dis Section Body Doc Link PMC2578779 Disease Relevance 0.40 Pain Relevance 0
This study identifies a large disparity in Pap testing between women who delivered in Matamoros and those who delivered in Cameron County and suggests that prenatal care is a valuable opportunity to increase Pap test coverage.
Positive_regulation (increase) of Pap
10) Confidence 0.40 Published 2008 Journal Prev Chronic Dis Section Body Doc Link PMC2578779 Disease Relevance 0 Pain Relevance 0
With increasing numbers of women in obstetric practice (31-33), this barrier may not be as significant in the prenatal population and may contribute to the increased prevalence of lifetime Pap testing in this study population.
Positive_regulation (increased) of Pap
11) Confidence 0.40 Published 2008 Journal Prev Chronic Dis Section Body Doc Link PMC2578779 Disease Relevance 0.61 Pain Relevance 0.09
For example, resveratrol was a substrate for SULT1A3 and SULT1C2, but did not stabilize either protein in the binding assays, either in the presence or absence of PAP.
Neg (not) Positive_regulation (stabilize) of PAP
12) Confidence 0.38 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0 Pain Relevance 0.04
Furthermore, PAP measurement without flow information can be misleading especially in cases with elevated PAP due to high cardiac output but normal pulmonary vascular resistance (PVR).
Positive_regulation (elevated) of PAP associated with high cardiac output
13) Confidence 0.38 Published 2010 Journal Int J Cardiovasc Imaging Section Body Doc Link PMC2868165 Disease Relevance 1.25 Pain Relevance 0
The involvement of HIP/PAP in the pathophysiology of IC is suggested.


Positive_regulation (involvement) of PAP in HIP
14) Confidence 0.37 Published 2010 Journal Urology Section Body Doc Link 19646740 Disease Relevance 0.06 Pain Relevance 0
Pancreatitis-associated protein (PAP), an acute-phase protein, is dramatically upregulated during acute and chronic pancreatitis.
Positive_regulation (upregulated) of PAP associated with chronic pancreatitis
15) Confidence 0.35 Published 2009 Journal Pancreatology Section Abstract Doc Link 19077460 Disease Relevance 0.47 Pain Relevance 0.20
Tissue Doppler derived isovolumetric relaxation time (IVRT’) of the right ventricle (RV) predicts elevated PAP in humans [14].
Positive_regulation (elevated) of PAP in ventricle
16) Confidence 0.33 Published 2010 Journal Int J Cardiovasc Imaging Section Body Doc Link PMC2868165 Disease Relevance 0.96 Pain Relevance 0
Invasive TPVR was calculated using the previous formula and the mean PAP was derived from systolic PAP using previously validated formula [24], and Bland–Altman plot between Echo-TPVR formula-2 and invasive TPVR measurement (c)Fig. 3Correlation between invasive (right heart catheterization) measurement of PAP and its estimation from echocardiographically derived pulmonary artery acceleration time (a) and pulmonary artery deceleration (b)
Positive_regulation (measurement) of PAP in heart
17) Confidence 0.27 Published 2010 Journal Int J Cardiovasc Imaging Section Body Doc Link PMC2868165 Disease Relevance 0.13 Pain Relevance 0
A comparison of echocardiography to invasive measurement in the evaluation of pulmonary arterial hypertension in a rat model

Pulmonary arterial hypertension (PAH) is a life-threatening condition characterized by progressive elevation in pulmonary artery pressure (PAP) and total pulmonary vascular resistance (TPVR).

Positive_regulation (elevation) of PAP in pulmonary artery associated with pulmonary hypertension
18) Confidence 0.22 Published 2010 Journal Int J Cardiovasc Imaging Section Title Doc Link PMC2868165 Disease Relevance 0.66 Pain Relevance 0.05
Invasive TPVR was calculated using the previous formula and the mean PAP was derived from systolic PAP using previously validated formula [24], and Bland–Altman plot between Echo-TPVR formula-2 and invasive TPVR measurement (c)Fig. 3Correlation between invasive (right heart catheterization) measurement of PAP and its estimation from echocardiographically derived pulmonary artery acceleration time (a) and pulmonary artery deceleration (b)
Positive_regulation (derived) of PAP in pulmonary artery
19) Confidence 0.22 Published 2010 Journal Int J Cardiovasc Imaging Section Body Doc Link PMC2868165 Disease Relevance 0.15 Pain Relevance 0
Previous results demonstrated that PAP may be activated in renal microsomes via an NADPH-independent mechanism.
Spec (may) Positive_regulation (activated) of PAP
20) Confidence 0.22 Published 1983 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 6636173 Disease Relevance 0.24 Pain Relevance 0.81

General Comments

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