INT45168

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Context Info
Confidence 0.58
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 10.15
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ASAP1) cytoplasm (ASAP1)
Anatomy Link Frequency
lung 3
ASAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 122 97.94 Very High Very High Very High
Paracetamol 17 95.16 Very High Very High Very High
Kinase C 61 92.64 High High
fibrosis 79 89.88 High High
antagonist 16 85.44 High High
Inflammation 72 77.36 Quite High
Infliximab 3 75.64 Quite High
Serotonin 4 72.96 Quite High
Dopamine 24 65.20 Quite High
Catecholamine 27 64.52 Quite High
Disease Link Frequency Relevance Heat
Pulmonary Alveolar Proteinosis 43 100.00 Very High Very High Very High
Spontaneous Remission 1 100.00 Very High Very High Very High
Cervical Cancer 273 99.22 Very High Very High Very High
Hypertension 168 99.18 Very High Very High Very High
Dyspnea 38 98.50 Very High Very High Very High
Pulmonary Embolism 120 97.94 Very High Very High Very High
Sarcoidosis 219 97.82 Very High Very High Very High
Papillomavirus Infection 1125 96.92 Very High Very High Very High
Recurrence 35 94.56 High High
Sepsis 23 94.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our quantitative and qualitative findings suggest that being unmarried or living alone, living in an isolated place, and being older tend to decrease Pap test use.
Negative_regulation (decrease) of Pap
1) Confidence 0.58 Published 2007 Journal Prev Chronic Dis Section Body Doc Link PMC2099293 Disease Relevance 0.22 Pain Relevance 0
In this complementary study, we examined data from the National Health Interview Survey focusing on the correlates of screening for women aged 55 years or older, an age group in which invasive cervical cancer rates escalate and rates of obtaining Pap tests decline.
Negative_regulation (decline) of Pap associated with cervical cancer
2) Confidence 0.37 Published 2007 Journal Prev Chronic Dis Section Abstract Doc Link PMC2099293 Disease Relevance 0.41 Pain Relevance 0
Nevertheless, the radically different binding profiles observed in the presence and absence of PAP are consistent with the structure-based mechanisms proposed above.
Negative_regulation (absence) of PAP
3) Confidence 0.35 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0 Pain Relevance 0
Interestingly, binding of SULT1C1, 1B1, and 1E1 to resveratrol was only observed in the absence of PAP, but all are active toward this substrate.
Negative_regulation (absence) of PAP
4) Confidence 0.35 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0 Pain Relevance 0.03
Finally, Figure 8F shows that the clustering of hSULTs again differs when considering the binding of compounds in the absence of PAP.
Negative_regulation (absence) of PAP
5) Confidence 0.35 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0 Pain Relevance 0.12
Estimation of relevant degrees of RVED or PAP reduction can possibly be derived indirectly from human thrombolysis studies, since thrombolytic treatment was associated with reduced mortality (4.7% vs 11.1%) in the setting of right ventricular dilatation in acute pulmonary embolism [21].
Negative_regulation (reduction) of PAP associated with pulmonary embolism and cva
6) Confidence 0.33 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2859373 Disease Relevance 0.41 Pain Relevance 0.17
Thirdly, it is possible that the dose of epoprostenol was not sufficient to decrease PAP.
Negative_regulation (decrease) of PAP
7) Confidence 0.33 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2859373 Disease Relevance 0.58 Pain Relevance 0.03
In animal models of acute pulmonary embolism, treatment with different vasodilators, including prostacyclin, was associated with a more pronounced decrease in mean PAP of 12-33% [14,25-27].
Negative_regulation (decrease) of PAP associated with pulmonary embolism and cva
8) Confidence 0.29 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2859373 Disease Relevance 0.32 Pain Relevance 0.16
The absence of a decrease in systolic PAP in either treatment group may indicate that patients were already past the phase of acute pulmonary vasocontriction.
Negative_regulation (decrease) of PAP
9) Confidence 0.29 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2859373 Disease Relevance 0.38 Pain Relevance 0.23
Addition of glutathione, bis(p-nitrophenyl)phosphate (a deacetylase inhibitor), or PAP inhibited this covalent binding.
Negative_regulation (inhibitor) of PAP
10) Confidence 0.19 Published 1983 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 6636173 Disease Relevance 0.18 Pain Relevance 0.93
Nevertheless, the link between GM-CSF, impaired y+LAT1 expression and surfactant accumulation in LPI remains to be elucidated, and our report is not conclusive, taking into consideration the single case and the possibility, although rare, of a spontaneous remission of PAP.
Negative_regulation (remission) of PAP associated with pulmonary alveolar proteinosis and spontaneous remission
11) Confidence 0.18 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0.57 Pain Relevance 0
Propranolol is known to be an inhibitor of the enzyme phosphatidic acid phosphohydrolase (PAP), which catalyses the conversion of PA to DAG [29].
Negative_regulation (inhibitor) of PAP
12) Confidence 0.17 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0.28
The decrease in PAP is consistent with recent findings of Maybauer and colleagues, reporting that rhAPC, administered 1 hour subsequent to smoke inhalation and sepsis, improves pulmonary function in sheep [20].
Negative_regulation (decrease) of PAP associated with sepsis
13) Confidence 0.16 Published 2008 Journal Crit Care Section Body Doc Link PMC2575593 Disease Relevance 0.59 Pain Relevance 0.04
CONCLUSION: Bupivacaine and ropivacaine attenuated N-formyl-L-leucine-methionyl-L-phenylalanine-induced PAP, reduced lung edema, and diminished ET-1 release.
Negative_regulation (attenuated) of PAP in lung
14) Confidence 0.12 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19690261 Disease Relevance 0 Pain Relevance 0
Lidocaine and mepivacaine are more effective in reducing PAP and edema formation, but long-acting local anesthetics also inhibit ET-1 depletion and therefore have increased anti-inflammatory properties.


Negative_regulation (reducing) of PAP
15) Confidence 0.12 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19690261 Disease Relevance 0 Pain Relevance 0
After both doses of inhaled NO, but particularly 10 ppm, PAP was reduced (P < 0.05) and lung compliance increased (P < 0.05) from the ??
Negative_regulation (reduced) of PAP in lung
16) Confidence 0.12 Published 1997 Journal Crit Care Section Abstract Doc Link PMC28996 Disease Relevance 0.15 Pain Relevance 0
After inhaled NO 5 ppm, PAP was significantly reduced (P < 0.05) from ??
Negative_regulation (reduced) of PAP
17) Confidence 0.12 Published 1997 Journal Crit Care Section Body Doc Link PMC28996 Disease Relevance 0 Pain Relevance 0
and CD36 deficiency in PAP was cell type-specific in the lung (i.e. found in AM and not in bronchial epithelial cells).
Negative_regulation (deficiency) of PAP in lung associated with pulmonary alveolar proteinosis
18) Confidence 0.07 Published 2005 Journal Respir Res Section Body Doc Link PMC1242255 Disease Relevance 0.95 Pain Relevance 0.06
Data from our centre on a small cohort of sarcoid patients with persistent dyspnoea and elevated PAP indicative of PH have shown that treatment with bosentan reduces PAP [31] (Table 2).
Negative_regulation (reduces) of PAP associated with sarcoidosis, hypertension and dyspnea
19) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2072890 Disease Relevance 1.20 Pain Relevance 0.19
However, within 6 months of additional therapy with bosentan, there was a marked reduction in PAP and an even greater reduction in PVR.
Negative_regulation (reduction) of PAP
20) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2072890 Disease Relevance 0.98 Pain Relevance 0.10

General Comments

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