INT45176

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Context Info
Confidence 0.59
First Reported 1981
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 34
Total Number 35
Disease Relevance 22.22
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LPL) small molecule metabolic process (LPL) extracellular region (LPL)
plasma membrane (LPL) lipid metabolic process (LPL)
Anatomy Link Frequency
plasma 9
muscle 2
skeletal muscle 2
adipose tissue 2
tubes 1
LPL (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 12 99.58 Very High Very High Very High
abdominal pain 18 97.76 Very High Very High Very High
diclofenac 3 95.80 Very High Very High Very High
Inflammatory marker 3 89.20 High High
agonist 52 85.92 High High
Inflammation 81 81.60 Quite High
alcohol 19 79.28 Quite High
Catecholamine 10 75.12 Quite High
cINOD 4 75.00 Quite High
Endocannabinoid 37 50.00 Quite Low
Disease Link Frequency Relevance Heat
Obesity 574 100.00 Very High Very High Very High
Hyperlipidemia 118 99.90 Very High Very High Very High
Disorder Of Lipid Metabolism 430 99.80 Very High Very High Very High
Xanthomatosis 5 99.76 Very High Very High Very High
Impaired Glucose Tolerance 14 99.36 Very High Very High Very High
Pancreatitis 33 99.12 Very High Very High Very High
Polycystic Ovary Syndrome 85 98.64 Very High Very High Very High
Hyperglycemia 12 98.60 Very High Very High Very High
Stress 50 97.92 Very High Very High Very High
Hyperinsulinism 24 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite an absolute deficiency of LPL mass and activity demonstrated by analysis of patient post-heparin plasma, in vitro expression of both LPL mutants was normal, suggesting that the absence of LPL in patient post-heparin plasma was a result of altered in vivo processing.
Negative_regulation (deficiency) of LPL in plasma
1) Confidence 0.59 Published 1996 Journal J. Lipid Res. Section Abstract Doc Link 8728326 Disease Relevance 0.17 Pain Relevance 0.06
Initial diagnosis of lipoprotein lipase deficiency in a 75-year-old man.
Negative_regulation (deficiency) of lipoprotein lipase associated with pain
2) Confidence 0.57 Published 1983 Journal Am. J. Med. Section Title Doc Link 6638056 Disease Relevance 0.59 Pain Relevance 0.20
Correction of feline lipoprotein lipase deficiency with adeno-associated virus serotype 1-mediated gene transfer of the lipoprotein lipase S447X beneficial mutation.
Negative_regulation (deficiency) of lipoprotein lipase
3) Confidence 0.57 Published 2006 Journal Hum. Gene Ther. Section Title Doc Link 16716106 Disease Relevance 0.32 Pain Relevance 0.09
As a prelude to gene therapy for human LPL deficiency, we tested the efficacy of AAV1-LPL(S447X) in LPL(/) cats, which demonstrate hypertriglyceridemia (plasma TGs, >10,000 mg/dl) and clinical symptoms similar to LPL deficiency in humans, including pancreatitis.
Negative_regulation (deficiency) of LPL in plasma associated with pancreatitis and hyperlipidemia
4) Confidence 0.57 Published 2006 Journal Hum. Gene Ther. Section Abstract Doc Link 16716106 Disease Relevance 0.37 Pain Relevance 0.09
Conversely, a two-week period of detraining in runners decreased LPL activity in skeletal muscle but increased LPL activity in adipose tissue [28].
Negative_regulation (decreased) of LPL in skeletal muscle associated with obesity
5) Confidence 0.52 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1584255 Disease Relevance 0.46 Pain Relevance 0
Familial lipoprotein lipase (LPL) deficiency is an inherited disorder of lipoprotein metabolism characterized by hypertriglyceridemia and recurrent episodes of abdominal pain and pancreatitis.
Negative_regulation (deficiency) of lipoprotein lipase associated with abdominal pain, pancreatitis and hyperlipidemia
6) Confidence 0.43 Published 1996 Journal J. Lipid Res. Section Abstract Doc Link 8728326 Disease Relevance 0.29 Pain Relevance 0.10
Familial lipoprotein lipase (LPL) deficiency is an inherited disorder of lipoprotein metabolism characterized by hypertriglyceridemia and recurrent episodes of abdominal pain and pancreatitis.
Negative_regulation (deficiency) of LPL associated with abdominal pain, pancreatitis and hyperlipidemia
7) Confidence 0.43 Published 1996 Journal J. Lipid Res. Section Abstract Doc Link 8728326 Disease Relevance 0.29 Pain Relevance 0.10
We have studied the genetic basis of LPL deficiency in a 62-year-old black male with undetectable pre- and post-heparin plasma LPL mass and activity, DNA sequence analysis of the patient's LPL cDNA and gene as well as digestion with Bcl I and Asu I revealed that the proband is a homozygote for two separate gene defects.
Negative_regulation (deficiency) of LPL in plasma
8) Confidence 0.43 Published 1996 Journal J. Lipid Res. Section Abstract Doc Link 8728326 Disease Relevance 0.29 Pain Relevance 0.10
Preclinical studies evaluating alipogene tiparvovec in a mouse model of LPL deficiency demonstrated a long-term, dose-dependent correction of the lipid abnormalities.
Negative_regulation (deficiency) of LPL associated with congenital anomalies
9) Confidence 0.43 Published 2009 Journal Curr. Opin. Mol. Ther. Section Abstract Doc Link 20072945 Disease Relevance 0.59 Pain Relevance 0.08
The lack of functional LPL in patients with LPL deficiency causes an accumulation of triglyceride (TG)-rich lipoproteins in the plasma.
Negative_regulation (deficiency) of LPL in plasma
10) Confidence 0.43 Published 2009 Journal Curr. Opin. Mol. Ther. Section Abstract Doc Link 20072945 Disease Relevance 0.54 Pain Relevance 0.10
Familial LPL deficiency is a rare, autosomal-recessive disorder of lipoprotein metabolism that is characterized by severe hypertriglyceridemia with episodes of abdominal pain, acute pancreatitis and eruptive cutaneous xanthomatosis.
Negative_regulation (deficiency) of LPL associated with xanthomatosis, abdominal pain, pancreatitis and hyperlipidemia
11) Confidence 0.43 Published 2009 Journal Curr. Opin. Mol. Ther. Section Abstract Doc Link 20072945 Disease Relevance 0.44 Pain Relevance 0.09
Homozygosity for two point mutations in the lipoprotein lipase (LPL) gene in a patient with familial LPL deficiency: LPL(Asp9-->Asn, Tyr262-->His).
Negative_regulation (deficiency) of LPL
12) Confidence 0.43 Published 1996 Journal J. Lipid Res. Section Title Doc Link 8728326 Disease Relevance 0.28 Pain Relevance 0.09
The de novo diagnosis of lipoprotein lipase deficiency in a 75-year-old man illustrates important points about this disease.
Negative_regulation (deficiency) of lipoprotein lipase associated with disease
13) Confidence 0.42 Published 1983 Journal Am. J. Med. Section Abstract Doc Link 6638056 Disease Relevance 0.60 Pain Relevance 0.11
Lipoprotein lipase deficiency, characterized by recurrent pancreatitis, profound hypertriglyceridemia, and delayed clearance of chylomicrons, is generally first diagnosed in childhood.
Negative_regulation (deficiency) of Lipoprotein lipase associated with pancreatitis, hyperlipidemia and disorder of lipid metabolism
14) Confidence 0.42 Published 1983 Journal Am. J. Med. Section Abstract Doc Link 6638056 Disease Relevance 0.44 Pain Relevance 0
Two rare genetic causes of severe HTG are LPL deficiency and apolipoprotein (apo) C-II deficiency lead to TG elevations that are astonishingly high.
Negative_regulation (deficiency) of LPL associated with hyperlipidemia and disorder of lipid metabolism
15) Confidence 0.42 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1963453 Disease Relevance 1.16 Pain Relevance 0.06
As a prelude to gene therapy for human LPL deficiency, we tested the efficacy of AAV1-LPL(S447X) in LPL(/) cats, which demonstrate hypertriglyceridemia (plasma TGs, >10,000 mg/dl) and clinical symptoms similar to LPL deficiency in humans, including pancreatitis.
Negative_regulation (deficiency) of LPL in plasma associated with pancreatitis and hyperlipidemia
16) Confidence 0.41 Published 2006 Journal Hum. Gene Ther. Section Abstract Doc Link 16716106 Disease Relevance 0.36 Pain Relevance 0.08
Since both indomethacin and diclofenac sodium are potent inhibitors of prostaglandin synthetase, these findings are consistent with the hypothesis tht prostaglandins are involved in the feed-back regulation of lipolysis, and mediate the inhibitory effect of lipolysis on lipoprotein lipase activity.
Negative_regulation (effect) of lipoprotein lipase associated with diclofenac
17) Confidence 0.38 Published 1981 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 6796423 Disease Relevance 0.07 Pain Relevance 0.21
The lack of functional LPL in patients with LPL deficiency causes an accumulation of triglyceride (TG)-rich lipoproteins in the plasma.
Negative_regulation (lack) of LPL in plasma
18) Confidence 0.37 Published 2009 Journal Curr. Opin. Mol. Ther. Section Abstract Doc Link 20072945 Disease Relevance 0.54 Pain Relevance 0.10
At the time of publication, a phase II/III trial in patients with LPL deficiency, being conducted to further support the submission of an MAA to the EMEA for alipogene tiparvovec, was ongoing.
Negative_regulation (deficiency) of LPL
19) Confidence 0.37 Published 2009 Journal Curr. Opin. Mol. Ther. Section Abstract Doc Link 20072945 Disease Relevance 0.50 Pain Relevance 0.06
Indeed, it was shown, in vivo, that Ala12 allele is associated with a reduced LPL activity in postheparin plasma [93]; higher leptin levels were observed in Pro12Ala compared to Pro12Pro carrier women [92].
Negative_regulation (reduced) of LPL in plasma
20) Confidence 0.35 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 1.28 Pain Relevance 0

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