INT45199

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Context Info
Confidence 0.86
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.31
Pain Relevance 3.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cndp2) peptidase activity (Cndp2) cytoplasm (Cndp2)
Anatomy Link Frequency
spinal cord 1
KTP 1
tail 1
cleavage 1
Cndp2 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 2 100.00 Very High Very High Very High
Enkephalin 7 99.72 Very High Very High Very High
tail-flick 14 99.44 Very High Very High Very High
Spinal cord 6 99.44 Very High Very High Very High
Morphine 16 99.26 Very High Very High Very High
Neuropeptide 12 99.04 Very High Very High Very High
antinociception 27 97.92 Very High Very High Very High
Analgesic 44 97.12 Very High Very High Very High
analgesia 28 96.64 Very High Very High Very High
Potency 4 94.00 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 2 89.24 High High
Injury 2 84.72 Quite High
Nociception 5 71.84 Quite High
Pressure And Volume Under Development 1 66.12 Quite High
Toxicity 2 30.32 Quite Low
Pain 14 5.00 Very Low Very Low Very Low
Syndrome 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Neuropathic Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(nearly comparable to morphine) administration are probably due to peptidase degradation.
Protein_catabolism (degradation) of peptidase associated with morphine
1) Confidence 0.86 Published 1983 Journal Farmaco Sci Section Abstract Doc Link 6641930 Disease Relevance 0 Pain Relevance 0.53
As endopeptidase played a major role in Substance P degradation in the mouse spinal cord, Bestatin potentiated the antinociception having only a mild effect (Sakurada et al., 2004).
Protein_catabolism (degradation) of peptidase in spinal cord associated with antinociception, spinal cord and substance p
2) Confidence 0.64 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.31 Pain Relevance 1.06
The release of the TRH analogue in the brain is orchestrated by a sequential metabolism utilizing esterase/lipase, peptidyl glycine alpha-amidating monooxygenase (PAM), peptidase cleavage, and glutaminyl cyclase.
Protein_catabolism (cleavage) of peptidase in cleavage
3) Confidence 0.19 Published 1999 Journal J. Med. Chem. Section Abstract Doc Link 10579819 Disease Relevance 0 Pain Relevance 0.12
The present study found that endomorphin-2 was degraded approximately twice as fast than the chromogenic substrate, Ala-Pro-2naphthylamide, by dipeptidyl peptidase IV, whereas d-Pro2-endomorphin-2 was totally resistant to this enzyme's action. d-Pro2-endomorphin-2 (ED50=0.05 microg) was more potent than endomorphin-2 (ED50=30 microg) in significantly increasing tail-flick latencies with longer durations of action.
Protein_catabolism (degraded) of peptidase in tail associated with tail-flick
4) Confidence 0.10 Published 1999 Journal Brain Res. Section Abstract Doc Link 9878785 Disease Relevance 0 Pain Relevance 0.58
Astrocytes also degraded L-KTP through a low affinity peptidase (K(m) approximately 2 mM).
Protein_catabolism (degraded) of peptidase in KTP
5) Confidence 0.07 Published 2010 Journal Brain Res. Section Abstract Doc Link 20537989 Disease Relevance 0 Pain Relevance 0.12
Neuropeptide inactivation is generally thought to occur via peptidase-mediated degradation.
Protein_catabolism (degradation) of peptidase associated with neuropeptide
6) Confidence 0.05 Published 2010 Journal Brain Res. Section Abstract Doc Link 20537989 Disease Relevance 0 Pain Relevance 0.15
Resistance of FK 33-824 and other enkephalin analogues to peptidase degradation.
Protein_catabolism (degradation) of peptidase associated with enkephalin
7) Confidence 0.02 Published 1980 Journal Brain Res. Bull. Section Title Doc Link 6988046 Disease Relevance 0 Pain Relevance 0.60

General Comments

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