INT45201

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Context Info
Confidence 0.42
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 4.02
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCA4) ATPase activity (ABCA4) plasma membrane (ABCA4)
transmembrane transport (ABCA4)
Anatomy Link Frequency
fat 3
body 2
muscle fibers 1
ABCA4 (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 1 87.64 High High
Pain 122 74.64 Quite High
Inflammation 84 67.84 Quite High
Mcgill questionnaire 10 35.20 Quite Low
Inflammatory mediators 18 34.40 Quite Low
Fibrositis 14 22.60 Low Low
corticosteroid 3 19.72 Low Low
Lasting pain 8 7.28 Low Low
cytokine 11 5.00 Very Low Very Low Very Low
Hyperalgesia 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 7 99.04 Very High Very High Very High
Pulmonary Disease 95 98.14 Very High Very High Very High
Obesity 191 94.96 High High
Lymphedema 10 92.20 High High
Stress 21 86.68 High High
Metabolic Syndrome 13 84.96 Quite High
Adrenocortical Hyperfunction 1 76.92 Quite High
Adiposis Dolorosa 56 76.48 Quite High
Pain 140 74.64 Quite High
Disease 17 73.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Muscle denervation or blockade of axoplasmic flow by colchicine with no impairment of neuro-muscular transmission, cause a decrease of RMP of muscle fibers, and a pH change from 7.2 to 8.2 induces a hyperpolarization of the muscle membrane under these conditions.
Negative_regulation (decrease) of RMP in muscle fibers
1) Confidence 0.42 Published 1983 Journal Fiziol Zh SSSR Im I M Sechenova Section Abstract Doc Link 6641996 Disease Relevance 0 Pain Relevance 0.09
The loss in FFM was confirmed by a Wilcoxon rank-sign test (p = 0.008).
Negative_regulation (loss) of FFM
2) Confidence 0.27 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1584255 Disease Relevance 0 Pain Relevance 0
In healthy primates, ten to 11 years of caloric restriction lowers resting EE, beyond the decrease attributed to losses in FFM and fat mass [34,35].
Negative_regulation (losses) of FFM in fat
3) Confidence 0.17 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.40 Pain Relevance 0
In humans we now show that short-term caloric restriction with or without exercise reduces fat mass, FFM, and absolute 24-h EE.
Negative_regulation (reduces) of FFM in fat
4) Confidence 0.12 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.29 Pain Relevance 0
Nevertheless, cachectic patients with COPD experiencing reductions in their body weight below the physiological range suffer from both loss of FFM in association with the loss of FM [50].
Negative_regulation (loss) of FFM in body associated with body weight and pulmonary disease
5) Confidence 0.07 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 2.53 Pain Relevance 0.06
Although there was a nonsignificant increase in percent fat (32.4 ± 3.4% to 35.4 ± 3.7%) and total fat mass (27.2 ± 3.9 to 32.9 ± 6.2 kg), there was a trend to decrease FFM (55 ± 3.8 vs 54.9 ± 3.3 kg; P = 0.053) by BIA.
Negative_regulation (decrease) of FFM in fat
6) Confidence 0.02 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004643 Disease Relevance 0.39 Pain Relevance 0.31
In BIA, higher TBW results in a measure of lower body fat percentage; less water increases the percentage of body fat and decreases calculated FFM.
Negative_regulation (decreases) of FFM in body
7) Confidence 0.02 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004643 Disease Relevance 0.40 Pain Relevance 0.05

General Comments

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