INT45208

Context Info Confidence 0.10 First Reported 1983 Last Reported 2008 Negated 1 Speculated 0 Reported most in Body Documents 2 Total Number 5 Disease Relevance 3.79 Pain Relevance 0.58

small molecule metabolic process (NEU1) hydrolase activity, acting on glycosyl bonds (NEU1) cytoplasmic membrane-bounded vesicle (NEU1) plasma membrane (NEU1) lysosome (NEU1)

Anatomy Link Frequency polymorphonuclear leukocytes 1 NEU1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 92 97.48 cytokine 48 96.96 cINOD 1 74.28 aspirin 1 71.84 tolerance 8 5.00 Potency 8 5.00 palliative 4 5.00 ketamine 4 5.00

Disease Link Frequency Relevance Heat Acne 328 99.82 Disease 32 99.20 INFLAMMATION 85 97.48 Infection 32 97.20 Adhesions 12 91.56 Hyperlipidemia 4 91.52 Immunization 24 90.28 Necrosis 4 84.76 Cancer 4 84.40 Bacterial Meningitis 4 72.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Possible role of arachidonic acid and of phospholipase A2 in the control of lysosomal enzyme release from human polymorphonuclear leukocytes.

Regulation (control) of lysosomal enzyme in polymorphonuclear leukocytes

1) Confidence 0.10 Published 1983 Journal J Clin Lab Immunol Section Title Doc Link 6644791 Disease Relevance 0.07 Pain Relevance 0.11

No immunoreactivity against sialidase was detectable in GFP-immunized mice (Figure 3B, lane 2).

Neg (No) Regulation (immunoreactivity) of sialidase

2) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 0.15 Pain Relevance 0

These results suggest that a vaccine targeting sialidase effectively suppresses P. acnes-induced production of the pro-inflammatory cytokine MIP-2 in the mice.

Regulation (targeting) of sialidase associated with inflammation and cytokine

3) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 1.07 Pain Relevance 0.44

Here we create an acne vaccine targeting a cell wall-anchored sialidase of P. acnes.

Regulation (targeting) of sialidase associated with acne

4) Confidence 0.09 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2212713 Disease Relevance 0.99 Pain Relevance 0.03

Thus, vaccination targeting sialidase of P. acnes may be an efficient modality for the prevention of early infection of P. acnes.

Regulation (targeting) of sialidase associated with infection

5) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 1.50 Pain Relevance 0

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