INT45208

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Context Info
Confidence 0.10
First Reported 1983
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 3.79
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (NEU1) hydrolase activity, acting on glycosyl bonds (NEU1) cytoplasmic membrane-bounded vesicle (NEU1)
plasma membrane (NEU1) lysosome (NEU1)
Anatomy Link Frequency
polymorphonuclear leukocytes 1
NEU1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 92 97.48 Very High Very High Very High
cytokine 48 96.96 Very High Very High Very High
cINOD 1 74.28 Quite High
aspirin 1 71.84 Quite High
tolerance 8 5.00 Very Low Very Low Very Low
Potency 8 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acne 328 99.82 Very High Very High Very High
Disease 32 99.20 Very High Very High Very High
INFLAMMATION 85 97.48 Very High Very High Very High
Infection 32 97.20 Very High Very High Very High
Adhesions 12 91.56 High High
Hyperlipidemia 4 91.52 High High
Immunization 24 90.28 High High
Necrosis 4 84.76 Quite High
Cancer 4 84.40 Quite High
Bacterial Meningitis 4 72.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Possible role of arachidonic acid and of phospholipase A2 in the control of lysosomal enzyme release from human polymorphonuclear leukocytes.
Regulation (control) of lysosomal enzyme in polymorphonuclear leukocytes
1) Confidence 0.10 Published 1983 Journal J Clin Lab Immunol Section Title Doc Link 6644791 Disease Relevance 0.07 Pain Relevance 0.11
No immunoreactivity against sialidase was detectable in GFP-immunized mice (Figure 3B, lane 2).


Neg (No) Regulation (immunoreactivity) of sialidase
2) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 0.15 Pain Relevance 0
These results suggest that a vaccine targeting sialidase effectively suppresses P. acnes-induced production of the pro-inflammatory cytokine MIP-2 in the mice.


Regulation (targeting) of sialidase associated with inflammation and cytokine
3) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 1.07 Pain Relevance 0.44
Here we create an acne vaccine targeting a cell wall-anchored sialidase of P. acnes.
Regulation (targeting) of sialidase associated with acne
4) Confidence 0.09 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2212713 Disease Relevance 0.99 Pain Relevance 0.03
Thus, vaccination targeting sialidase of P. acnes may be an efficient modality for the prevention of early infection of P. acnes.
Regulation (targeting) of sialidase associated with infection
5) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 1.50 Pain Relevance 0

General Comments

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