INT4521

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Context Info
Confidence 0.02
First Reported 1975
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.18
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PBOV1) cytoplasm (PBOV1)
PBOV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 2 98.80 Very High Very High Very High
Clonidine 2 75.00 Quite High
anesthesia 2 48.48 Quite Low
gABA 2 5.00 Very Low Very Low Very Low
sodium channel 2 5.00 Very Low Very Low Very Low
interstitial cystitis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bradycardia 1 92.56 High High
Contracture 2 90.88 High High
Carcinoma 62 86.64 High High
Pressure And Volume Under Development 3 85.68 High High
Cancer 56 82.24 Quite High
Diuresis 1 75.00 Quite High
Stress Incontinence 8 57.92 Quite High
Chromosome Aberrations 6 49.92 Quite Low
Aneuploidy 2 43.92 Quite Low
Chromosome Deletion 2 36.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Yet when a supervised analytic approach was used, a small number of differentially expressed genes were identified; these differences were most likely limited to a single pathway--the chloride ion binding activity pathway--which was more frequently activated in rUC than in bUC.


Positive_regulation (activated) of rUC
1) Confidence 0.02 Published 2010 Journal BMC Med Genomics Section Abstract Doc Link PMC3022544 Disease Relevance 0.55 Pain Relevance 0
The exception was an apparent increase in the overall 9p loss in rUC, which is the region containing the cyclin-dependent kinase inhibitor 2A and 2B (CDKN2A and CDKN2B) genes.
Positive_regulation (increase) of rUC
2) Confidence 0.02 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC3022544 Disease Relevance 0.15 Pain Relevance 0
In the second group of animals it was given intravenously at a rate of 12.0 mug/min and resulted in a significant decrease of ERPF, UNaV, UC1V, and increase in FF, UV, and CH2O) but had no effect upon GFR, Cosm, UKV, UCaV and UPO4V.
Positive_regulation (increase) of UC1V
3) Confidence 0.01 Published 1975 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 1187716 Disease Relevance 0.34 Pain Relevance 0.15
Pretreatment with aminoguanidine or dexamethasone, inhibitors of inducible NO synthase (iNOS), prevented the increase in UNOXV and UcGMPV but had no impact on mean arterial pressure (BP), renal vascular resistance (RVR) or GFR.
Positive_regulation (increase) of UcGMPV associated with dexamethasone
4) Confidence 0.01 Published 1997 Journal Kidney Int. Section Abstract Doc Link 9186887 Disease Relevance 0.06 Pain Relevance 0.05
When acutely prepared rats received L-NAME, a non-specific NOS inhibitor, BP and RVR increased but paradoxical increases in UNOXV and UcGMPV were also seen.
Positive_regulation (increases) of UcGMPV
5) Confidence 0.01 Published 1997 Journal Kidney Int. Section Abstract Doc Link 9186887 Disease Relevance 0.09 Pain Relevance 0.04

General Comments

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