INT45226

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Context Info
Confidence 0.31
First Reported 1983
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.78
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
aortas 1
Hd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 20 93.36 High High
anesthesia 7 86.44 High High
Inflammation 30 54.80 Quite High
dexamethasone 70 50.00 Quite Low
Central nervous system 30 23.20 Low Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Neuropeptide 5 5.00 Very Low Very Low Very Low
iatrogenic 5 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
sodium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Failure 108 100.00 Very High Very High Very High
Diabetes Mellitus 92 98.68 Very High Very High Very High
Insulin Resistance 185 94.96 High High
Impaired Glucose Tolerance 20 94.04 High High
Hyperlipidemia 140 88.60 High High
Body Weight 43 85.72 High High
Hyperglycemia 50 79.68 Quite High
Polyuria 15 76.40 Quite High
Cushing's Syndrome /

Hypercortisolism

5 71.68 Quite High
Metabolic Syndrome 135 62.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The water intake remained unaltered in the HF and LD rats when compared to control, but it was increased significantly in the HD, HF-LD and HF-HD rats.
Positive_regulation (increased) of HD
1) Confidence 0.31 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2414485 Disease Relevance 0.25 Pain Relevance 0
Data indicate that the aortic endothelial (EC) HD activity was increased more than 130% in the untreated diabetic group but was similar to control values in the diabetic group receiving alpha-hydrazinohistidine; similarily, the EC histamine content from diabetic aortas increased 127% over control values, but in EC from diabetic animals receiving alpha-hydrazinohistidine it was comparable to control values.
Positive_regulation (increased) of HD in aortas associated with diabetes mellitus
2) Confidence 0.29 Published 1983 Journal Arteriosclerosis Section Abstract Doc Link 6651615 Disease Relevance 1.02 Pain Relevance 0.09
The water intake remained unaltered in the HF and LD rats when compared to control, but it was increased significantly in the HD, HF-LD and HF-HD rats.
Positive_regulation (increased) of HD
3) Confidence 0.20 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2414485 Disease Relevance 0.26 Pain Relevance 0
When compared to HF rats the fasting insulin was increased more significantly in the Dex treated [HD & LD] rats.
Positive_regulation (increased) of HD
4) Confidence 0.20 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2414485 Disease Relevance 0.23 Pain Relevance 0
Fasting glucose was not altered between control and HF rats, but it was increased significantly in the HD and LD rats and the increase was directly proportional the dose of Dex used.
Positive_regulation (increased) of HD
5) Confidence 0.20 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2414485 Disease Relevance 0.22 Pain Relevance 0
The increased level of Dex in the HD and LD rats might have altered the membrane structure and enter the cell by concentration gradient which in turn have caused insulin resistance and impaired glucose tolerance in the HD and LD rats [Fig. 1 & Table 2] [70,71,73,74].
Positive_regulation (increased) of HD associated with tolerance, insulin resistance and impaired glucose tolerance
6) Confidence 0.20 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2414485 Disease Relevance 0.85 Pain Relevance 0.05
60% more likely to be employed than HD patients; however, in a two-stage model accounting for endogeneity, the relative increase in the probability of working for PD patients compared to HD patients was only 14.7%.
Positive_regulation (increase) of HD associated with renal failure
7) Confidence 0.11 Published 2008 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2441769 Disease Relevance 0.77 Pain Relevance 0
However, some of the genes that changed in PM-HD were the same as those affected by zinc (Figure 6), suggesting that those genes are changed as a result of exposure to zinc.
Positive_regulation (changed) of PM-HD
8) Confidence 0.06 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199289 Disease Relevance 0.11 Pain Relevance 0.03

General Comments

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