INT45230

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 1983
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 20
Total Number 22
Disease Relevance 9.30
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD79A)
Anatomy Link Frequency
nasal 2
juvenile 1
lung 1
bowel 1
saliva 1
CD79A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 76 100.00 Very High Very High Very High
spinal inflammation 2 97.84 Very High Very High Very High
rheumatoid arthritis 48 97.28 Very High Very High Very High
Arthritis 77 96.76 Very High Very High Very High
cytokine 102 82.96 Quite High
headache 27 77.72 Quite High
Pain 17 74.96 Quite High
depression 10 69.36 Quite High
Antihistamine 3 61.92 Quite High
Inflammatory marker 1 61.32 Quite High
Disease Link Frequency Relevance Heat
Rhinitis 6 100.00 Very High Very High Very High
Lymphatic System Cancer 16 98.52 Very High Very High Very High
Immunization 232 98.36 Very High Very High Very High
Autoimmune Disease 22 98.20 Very High Very High Very High
Low Back Pain 2 97.84 Very High Very High Very High
Rheumatoid Arthritis 48 97.64 Very High Very High Very High
INFLAMMATION 74 96.96 Very High Very High Very High
Periodontitis 2 96.88 Very High Very High Very High
Influenza Virus Infection 128 96.76 Very High Very High Very High
Seronegative Spondarthritis 2 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Its two major outer membrane proteins are important targets for IgA and other protein A reactive immunoglobulins in the sera of some patients with these diseases.
Regulation (targets) of IgA associated with disease
1) Confidence 0.44 Published 1983 Journal Br. J. Rheumatol. Section Abstract Doc Link 6652395 Disease Relevance 0.44 Pain Relevance 0.26
Based on these results we studied a possible change in the concentration of cystatin S, cystatin C, albumin, IgA, amylase activity, and cystatin activity in a whole and parotid saliva of 20 periodontitis patients as a consequence of periodontal treatment.
Spec (possible) Regulation (change) of IgA in saliva associated with periodontitis
2) Confidence 0.31 Published 1996 Journal J. Periodontol. Section Abstract Doc Link 8708950 Disease Relevance 0.45 Pain Relevance 0.12
BAL IgG and IgA response to injected and inhaled 23-PPV
Regulation (response) of IgA
3) Confidence 0.20 Published 2008 Journal Vaccine Section Body Doc Link PMC2612086 Disease Relevance 0 Pain Relevance 0
The concentrations of the serum immunoglobulins, IgG, IgA, and IgM, were previously determined in 200 patients with juvenile rheumatoid arthritis, which showed abnormality in the distribution of these immunoglobulins in JIA10).
Regulation (concentrations) of IgA in juvenile associated with rheumatoid arthritis
4) Confidence 0.15 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3012272 Disease Relevance 1.80 Pain Relevance 0.34
Changes in IgA levels were seen less frequently.
Regulation (Changes) of IgA
5) Confidence 0.13 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC3004381 Disease Relevance 0 Pain Relevance 0
The study results showed a significant increase in immune functions, especially higher numbers of plasma cells and IgA and IgM values in small bowel mucosa of patients in whom bacterial translocation has been positive.


Regulation (values) of IgA in bowel
6) Confidence 0.10 Published 2005 Journal BMC Nurs Section Body Doc Link PMC549542 Disease Relevance 0.25 Pain Relevance 0.08
No change in serum IgG, IgA, or IgM levels was reported in both NHL and autoimmune disease studies.
Neg (No) Regulation (change) of IgA associated with autoimmune disease and lymphatic system cancer
7) Confidence 0.07 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376077 Disease Relevance 1.23 Pain Relevance 0.14
The majority of the responders in each group had an IgG response (22 subjects overall, 61%), as measured by ELISA, but few subjects (4 subjects overall, 11%) had an IgA response, as measured by ELISPOT.
Regulation (response) of IgA
8) Confidence 0.07 Published 2007 Journal Vaccine Section Body Doc Link PMC2652036 Disease Relevance 0 Pain Relevance 0
For subjects receiving 108 CFU: After first immunization mean peak IgG titer to LT 2625 (peak fold increase 2.5), mean peak IgA ASC response to LT 0, mean peak IgG titer to LPS 2073 (15.4), mean peak IgA ASC response to LPS 121.
Regulation (response) of IgA associated with immunization
9) Confidence 0.07 Published 2007 Journal Vaccine Section Body Doc Link PMC2652036 Disease Relevance 0.34 Pain Relevance 0
For subjects receiving 109 CFU: After first immunization mean peak IgG titer to LT 4184 (peak fold increase 4.2), mean peak IgA ASC response to LT 8.29, mean peak IgG titer to LPS 3724 (13.1), mean peak IgA ASC response to LPS 158.
Regulation (response) of IgA associated with immunization
10) Confidence 0.07 Published 2007 Journal Vaccine Section Body Doc Link PMC2652036 Disease Relevance 0.36 Pain Relevance 0
After second immunization mean peak IgG titer to LT 3056 (peak fold increase 3.5), mean peak IgA ASC response to LT 0.73, mean peak IgG titer to LPS 1680 (7.9), mean peak IgA ASC response to LPS 13.
Regulation (response) of IgA associated with immunization
11) Confidence 0.07 Published 2007 Journal Vaccine Section Body Doc Link PMC2652036 Disease Relevance 0.38 Pain Relevance 0
Shortcomings of these studies include inadequate stratification baseline severity based on IGA and inadequate data on pregnancies in 1 study.30

Active-comparator trials

Regulation (based) of IGA
12) Confidence 0.04 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971705 Disease Relevance 0.61 Pain Relevance 0.10
A positive serum IgG response was defined as a 70% increase (fold change of 1.7) as compared to the corresponding baseline sample, whereas a positive serum IgA response was defined as a 50% increase (fold change of 1.5) as compared to baseline.
Regulation (response) of IgA
13) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909895 Disease Relevance 0 Pain Relevance 0
When separating vegan patients into clinical responders and non-responders at 12 months, the effects on oxLDL and anti-PC IgA were seen only in responders (p < 0.05).


Regulation (effects) of IgA
14) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2453753 Disease Relevance 0.35 Pain Relevance 0.06
The presence of a dominant HA-specific IgA response in the upper respiratory tract and a dominant HA-specific IgG response in the lower lung of vaccinated macaques is consistent with the pattern of mucosal antibody induced following influenza infections in mice [44], [45].
Regulation (response) of IgA in lung associated with influenza virus infection and infection
15) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882341 Disease Relevance 0.58 Pain Relevance 0
Mucosal IgA and IgG responses in the bronchioalveolar lavage fluid (BALF) and nasal and tracheal secretions were analyzed by ELISA using recombinant influenza A/New Caledonia/20/99 HA protein as the capture antigen.
Spec (analyzed) Regulation (responses) of IgA in nasal associated with influenza virus infection
16) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882341 Disease Relevance 0.42 Pain Relevance 0
The results of this study indicate that a 1-hr exposure to odorous swine air in an environmental chamber (at levels that could occur downwind from a swine facility both within and beyond the property line) has no significant acute effects on vital signs, lung function, nasal inflammation, salivary IgA, mood, attention, or memory in healthy volunteers.
Neg (no) Regulation (effects) of IgA in nasal associated with rhinitis and inflammation
17) Confidence 0.02 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257549 Disease Relevance 0.24 Pain Relevance 0.12
In human, nasal mucosa can serve as an efficient site for the induction of specific IgA and IgG responses in vaginal secretions [34,35].
Regulation (responses) of IgA in nasal mucosa
18) Confidence 0.02 Published 2007 Journal BMC Vet Res Section Body Doc Link PMC2222256 Disease Relevance 0.34 Pain Relevance 0
It could be a consequence of the induction of specific IgA and IgG responses in vaginal secretions.
Regulation (responses) of IgA
19) Confidence 0.02 Published 2007 Journal BMC Vet Res Section Body Doc Link PMC2222256 Disease Relevance 0.33 Pain Relevance 0.05
Ghose and colleagues (2007) found that transcutaneous immunization with formalin-treated C. difficile toxin A resulted in anti-C. difficile toxin A IgG and IgA responses in serum and anti-C. difficile toxin A IgA in stool in mice (Ghose et al 2007).
Regulation (responses) of IgA associated with immunization
20) Confidence 0.02 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621401 Disease Relevance 0.45 Pain Relevance 0.15

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox