INT45233

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Context Info
Confidence 0.07
First Reported 1983
Last Reported 1983
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Sdcbp) cytoplasm (Sdcbp)
Anatomy Link Frequency
hepatocytes 2
liver 2
Sdcbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 20 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Overdose 2 5.00 Very Low Very Low Very Low
Hepatotoxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In isolated mouse liver cells paracetamol does not require preliminary cytochrome P-450 induction to stimulate MDA formation, even at concentrations ineffective in rat cells.
Positive_regulation (stimulate) of MDA Binding (formation) of in liver associated with paracetamol
1) Confidence 0.07 Published 1983 Journal Chem. Biol. Interact. Section Abstract Doc Link 6652811 Disease Relevance 0 Pain Relevance 0.65
However, 5 mM paracetamol, despite a great depletion of cellular GSH content, does not promote MDA formation either in the rat or in the mouse hepatocytes.
Neg (not) Positive_regulation (promote) of MDA Neg (not) Binding (formation) of in hepatocytes associated with paracetamol
2) Confidence 0.05 Published 1983 Journal Chem. Biol. Interact. Section Abstract Doc Link 6652811 Disease Relevance 0 Pain Relevance 0.71

General Comments

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