INT45234

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Context Info
Confidence 0.37
First Reported 1983
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 20
Total Number 21
Disease Relevance 9.80
Pain Relevance 8.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ldha) mitochondrion (Ldha) oxidoreductase activity (Ldha)
cytoplasm (Ldha)
Anatomy Link Frequency
liver 2
hepatocytes 1
lymphocytes 1
fibroblasts 1
fibrocartilage 1
Ldha (Rattus norvegicus)
Pain Link Frequency Relevance Heat
headache 1 100.00 Very High Very High Very High
Paracetamol 267 99.62 Very High Very High Very High
tolerance 3 93.80 High High
adenocard 6 93.76 High High
Analgesic 6 91.96 High High
depression 19 89.88 High High
fibrosis 32 84.80 Quite High
addiction 5 81.68 Quite High
opiate 4 81.24 Quite High
agonist 15 79.92 Quite High
Disease Link Frequency Relevance Heat
Fever 3 100.00 Very High Very High Very High
Thrombocytopenia 1 100.00 Very High Very High Very High
Fatigue 1 100.00 Very High Very High Very High
Chills 1 100.00 Very High Very High Very High
Lymphopenia 1 100.00 Very High Very High Very High
Headache 1 100.00 Very High Very High Very High
Malaria 2 99.88 Very High Very High Very High
Injury 91 99.42 Very High Very High Very High
Babesiosis 8 99.22 Very High Very High Very High
Fibrosis 86 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Leakage of lactate dehydrogenase (LDH) and potassium (K+), and mg water/mg dry weight quantified cell injury.
LDH Binding (Leakage) of associated with injury
1) Confidence 0.37 Published 1998 Journal Drug Chem Toxicol Section Abstract Doc Link 9839156 Disease Relevance 0.35 Pain Relevance 0.54
Leakage of lactate dehydrogenase (LDH) and potassium (K+), and mg water/mg dry weight quantified cell injury.
lactate dehydrogenase Binding (Leakage) of associated with injury
2) Confidence 0.37 Published 1998 Journal Drug Chem Toxicol Section Abstract Doc Link 9839156 Disease Relevance 0.34 Pain Relevance 0.54
Cell injury was quantified by measuring leakage of lactate dehydrogenase (LDH) and potassium (K+).
LDH Binding (leakage) of associated with injury
3) Confidence 0.37 Published 1996 Journal Toxicology Section Abstract Doc Link 8658536 Disease Relevance 0.38 Pain Relevance 0.55
Cell injury was quantified by measuring leakage of lactate dehydrogenase (LDH) and potassium (K+).
lactate dehydrogenase Binding (leakage) of associated with injury
4) Confidence 0.37 Published 1996 Journal Toxicology Section Abstract Doc Link 8658536 Disease Relevance 0.38 Pain Relevance 0.54
Increased alanine aminotransferase (SGOT, AST) and lactate dehydrogenase (LDH), observed only in high-dose males, were associated with findings in liver.
lactate dehydrogenase Binding (associated) of in liver
5) Confidence 0.37 Published 1994 Journal J Appl Toxicol Section Abstract Doc Link 7884149 Disease Relevance 0.61 Pain Relevance 0.37
Increased alanine aminotransferase (SGOT, AST) and lactate dehydrogenase (LDH), observed only in high-dose males, were associated with findings in liver.
LDH Binding (associated) of in liver
6) Confidence 0.37 Published 1994 Journal J Appl Toxicol Section Abstract Doc Link 7884149 Disease Relevance 0.61 Pain Relevance 0.37
Membrane leakage of lactate dehydrogenase (LDH) is evident in paracetamol treated cells undergoing lipid peroxidation, but not when MDA formation is inhibited by high doses of the drug or by addition of anti-oxidants such as alpha-tocopherol and diphenylphenylenediamine (DPPD).
LDH Binding (leakage) of associated with paracetamol
7) Confidence 0.36 Published 1983 Journal Chem. Biol. Interact. Section Abstract Doc Link 6652811 Disease Relevance 0 Pain Relevance 0.77
Membrane leakage of lactate dehydrogenase (LDH) is evident in paracetamol treated cells undergoing lipid peroxidation, but not when MDA formation is inhibited by high doses of the drug or by addition of anti-oxidants such as alpha-tocopherol and diphenylphenylenediamine (DPPD).
lactate dehydrogenase Binding (leakage) of associated with paracetamol
8) Confidence 0.36 Published 1983 Journal Chem. Biol. Interact. Section Abstract Doc Link 6652811 Disease Relevance 0 Pain Relevance 0.77
Cell injury, as quantified by measuring leakage of lactate dehydrogenase (LDH) and potassium (K+), does not become apparent until 240 min, some 120 min after exposure to paracetamol had ended.
lactate dehydrogenase Binding (leakage) of associated with paracetamol and injury
9) Confidence 0.35 Published 1995 Journal Toxicology Section Abstract Doc Link 8560507 Disease Relevance 0.62 Pain Relevance 0.70
Cell injury, as quantified by measuring leakage of lactate dehydrogenase (LDH) and potassium (K+), does not become apparent until 240 min, some 120 min after exposure to paracetamol had ended.
LDH Binding (leakage) of associated with paracetamol and injury
10) Confidence 0.35 Published 1995 Journal Toxicology Section Abstract Doc Link 8560507 Disease Relevance 0.62 Pain Relevance 0.70
Paracetamol was selected as a model toxin, since it is known to be bioactivated by specific cytochrome P-450s presumably to N-acetyl-p-benzoquinoneimine, a reactive metabolite which upon overdosage of paracetamol causes protein and non-protein thiol depletion, lipid peroxidation and cytotoxicity measurable as LDH leakage.
LDH Binding (leakage) of associated with paracetamol
11) Confidence 0.33 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8748682 Disease Relevance 0.14 Pain Relevance 0.79
LDH activity
LDH Binding (activity) of
12) Confidence 0.25 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2518376 Disease Relevance 0 Pain Relevance 0
However, the activities of SDH and LDH were significantly decreased by ?
LDH Binding (activities) of
13) Confidence 0.23 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994374 Disease Relevance 0.07 Pain Relevance 0
Babesiosis presents clinically as a malaria-like illness with fever, chills, headache, fatigue with lymphopenia, atypical lymphocytes, mildly or transiently elevated serum transaminases, thrombocytopenia, and increased lactate dehydrogenase (LDH) levels.
LDH Binding (illness) of in lymphocytes associated with babesiosis, fever, malaria, lymphopenia, chills, headache, fatigue and thrombocytopenia
14) Confidence 0.20 Published 2007 Journal Eur. J. Clin. Microbiol. Infect. Dis. Section Abstract Doc Link 17558489 Disease Relevance 1.77 Pain Relevance 0.10
Lactate dehydrogenase assay
Lactate dehydrogenase Binding (assay) of
15) Confidence 0.17 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2089075 Disease Relevance 0.71 Pain Relevance 0
Mortality was expressed as a percentage of LDH released.


LDH Binding (percentage) of
16) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.09 Pain Relevance 0.17
Thus, the in vivo presence of LDH5 in fibroblasts and fibrocartilage confirms the previous in vitro findings, and suggests that therapeutic intervention to increase tissue vascularization may inhibit the progression of this disease process.
LDH5 Binding (presence) of in fibrocartilage associated with disease
17) Confidence 0.08 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 1.41 Pain Relevance 0.04
Electron-donating substituents (R = -CH3, -OCH3, -SCH3) decreased the cytotoxicity of paracetamol, when measured as leakage of lactate dehydrogenase from freshly isolated rat hepatocytes, almost completely.
lactate dehydrogenase Binding (leakage) of in hepatocytes associated with paracetamol
18) Confidence 0.05 Published 1995 Journal Chem. Biol. Interact. Section Abstract Doc Link 8548862 Disease Relevance 0 Pain Relevance 1.20
The cytosolic fraction was used for determination of LDH, measured spectrophotometrically at 25°C with pyruvate and NADH.
LDH Spec (determination) Binding (determination) of
19) Confidence 0.04 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0 Pain Relevance 0
Thus, the in vivo presence of LDH5 in fibroblasts and fibrocartilage confirms the previous in vitro findings, and suggests that therapeutic intervention to increase tissue vascularization may inhibit the progression of this disease process.
LDH5 Binding (presence) of in fibroblasts associated with disease
20) Confidence 0.03 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 1.41 Pain Relevance 0.04

General Comments

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