INT45236

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Context Info
Confidence 0.62
First Reported 1983
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.67
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Trf) transport (Trf) mitochondrion (Trf)
extracellular space (Trf) extracellular region (Trf) cytoplasmic membrane-bounded vesicle (Trf)
Anatomy Link Frequency
spleen 2
Trf (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 2 96.24 Very High Very High Very High
cytokine 18 93.40 High High
anesthesia 3 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaemia 2 97.50 Very High Very High Very High
Arthralgia 1 96.24 Very High Very High Very High
Cancer 49 95.40 Very High Very High Very High
Iron Overload 4 89.84 High High
Hyperplasia 1 89.60 High High
Hemolysis 1 88.40 High High
Hypochromic Anemia 2 86.32 High High
Erythropoietic Protoporphyria 4 80.08 Quite High
Sunburn 1 70.48 Quite High
Malignant Neoplastic Disease 6 68.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The homozygous Fechm1Pas mutant involved no tissue iron deficiency but showed a clear-cut redistribution of iron stores from peripheral tissues to the spleen, with a concomitant 2- to 3-fold increase in transferrin expression at the mRNA and the protein levels.
Positive_regulation (increase) of Gene_expression (expression) of transferrin in spleen associated with anaemia
1) Confidence 0.62 Published 2007 Journal Blood Section Abstract Doc Link 17003376 Disease Relevance 0.87 Pain Relevance 0.07
The serum concentrations of TFN-?
Positive_regulation (concentrations) of Gene_expression (concentrations) of TFN
2) Confidence 0.49 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1821034 Disease Relevance 0.37 Pain Relevance 0.12
High transferrin saturation and serum ferritin levels were prevalent in homozygotes: only 1 of 38 homozygotes had values for both of these measurements that were within normal limits.
Positive_regulation (prevalent) of Gene_expression (levels) of transferrin
3) Confidence 0.10 Published 1983 Journal Clin Invest Med Section Abstract Doc Link 6652983 Disease Relevance 0.43 Pain Relevance 0.10

General Comments

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