INT45253

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Context Info
Confidence 0.69
First Reported 1981
Last Reported 2011
Negated 0
Speculated 1
Reported most in Abstract
Documents 20
Total Number 21
Disease Relevance 10.22
Pain Relevance 2.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ltf) transport (Ltf) extracellular region (Ltf)
cytoplasm (Ltf)
Anatomy Link Frequency
epithelial cells 2
brain 1
plugs 1
nerve 1
saliva 1
Ltf (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 25 99.32 Very High Very High Very High
Inflammation 50 95.04 Very High Very High Very High
anesthesia 6 90.16 High High
fibrosis 2 85.68 High High
Bile 1 84.16 Quite High
Pain 4 82.88 Quite High
corticosteroid 2 82.24 Quite High
cytokine 18 76.00 Quite High
imagery 114 56.84 Quite High
palliative 1 56.40 Quite High
Disease Link Frequency Relevance Heat
Mycobacterial Infection 145 99.96 Very High Very High Very High
Pancreatitis 30 99.90 Very High Very High Very High
Apoptosis 31 99.68 Very High Very High Very High
Infection 120 98.52 Very High Very High Very High
Cyst 3 97.48 Very High Very High Very High
Calcification 1 97.36 Very High Very High Very High
Syndrome 9 95.92 Very High Very High Very High
Disease 24 95.12 Very High Very High Very High
Granuloma 5 95.08 Very High Very High Very High
INFLAMMATION 54 95.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant gradual increase in the lactoferrin concentration and output was observed in chronic pancreatitis (mean +/- SE = 1.13 +/- 0.04 microgram/ml, 1.61 +/- 0.44 microgram/min for five controls; 4.73 +/- 0.70 microgram/ml, 14.1 +/- 2.86 micrograms/min for 15 patients with noncalcified mild chronic pancreatitis; 23.6 +/- 4.7 micrograms/ml, 28.4 +/- 13.4 micrograms/min for four with chronic pancreatitis with visible protein plugs or calculi).
Positive_regulation (increase) of lactoferrin in plugs associated with chronic pancreatitis and calculi
1) Confidence 0.69 Published 1983 Journal Am. J. Gastroenterol. Section Abstract Doc Link 6837546 Disease Relevance 0.64 Pain Relevance 0.51
The diagnosis of non-calcifying chronic pancreatitis was suggested by scintigraphic and ultrasonographic investigations and confirmed by the marked increase in lactoferrin levels and the lactoferrin/lipase ratio (greater 0.1 p. cent) in pancreatic juice.
Positive_regulation (increase) of lactoferrin associated with chronic pancreatitis
2) Confidence 0.69 Published 1982 Journal Ann Med Interne (Paris) Section Abstract Doc Link 6810739 Disease Relevance 0.53 Pain Relevance 0.14
The bypass procedure resulted in a rise of both lactoferrin and C3a levels, with lactoferrin reaching 1,092 +/- 69 ng/ml and C3a increasing to 1,884 +/- 179 ng/ml after bypass (p < 0.001 for both).
Positive_regulation (increasing) of lactoferrin
3) Confidence 0.49 Published 1994 Journal ASAIO J. Section Abstract Doc Link 8186493 Disease Relevance 0 Pain Relevance 0.08
The bypass procedure resulted in a rise of both lactoferrin and C3a levels, with lactoferrin reaching 1,092 +/- 69 ng/ml and C3a increasing to 1,884 +/- 179 ng/ml after bypass (p < 0.001 for both).
Positive_regulation (rise) of lactoferrin
4) Confidence 0.49 Published 1994 Journal ASAIO J. Section Abstract Doc Link 8186493 Disease Relevance 0 Pain Relevance 0.08
Elevated fecal lactoferrin was 100% specific in ruling out IBS.
Positive_regulation (Elevated) of lactoferrin
5) Confidence 0.46 Published 2003 Journal Am. J. Gastroenterol. Section Body Doc Link 12818275 Disease Relevance 0.19 Pain Relevance 0
The diagnosis of non-calcifying chronic pancreatitis was suggested by scintigraphic and ultrasonographic investigations and confirmed by the marked increase in lactoferrin levels and the lactoferrin/lipase ratio (greater 0.1 p. cent) in pancreatic juice.
Positive_regulation (increase) of lactoferrin associated with chronic pancreatitis
6) Confidence 0.46 Published 1982 Journal Ann Med Interne (Paris) Section Abstract Doc Link 6810739 Disease Relevance 0.53 Pain Relevance 0.14
A major rise in lactoferrin occurred in the pre bypass period, from 99 +/- 13 (mean +/- SEM) to 647 +/- 48 ng/ml (p < 0.001).
Positive_regulation (rise) of lactoferrin
7) Confidence 0.45 Published 1994 Journal ASAIO J. Section Abstract Doc Link 8186493 Disease Relevance 0 Pain Relevance 0.09
The relationship between neutrophil activation and complement activation during open heart surgery was evaluated by measuring plasma lactoferrin and C3a des Arg (C3a) in 30 adult patients undergoing coronary artery surgery.
Positive_regulation (measuring) of lactoferrin in heart
8) Confidence 0.43 Published 1994 Journal ASAIO J. Section Abstract Doc Link 8186493 Disease Relevance 0 Pain Relevance 0.09
In view of the morphological and functional similarities between the pancreatic and parotid glands, we have measured the immunoreactive lactoferrin concentration in pure parotid saliva of 30 patients with chronic calcific pancreatitis, 26 controls, 5 patients with proven pancreatic cancer, 2 patients with Sjögren's disease and 2 patients with chronic recurrent parotitis.
Positive_regulation (immunoreactive) of lactoferrin in saliva associated with parotitis, calcification, pancreatic cancer, pancreatitis and disease
9) Confidence 0.38 Published 1983 Journal Digestion Section Abstract Doc Link 6653928 Disease Relevance 1.03 Pain Relevance 0.38
RESULTS: Capsaicin-sensitive nerve stimulation produced increases in symptom scores and lactoferrin levels which were similar among the three groups of subjects.
Positive_regulation (increases) of lactoferrin in nerve
10) Confidence 0.31 Published 1998 Journal Clin. Exp. Allergy Section Body Doc Link 9537786 Disease Relevance 0.14 Pain Relevance 0
It was found that in chronic pancreatitis, viscosity, trypsin activity and lactoferrin concentration was also found to be increased, but the differences were not significant.
Positive_regulation (increased) of lactoferrin associated with chronic pancreatitis
11) Confidence 0.27 Published 1981 Journal Hepatogastroenterology Section Abstract Doc Link 7250899 Disease Relevance 0.26 Pain Relevance 0.38
These changes and loss of epithelium provide a likely explanation for increased release of serum proteins, immunoglobulins, and lactoferrin into the juice, and the possibility of luminal contents entering the extracellular space and bloodstream.
Spec (possibility) Positive_regulation (increased) of lactoferrin in epithelium
12) Confidence 0.20 Published 1997 Journal Int. J. Pancreatol. Section Abstract Doc Link 9209953 Disease Relevance 0.26 Pain Relevance 0.21
PAS staining was partially positive, and immunohistochemical staining for S-100 protein, lactoferrin, and amylase were also positive in cytoplasmic granules.
Positive_regulation (staining) of lactoferrin
13) Confidence 0.17 Published 2004 Journal Bull. Tokyo Dent. Coll. Section Abstract Doc Link 15536860 Disease Relevance 0.89 Pain Relevance 0.08
Consistent with this survival strategy of M.tuberculosis, lactoferrin (LTF) was induced in M.tuberculosis-infected lungs at D21.
Positive_regulation (induced) of lactoferrin in lungs associated with mycobacterial infection and infection
14) Confidence 0.15 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.45 Pain Relevance 0.04
RESULTS: Myeloperoxydase, lactoferrin and elastase levels remained unchanged following catheterization, whereas a significant increase in myeloperoxydase (P = 0.0009) and lactoferrin (P = 0.004) was observed after stenting.
Positive_regulation (increase) of lactoferrin
15) Confidence 0.11 Published 2005 Journal Coron. Artery Dis. Section Body Doc Link 15654202 Disease Relevance 0.08 Pain Relevance 0
Using a in vitro model of the BBB and in situ brain perfusion, they demonstrated that these peptides, and in particular Angiopep-2, exhibited higher transcytosis capacity and parenchymal accumulation than other receptors such as transferrin, lactoferrin, and avidin.
Positive_regulation (accumulation) of lactoferrin in brain
16) Confidence 0.10 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2847536 Disease Relevance 0.18 Pain Relevance 0
There is an increase in the levels of lactoferrin, beta(2)-microglobulin, sodium, lysozyme C, and cystatin C, and a decrease in salivary amylase and carbonic anhydrase.
Positive_regulation (se in th) of lactoferrin
17) Confidence 0.07 Published 2008 Journal J. Dent. Res. Section Abstract Doc Link 18362310 Disease Relevance 1.82 Pain Relevance 0.06
RESULTS: A significant elevation in myeloperoxidase and lactoferrin levels was observed after stenting in both group A (p<0.0001) and group B (p<0.0001), but was higher in group A.
Positive_regulation (elevation) of lactoferrin
18) Confidence 0.07 Published 2006 Journal Int. J. Cardiol. Section Body Doc Link 16316691 Disease Relevance 0.25 Pain Relevance 0
Markers for autoimmune pancreatitis are elevated serum IgG, especially IgG4, and autoantibodies to carbonic anhydrase (type II) and lactoferrin.
Positive_regulation (elevated) of lactoferrin associated with pancreatitis
19) Confidence 0.04 Published 2007 Journal J. Gastroenterol. Section Abstract Doc Link 17238031 Disease Relevance 0.86 Pain Relevance 0.44
Those studies conducted to date in cows undergoing normal or forced involution (ie, after sudden cessation of milking) have shown downregulation of mRNA abundance and concentration of enzymes related to the synthetic capacity of epithelial cells,7 downregulation of milk protein gene expression, upregulation of mRNA and synthesis of lactotransferrin,10,11 and upregulation of pro-apoptotic proteins (BAX) coupled with downregulation of beta integrins.8
Positive_regulation (upregulation) of lactotransferrin in epithelial cells associated with apoptosis
20) Confidence 0.03 Published 2010 Journal Bioinform Biol Insights Section Body Doc Link PMC2964046 Disease Relevance 0.49 Pain Relevance 0.03

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