INT45266

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Context Info
Confidence 0.38
First Reported 1983
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.46
Pain Relevance 3.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Nenf) extracellular region (Nenf)
Anatomy Link Frequency
spinal 1
brain 1
SCDH 1
Nenf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 6 100.00 Very High Very High Very High
Dorsal horn 4 100.00 Very High Very High Very High
excitatory amino acid 1 100.00 Very High Very High Very High
Gabapentin 11 99.72 Very High Very High Very High
Root ganglion neuron 4 99.68 Very High Very High Very High
IPN 2 99.48 Very High Very High Very High
Inflammation 8 99.14 Very High Very High Very High
opiate 2 98.64 Very High Very High Very High
Neuropathic pain 6 98.24 Very High Very High Very High
antagonist 1 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 4 99.54 Very High Very High Very High
Ganglion Cysts 4 99.48 Very High Very High Very High
Inflammatory Pain 2 99.48 Very High Very High Very High
Spinal Injuries 2 99.28 Very High Very High Very High
Neuropathic Pain 7 98.24 Very High Very High Very High
Low Back Pain 1 96.76 Very High Very High Very High
Hypersensitivity 3 95.76 Very High Very High Very High
Arthritis 1 93.44 High High
Referred Pain 1 91.84 High High
Frailty 3 90.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also examined gabapentin's effects at inhibiting hindpaw formalin-induced release of excitatory amino acids (EAAs) in the spinal cord dorsal horn (SCDH) both in naïve rats and in rats with neuropathic pain.
Spec (examined) Negative_regulation (inhibiting) of spinal cord dorsal horn in SCDH associated with neuropathic pain, dorsal horn, gabapentin, spinal cord and excitatory amino acid
1) Confidence 0.38 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16092950 Disease Relevance 0.81 Pain Relevance 1.95
Inflammatory pain mediated by a phenotypic switch in brain-derived neurotrophic factor-immunoreactive dorsal root ganglion neurons innervating the lumbar facet joints in rats.
Negative_regulation (switch) of brain-derived neurotrophic factor-immunoreactive in brain associated with ganglion cysts, facet joint, ipn and root ganglion neuron
2) Confidence 0.36 Published 2002 Journal Neurosci. Lett. Section Title Doc Link 11950510 Disease Relevance 1.00 Pain Relevance 1.01
In the cat, we have shown that beta-endorphin-like immunoreactivity was increased in plasma following traumatic spinal injury; such injury was associated with a decrease in spinal cord blood flow (SCBF) which was reversed by the opiate receptor antagonist naloxone.
Negative_regulation (decrease) of spinal cord blood flow in spinal associated with antagonist, injury, narcan, opiate, spinal injuries and spinal cord
3) Confidence 0.07 Published 1983 Journal Peptides Section Abstract Doc Link 6657511 Disease Relevance 0.64 Pain Relevance 0.63

General Comments

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