INT45275

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Context Info
Confidence 0.62
First Reported 1980
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 39
Total Number 41
Disease Relevance 9.39
Pain Relevance 5.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CSH1) extracellular region (CSH1)
Anatomy Link Frequency
skin 5
Median nerve 2
muscle 2
muscle fiber 2
VMO 2
CSH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 44 100.00 Very High Very High Very High
analgesia 34 100.00 Very High Very High Very High
epidural 11 100.00 Very High Very High Very High
Calcium channel 4 99.60 Very High Very High Very High
Bioavailability 69 99.20 Very High Very High Very High
intrathecal 2 98.96 Very High Very High Very High
cINOD 1 98.88 Very High Very High Very High
local anesthetic 2 98.48 Very High Very High Very High
corticosteroid 164 98.46 Very High Very High Very High
chemokine 92 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Organ Transplantation 23 99.78 Very High Very High Very High
Skin Cancer 4 99.36 Very High Very High Very High
INFLAMMATION 150 98.68 Very High Very High Very High
Hypersensitivity 66 98.68 Very High Very High Very High
Cockayne Syndrome 220 98.24 Very High Very High Very High
Contact Dermatitis 168 97.56 Very High Very High Very High
Targeted Disruption 8 97.16 Very High Very High Very High
Rheumatoid Arthritis 170 97.12 Very High Very High Very High
Pressure And Volume Under Development 39 96.96 Very High Very High Very High
Fibrosis 33 93.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to the classical sites of production, the pituitary (exclusively GH-N transcripts) and the placenta (PL-A/B > 99%, GH-V < 1%), radioactive semiquantitative restriction enzyme analysis of the PCR-products revealed, that the testis has its own organ-specific pattern of GH/PL gene expression: PL-A/B > GH-V > or = PL-L = GH-N.
Gene_expression (expression) of PL in pituitary
1) Confidence 0.62 Published 1997 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 9220021 Disease Relevance 0 Pain Relevance 0.07
To study the role of PRL in the regulation of the production of 17 beta-estradiol, progesterone, testosterone, and human placental lactogen (hPL), 11 healthy women were given 150 mg sulpiride daily for 14 days, beginning between weeks 6--9 of normal gestation.
Gene_expression (production) of placental lactogen
2) Confidence 0.59 Published 1980 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7380989 Disease Relevance 0 Pain Relevance 0
Compared with other techniques of neuraxial anesthesia, CSA allows incremental dosing of an intrathecal local anesthetic for an indefinite duration, whereas traditional single-shot spinal anesthesia usually involves larger doses, a finite, unpredictable duration, and greater potential for detrimental hemodynamic effects including hypotension, and epidural anesthesia via a catheter may produce lesser motor block and suboptimal anesthesia in sacral nerve root distributions.
Gene_expression (allows) of CSA in nerve associated with anesthesia, pressure volume 2 under development, epidural, local anesthetic and intrathecal
3) Confidence 0.57 Published 2009 Journal Am J Ther Section Abstract Doc Link 19546804 Disease Relevance 0.15 Pain Relevance 1.20
The latter findings prompted us to investigate a possible eutopic production of GH, placental lactogen (PL) and PRL in human testes.
Spec (possible) Gene_expression (production) of PL in testes
4) Confidence 0.54 Published 1997 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 9220021 Disease Relevance 0 Pain Relevance 0.09
Sulpiride treatment during early human pregnancy: effect on the levels of prolactin, six steroids, and placental lactogen.
Gene_expression (levels) of placental lactogen
5) Confidence 0.40 Published 1980 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 7380989 Disease Relevance 0.19 Pain Relevance 0.07
Cross sectional area (CSA)
Gene_expression (sectional) of CSA
6) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013134 Disease Relevance 0.07 Pain Relevance 0
Immortalized CSB (CS1AN) fibroblasts expressing either wild-type CSB cDNA (CSB-wt line) or enhanced green fluorescent protein (CSB-null line) were generated as described [25].
Gene_expression (expressing) of CS1AN in fibroblasts
7) Confidence 0.35 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2268245 Disease Relevance 0.52 Pain Relevance 0
And third, mouse models with either a truncating mutation similar to a severe human CSB allele (CS1AN; K337STOP) [55] or a CSA knockout [56] manifest the characteristic UV sensitivity of CS, as well as an unexpected susceptibility to skin cancer not observed for human CSB and CSA mutations, but only a subtle developmental phenotype.
Neg (not) Gene_expression (mutations) of CSA in skin associated with targeted disruption, skin cancer and cockayne syndrome
8) Confidence 0.31 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2268245 Disease Relevance 1.02 Pain Relevance 0.08
HeLa, WI38/hTERT, and CS1AN-derived lines were cultured in MEM?
Gene_expression (HeLa) of CS1AN in HeLa
9) Confidence 0.27 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2268245 Disease Relevance 0.39 Pain Relevance 0
Alternatively, the 3 anomalous patients (CS1PV, CS3PV, and CS10LO) may not express the fusion protein, but have other mutations or modifier genes which phenocopy the effect of the fusion protein.
Neg (not) Gene_expression (express) of CS1PV in CS1PV
10) Confidence 0.24 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2268245 Disease Relevance 0.42 Pain Relevance 0
50% elevation in [sR1]pl (peaking ?
Gene_expression (peaking) of pl
11) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0.07 Pain Relevance 0
Where [V]pl was within the experimental ranges of 1–2 pM, [V]IS were predicted to be ?
Gene_expression (was) of pl
12) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
Immediately after the onset of exercise, independent simulation of activity-dependent kL predicted that an elevation in [V]pl preceded the larger but slower elevation in [sR1]pl (Fig. 9B).
Gene_expression (preceded) of pl
13) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0.06 Pain Relevance 0
Muscle strength and CSA of quadriceps
Gene_expression (strength) of CSA in Muscle
14) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0 Pain Relevance 0
6) showed significant (P<0.05) decreases in type-I muscle fiber CSA following 14 D of immobilization, but only women showed a significant (P<0.05) decrease in type-IIa fiber CSA, and no significant changes in type-IIx fiber CSA were detected in either sex.


Gene_expression (detected) of CSA in muscle fiber
15) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.06 Pain Relevance 0
Men and women showed significant and nearly identical decreases in total muscle CSA after 14 D of immobilization (men?
Gene_expression (total) of CSA in muscle
16) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0 Pain Relevance 0
6) showed significant (P<0.05) decreases in type-I muscle fiber CSA following 14 D of immobilization, but only women showed a significant (P<0.05) decrease in type-IIa fiber CSA, and no significant changes in type-IIx fiber CSA were detected in either sex.


Gene_expression (following) of CSA in muscle fiber
17) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0 Pain Relevance 0
It must be noted that the bioavailability for Neoral and a number of the generic products of CsA exhibited marked pharmacokinetic variations in different human subpopulations even though they had been found bioequivalent.
Gene_expression (products) of CsA associated with bioavailability
18) Confidence 0.16 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2374933 Disease Relevance 0 Pain Relevance 0.21
In this study, investigators monitored and tried to maintain trough CSA levels between 150 and 250 ?
Gene_expression (levels) of CSA
19) Confidence 0.12 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697521 Disease Relevance 0 Pain Relevance 0
The CS-1 isoform of fibronectin is expressed on the luminal surface of the endothelium and by lining layer cells in RA synovia, with less expression occurring in control synovia [22,31,32].
Gene_expression (expressed) of CS-1 in endothelium associated with rheumatoid arthritis
20) Confidence 0.11 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 0.90 Pain Relevance 0.30

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