INT4528

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Context Info
Confidence 0.58
First Reported 1975
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 4.76
Pain Relevance 4.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Sell) plasma membrane (Sell)
Anatomy Link Frequency
neutrophils 3
plasma 2
T cells 2
CTL 1
Sell (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 9 99.60 Very High Very High Very High
cINOD 19 99.28 Very High Very High Very High
cOX1 2 98.06 Very High Very High Very High
reflex sympathetic dystrophy 7 98.04 Very High Very High Very High
agonist 20 97.64 Very High Very High Very High
abatacept 6 97.52 Very High Very High Very High
Inflammation 129 94.40 High High
cytokine 63 93.36 High High
Inflammatory response 27 91.04 High High
rheumatoid arthritis 4 89.44 High High
Disease Link Frequency Relevance Heat
Death 13 99.86 Very High Very High Very High
Cancer 22 99.76 Very High Very High Very High
Necrosis 12 99.52 Very High Very High Very High
Stress 58 99.40 Very High Very High Very High
INFLAMMATION 150 99.08 Very High Very High Very High
Complex Regional Pain Syndromes 7 98.04 Very High Very High Very High
Adhesions 36 97.64 Very High Very High Very High
Lymphopenia 7 96.88 Very High Very High Very High
General Immunology 28 94.64 High High
Injury 25 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Structure-function relationship and role of tumor necrosis factor-alpha-converting enzyme in the down-regulation of L-selectin by non-steroidal anti-inflammatory drugs.
Negative_regulation (down-regulation) of L-selectin associated with necrosis, inflammation, cancer, cinod and cox1
1) Confidence 0.58 Published 2002 Journal J. Biol. Chem. Section Title Doc Link 12147693 Disease Relevance 0.58 Pain Relevance 0.69
Diphenylamine-related compounds failed to down-regulate L-selectin in a tumor necrosis factor-alpha-converting enzyme (TACE)-deficient murine monocytic cell line.
Neg (failed) Negative_regulation (down-regulate) of L-selectin associated with necrosis and cancer
2) Confidence 0.58 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12147693 Disease Relevance 0.47 Pain Relevance 0.53
Ag-specific T cell proliferation was reduced, and the acquisition of an activated phenotype, characterized by upregulation of CD69, OX40, ICOS, and programmed death-1 and downregulation of CD62L, was suppressed.
Negative_regulation (downregulation) of CD62L in T cell associated with death
3) Confidence 0.33 Published 2010 Journal J. Immunol. Section Abstract Doc Link 20601593 Disease Relevance 0.59 Pain Relevance 0.76
Despite severe decreases in splenic T cell numbers, there was no upregulation of CD44 or downregulation of CD62L in spleen (Figure 3C), changes that characterize T cells that have undergone lymphopenia-induced homeostatic proliferation.
Negative_regulation (downregulation) of CD62L in T cells associated with lymphopenia
4) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.32 Pain Relevance 0.08
Blocking alpha4-integrin, P-selectin, or L-selectin had no significant effect on sinusoidal or postsinusoidal adhesion.
Negative_regulation (Blocking) of L-selectin associated with adhesions
5) Confidence 0.24 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17656447 Disease Relevance 0.52 Pain Relevance 0.21
LPS induced a significant activation of lung-marginated neutrophils, promoting shedding of L-selectin (i.e. reduced expression), and upregulation of CD11b.
Negative_regulation (shedding) of L-selectin in neutrophils
6) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903490 Disease Relevance 0.12 Pain Relevance 0.04
We evaluated a recently reported screening test for IRAK-4 deficiency based on the downregulation of CD62L (L-selectin) on blood neutrophils (PMN) upon Toll-like receptor (TLR) agonist stimulation with two known IRAK-4-deficient patients and a newborn sibling.
Negative_regulation (downregulation) of L-selectin in neutrophils associated with agonist
7) Confidence 0.14 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.17 Pain Relevance 0.24
We evaluated a recently reported screening test for IRAK-4 deficiency based on the downregulation of CD62L (L-selectin) on blood neutrophils (PMN) upon Toll-like receptor (TLR) agonist stimulation with two known IRAK-4-deficient patients and a newborn sibling.
Negative_regulation (downregulation) of CD62L in neutrophils associated with agonist
8) Confidence 0.14 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.17 Pain Relevance 0.23
However, post-treatment with inhibitors of L-selectin using monoclonal antibodies shows no improvement of lesion size in rabbits subjected to 2 hours occlusion [121].
Negative_regulation (inhibitors) of L-selectin
9) Confidence 0.05 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 0.60 Pain Relevance 0.07
As compared with healthy volunteers, the following major alterations in CRPS patients were found: (I) elevated stress score (PTSS-10) and stress hormone concentrations, (II) decreased expression of the CD62L and CD11b/CD18 on neutrophils, (III) impaired ability of autologous plasma to enhance the capability of neutrophils to phagocytose zymosan particles, and (IV) a negative correlation between PTSS-10 values and autologous plasma enhanced phagocytosis.
Negative_regulation (decreased) of CD62L in plasma associated with stress and reflex sympathetic dystrophy
10) Confidence 0.05 Published 2007 Journal Clin. Immunol. Section Abstract Doc Link 17702656 Disease Relevance 1.22 Pain Relevance 0.81
Lymph-plasma protein ratios decreased linearly with increasing lymph flow during increased pressure experiments, but during histamine infusions the ratios did not decrease even though lymph flow increased 2-6-fold.
Negative_regulation (decreased) of Lymph-plasma in plasma
11) Confidence 0.04 Published 1975 Journal Circ. Res. Section Abstract Doc Link 1192562 Disease Relevance 0 Pain Relevance 0.08
Previous studies have shown morphine (50.0 mg/kg, s.c.) suppresses cytotoxic T lymphocyte (CTL) activity in alloimmunized mice.
Negative_regulation (suppresses) of lymphocyte in CTL associated with morphine
12) Confidence 0.01 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8768756 Disease Relevance 0 Pain Relevance 0.47

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