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Context Info
Confidence 0.07
First Reported 1983
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.11
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Pomc, ENG) extracellular space (Pomc, ENG) cell-cell signaling (Pomc)
generation of precursor metabolites and energy (Pomc) signal transduction (Pomc) extracellular region (Pomc)
Anatomy Link Frequency
immune cells 1
lobe 1
Pomc (Rattus norvegicus)
ENG (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 6 100.00 Very High Very High Very High
Dynorphin 3 99.46 Very High Very High Very High
Enkephalin 11 99.02 Very High Very High Very High
opioid receptor 18 97.40 Very High Very High Very High
Opioid 43 90.96 High High
Hyperalgesia 22 86.40 High High
antinociception 10 85.60 High High
antagonist 2 78.16 Quite High
agonist 5 75.00 Quite High
Endogenous opioid 9 74.96 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 50 98.52 Very High Very High Very High
Nociception 16 82.76 Quite High
Cold Sores 14 74.56 Quite High
INFLAMMATION 18 73.36 Quite High
Pain 16 62.56 Quite High
Hepatocellular Cancer 2 38.00 Quite Low
Hepatitis 4 36.44 Quite Low
Bordatella Infection 2 27.84 Quite Low
Neuropathic Pain 4 23.80 Low Low
Inflammatory Pain 20 22.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In some of our experiments POMC-MIDGE-NLS slightly elevated END content in immune cells accumulating in inflamed tissue.
POMC-MIDGE-NLS Positive_regulation (elevated) of END in immune cells
1) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2797781 Disease Relevance 0.75 Pain Relevance 0.38
The fact that Abs recognizing endogenous END were reactive in our immunohistochemical and RIA experiments suggests that POMC-MIDGE-NLS-induced END is not different from authentic END and therefore should act at opioid receptors.
POMC-MIDGE-NLS Positive_regulation (induced) of END associated with opioid receptor
2) Confidence 0.06 Published 2009 Journal Mol Pain Section Body Doc Link PMC2797781 Disease Relevance 0.35 Pain Relevance 0.56
(D-Ala2,D-Leu5)-enkephalin (5 microM), dynorphin-(1-13) (Dyn; 0.2 microM), beta-endorphin (beta-End; 0.02 and 0.2 microM) and also naloxone (1 or 10 microM) increased the evoked vasopressin release from the neurointermediate lobe, but in higher concentrations (2 microM) Dyn or beta-End had no effect.
beta-endorphin Positive_regulation (increased) of beta-End in lobe associated with dynorphin, narcan and enkephalin
3) Confidence 0.00 Published 1983 Journal Life Sci. Section Abstract Doc Link 6664231 Disease Relevance 0 Pain Relevance 0.74

General Comments

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