INT45324

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Context Info
Confidence 0.59
First Reported 1983
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.94
Pain Relevance 3.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Otc) cytoplasm (Otc)
Anatomy Link Frequency
liver 2
plasma 1
Otc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Analgesic 6 100.00 Very High Very High Very High
Glutamate 6 100.00 Very High Very High Very High
Arthritis 10 99.80 Very High Very High Very High
Rheumatism 9 99.24 Very High Very High Very High
adenocard 2 99.22 Very High Very High Very High
cINOD 12 95.92 Very High Very High Very High
cryotherapy 76 90.32 High High
Paracetamol 8 88.92 High High
tolerance 6 88.16 High High
Inflammation 9 82.00 Quite High
Disease Link Frequency Relevance Heat
Arthritis 10 99.80 Very High Very High Very High
Rheumatic Diseases 11 99.24 Very High Very High Very High
Toxicity 4 95.68 Very High Very High Very High
Occupational Lung Diseases 2 93.44 High High
Chronic Disease 14 93.20 High High
INFLAMMATION 11 91.20 High High
Sprains And Strains 1 90.48 High High
Body Weight 3 88.24 High High
Hepatotoxicity 6 87.04 High High
Adverse Drug Reaction 1 86.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Urea synthesis alone requires five enzymes (arginosuccinate lyase, arginosuccinate synthetase, arginase, ornithine transcarbamoylase, and carbamoyl phosphate synthetase).
Positive_regulation (requires) of ornithine transcarbamoylase
1) Confidence 0.59 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0.61 Pain Relevance 0.15
A linear stimulation constant (Model D) was sufficient to describe the biosignal mediated increase in OTC, alanine aminotransferase(ALT) and carbamoyl phosphate synthetase (CPS).
Positive_regulation (increase) of OTC
2) Confidence 0.51 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0 Pain Relevance 0.08
Over the counter (OTC) oral remedies for arthritis and rheumatism: how effective are they?
Positive_regulation (remedies) of OTC associated with rheumatism and arthritis
3) Confidence 0.44 Published 1999 Journal Inflammopharmacology Section Title Doc Link 18597151 Disease Relevance 0.72 Pain Relevance 0.53
The use of OTC and Rx medication increased by number of physician visits for women and men.
Positive_regulation (increased) of OTC
4) Confidence 0.36 Published 2004 Journal BMC Womens Health Section Abstract Doc Link PMC2096677 Disease Relevance 0.09 Pain Relevance 0
Among women with high educational levels who have children there is a decreased likelihood of medication use (in both medication use groups), whereas among both women and men with low educational levels, having children in the household increases the reported medication use (Rx and OTC group).
Positive_regulation (increases) of OTC
5) Confidence 0.36 Published 2004 Journal BMC Womens Health Section Body Doc Link PMC2096677 Disease Relevance 0.11 Pain Relevance 0.06
Supplementary over-the-counter (OTC) and prescription analgesics were required by 72 and 59% of patients, respectively, while OTC and prescription gastroprotective agents to treat NSAID toxicity were required by 35 and 30%.
Positive_regulation (required) of OTC associated with toxicity, analgesic and cinod
6) Confidence 0.34 Published 2002 Journal Rheumatology (Oxford) Section Abstract Doc Link 12173277 Disease Relevance 1.00 Pain Relevance 1.25
In the liver, glutathione content decreased throughout the observation periods, and glutathione S-transferase initially, and later adenosine triphosphatase decreased, followed as elevations of aminotransferases and ornithione carbamoyltransferase in serum.
Positive_regulation (elevations) of ornithione carbamoyltransferase in liver associated with adenocard
7) Confidence 0.09 Published 1983 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 6665301 Disease Relevance 0.52 Pain Relevance 0.43
Statistically significant increases in the activities of glutamate dehydrogenase, sorbitol dehydrogenase, malate dehydrogenase, ornithine transcarbamoylase, and arginase were observed in the plasma and liver.
Positive_regulation (increases) of ornithine transcarbamoylase in plasma associated with glutamate
8) Confidence 0.01 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2734249 Disease Relevance 0.44 Pain Relevance 0.43
Statistically significant increases in the activities of glutamate dehydrogenase, sorbitol dehydrogenase, malate dehydrogenase, ornithine transcarbamoylase, and arginase were observed in the plasma and liver.
Positive_regulation (increases) of ornithine transcarbamoylase in liver associated with glutamate
9) Confidence 0.00 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2734249 Disease Relevance 0.44 Pain Relevance 0.43

General Comments

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