INT45332

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Context Info
Confidence 0.37
First Reported 1983
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.06
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abat)
Anatomy Link Frequency
synapse 2
Abat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 29 100.00 Very High Very High Very High
GABA receptor 3 97.20 Very High Very High Very High
antagonist 3 91.16 High High
agonist 4 90.56 High High
dopamine receptor 1 90.20 High High
potassium channel 1 63.00 Quite High
antiepileptic Drug 33 52.40 Quite High
anticonvulsant 6 47.76 Quite Low
carbamazepine 7 32.76 Quite Low
nMDA receptor 3 30.64 Quite Low
Disease Link Frequency Relevance Heat
Convulsion 125 94.64 High High
Syndrome 140 94.04 High High
Epilepsy 97 90.40 High High
Pancreatitis 1 79.12 Quite High
Toxicity 3 78.48 Quite High
Infantile Spasms 9 58.24 Quite High
Scotoma 1 54.80 Quite High
Cognitive Disorder 6 25.36 Quite Low
Syncope 10 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the possibility that GBL inhibits GABA degradation is not excluded, the compound appears to increase the sensitivity of GABA receptor to GABA mimetics in the gastric acid secretion.
Negative_regulation (inhibits) of Protein_catabolism (degradation) of GABA associated with gaba and gaba receptor
1) Confidence 0.37 Published 1983 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 6668764 Disease Relevance 0 Pain Relevance 0.83
VGB’s main actions are on the GABA-ergic synapse as an irreversible inhibitor of the GABA-degrading enzyme, GABA transaminase.
Negative_regulation (inhibitor) of Protein_catabolism (degrading) of GABA transaminase in synapse associated with gaba
2) Confidence 0.07 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646636 Disease Relevance 1.06 Pain Relevance 0.26

General Comments

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