INT4534

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Context Info
Confidence 0.33
First Reported 1975
Last Reported 2010
Negated 4
Speculated 3
Reported most in Abstract
Documents 38
Total Number 42
Disease Relevance 19.81
Pain Relevance 8.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PROC) extracellular space (PROC) extracellular region (PROC)
plasma membrane (PROC)
Anatomy Link Frequency
posterior 2
cerebellum 2
bile 2
BLA 1
neurite 1
PROC (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 24 100.00 Very High Very High Very High
amygdala 11 100.00 Very High Very High Very High
Paracetamol 10 100.00 Very High Very High Very High
Neuropeptide 11 99.96 Very High Very High Very High
cytokine 67 99.92 Very High Very High Very High
Hippocampus 37 99.78 Very High Very High Very High
Thalamus 11 99.70 Very High Very High Very High
monoamine 2 99.64 Very High Very High Very High
Bile 19 99.60 Very High Very High Very High
Pain 24 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Prostate Cancer 54 100.00 Very High Very High Very High
Malignant Neoplastic Disease 2 100.00 Very High Very High Very High
Adhesions 18 99.68 Very High Very High Very High
Disease 144 99.58 Very High Very High Very High
Pain 23 99.52 Very High Very High Very High
INFLAMMATION 190 99.24 Very High Very High Very High
Pneumonia 98 99.20 Very High Very High Very High
Pseudomonas Infection 65 99.04 Very High Very High Very High
Adult Respiratory Distress Syndrome 86 98.96 Very High Very High Very High
Reprotox - General 1 7 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Therapeutic effect of sulfobenzyl-penicillin (SB-PC) on the concentration of SB-PC in human bile (author's transl)].
Regulation (effect) of SB-PC in bile associated with bile
1) Confidence 0.33 Published 1975 Journal Jpn J Antibiot Section Title Doc Link 1195516 Disease Relevance 0.73 Pain Relevance 0.22
Pressure conditioning does not modify anesthesia tolerance, unlike N2 habituation which affects anesthesia threshold pressure as well as Pc.
Regulation (affects) of Pc associated with anesthesia and tolerance
2) Confidence 0.26 Published 1986 Journal J. Appl. Physiol. Section Abstract Doc Link 3804908 Disease Relevance 0.23 Pain Relevance 0.37
If PC was administered simultaneously with ascorbic acid (AA), also in a dose of 3 X 1000 mg, a decreased level of UDS was observed after 24, 72 and 168 h and the increased number of micronuclei was qualitatively the same as the PC alone: 0.38 +/- 0.09% after 72 h vs. 0.20 +/- 0.05% at 0 h AA did not decrease the genotoxic effect of PC, but prolonged the influence of PC on UDS.
Regulation (influence) of PC associated with paracetamol
3) Confidence 0.24 Published 1989 Journal Mutat. Res. Section Abstract Doc Link 2811932 Disease Relevance 0 Pain Relevance 0.79
The entire effect thus appears to be an extension in time of the monoaminergic compression rate effect on Pc.
Regulation (effect) of Pc associated with monoamine
4) Confidence 0.23 Published 1986 Journal J. Appl. Physiol. Section Abstract Doc Link 3804908 Disease Relevance 0.24 Pain Relevance 0.36
[Therapeutic effect of sulfobenzyl-penicillin (SB-PC) on the concentration of SB-PC in human bile (author's transl)].
Regulation (effect) of SB-PC in bile associated with bile
5) Confidence 0.20 Published 1975 Journal Jpn J Antibiot Section Title Doc Link 1195516 Disease Relevance 0.72 Pain Relevance 0.22
Transcriptional factors are involved in the expression of endothelial adhesion molecules, and regulation of activity of these factors (i.e., NF-kappa B) is a very attractive target for therapeutic interventions.
Regulation (regulation) of factors associated with adhesions
6) Confidence 0.15 Published 2001 Journal Hepatogastroenterology Section Abstract Doc Link 11462918 Disease Relevance 0.97 Pain Relevance 0.23
This article reports on a study that examines the influence of task-related factors on nurses' pain assessments and decision regarding interventions.
Spec (examines) Regulation (influence) of factors associated with pain
7) Confidence 0.15 Published 1996 Journal Pain Section Abstract Doc Link 8826490 Disease Relevance 0.38 Pain Relevance 0.52
Therefore, we speculated that the increase in cardiac interstitial NA levels induced by PC may be modified by the anesthesia used, thus regulating the effect of glibenclamide on the PC effect.
Regulation (regulating) of PC associated with anesthesia and noradrenaline
8) Confidence 0.14 Published 1997 Journal Heart Vessels Section Abstract Doc Link 9860197 Disease Relevance 0.23 Pain Relevance 0.86
After CTb injections in the Pc, a large number of retrogradely labeled neurons were seen in the central nucleus of the amygdala, the lateral part of the bed nucleus of the stria terminalis, the posterior hypothalamic areas, the mesencephalic reticular formation, the nucleus locus subcoeruleus, the nucleus pontis caudalis, other portions of the Pc, the nucleus reticularis dorsalis, the trigeminal sensory complex, and the nucleus of the solitary tract.
Regulation (seen) of Pc in posterior associated with amygdala
9) Confidence 0.14 Published 1994 Journal J. Comp. Neurol. Section Abstract Doc Link 7518846 Disease Relevance 0.29 Pain Relevance 0.36
After CTb injections in the Pc, a large number of retrogradely labeled neurons were seen in the central nucleus of the amygdala, the lateral part of the bed nucleus of the stria terminalis, the posterior hypothalamic areas, the mesencephalic reticular formation, the nucleus locus subcoeruleus, the nucleus pontis caudalis, other portions of the Pc, the nucleus reticularis dorsalis, the trigeminal sensory complex, and the nucleus of the solitary tract.
Regulation (seen) of Pc in posterior associated with amygdala
10) Confidence 0.14 Published 1994 Journal J. Comp. Neurol. Section Abstract Doc Link 7518846 Disease Relevance 0.17 Pain Relevance 0.17
All values of PC levels, APC levels, and the APC/PC ratio during the hospital stay are shown in Figure 1a–c.
Regulation (values) of PC
11) Confidence 0.13 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.08 Pain Relevance 0
In children with meningococceal sepsis, on the other hand, patients' ability to generate APC in response to thrombin did not seem to be grossly affected as infusion of PC resulted in elevated levels of APC, and significant correlations were observed between APC and thrombin markers at baseline [17].
Regulation (affected) of PC associated with sepsis
12) Confidence 0.13 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.23 Pain Relevance 0
Concomitant rhAPC administration was responsible for a significant alteration of this parameter.
Regulation (responsible) of rhAPC
13) Confidence 0.07 Published 2006 Journal Respir Res Section Body Doc Link PMC1435891 Disease Relevance 1.16 Pain Relevance 0
Human factors were responsible for 70.6% of critical incidents and 71.1% of deaths.


Regulation (responsible) of factors
14) Confidence 0.05 Published 2005 Journal Masui Section Body Doc Link 16104558 Disease Relevance 0 Pain Relevance 0
The aim of the study was to examine the effects of recombinant human activated protein C (rhAPC) in the early phase of Pseudomonas aeruginosa (Pa)-induced lung injury.


Spec (examine) Regulation (effects) of rhAPC in lung associated with lung injury and pseudomonas infection
15) Confidence 0.05 Published 2006 Journal Respir Res Section Abstract Doc Link PMC1435891 Disease Relevance 1.05 Pain Relevance 0.13
The incremental risk suggests that the risk of DVT may be related to the interaction between drugs and their collective effect on malignant cells and some others events such as APC-R or the vascular endothelium [5].
Regulation (effect) of APC-R in vascular endothelium associated with malignant neoplastic disease and thrombosis
16) Confidence 0.04 Published 2006 Journal Thromb J Section Body Doc Link PMC1564129 Disease Relevance 1.26 Pain Relevance 0.05
This evidence as well as published data that show the effects of PC SPES in suppressing growth of prostate cancer in animal model studies, is reviewed together with the available data on the possible side effects of PC SPES.
Regulation (effects) of PC SPES associated with reprotox - general 1
17) Confidence 0.03 Published 2000 Journal Int. J. Oncol. Section Abstract Doc Link 10995884 Disease Relevance 0.44 Pain Relevance 0.06
The positive influence of PC on HRQoL has been demonstrated in several trials [8,9].
Regulation (influence) of PC
18) Confidence 0.03 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC2894785 Disease Relevance 0.38 Pain Relevance 0
Remarkably, animal studies revealed beneficial effects on gastrointestinal damage not only for PC but also for selected lysophospholipids.
Regulation (effects) of PC
19) Confidence 0.03 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996791 Disease Relevance 0.97 Pain Relevance 0.31
Other parameters (age, gestational age, ATIII, fPS, PC and APC values) were not significantly different between these two groups (Table 2).


Regulation (values) of PC
20) Confidence 0.03 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2999706 Disease Relevance 0 Pain Relevance 0

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