INT4535

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Context Info
Confidence 0.73
First Reported 1975
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 106
Total Number 108
Disease Relevance 76.24
Pain Relevance 21.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PROC) extracellular space (PROC) extracellular region (PROC)
plasma membrane (PROC)
Anatomy Link Frequency
osteoclasts 9
platelets 4
macrophages 3
chromaffin cells 3
Plasma 3
PROC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 479 100.00 Very High Very High Very High
palliative 320 100.00 Very High Very High Very High
cytokine 186 100.00 Very High Very High Very High
chemokine 37 100.00 Very High Very High Very High
Analgesic 6 100.00 Very High Very High Very High
Neuropeptide 9 99.80 Very High Very High Very High
Inflammatory response 55 99.74 Very High Very High Very High
qutenza 13 99.68 Very High Very High Very High
Migraine 3 99.56 Very High Very High Very High
Bile 58 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 524 100.00 Very High Very High Very High
Prostate Cancer 243 100.00 Very High Very High Very High
Osteoporosis 94 100.00 Very High Very High Very High
Pancreatic Cancer 85 100.00 Very High Very High Very High
Obesity 42 100.00 Very High Very High Very High
Hypertension 38 100.00 Very High Very High Very High
Colitis 13 100.00 Very High Very High Very High
Overweight 6 100.00 Very High Very High Very High
Cancer 563 99.98 Very High Very High Very High
Death 142 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein C and Protein S are reduced at birth to 30% of adult plasma concentrations and remain decreased during the first weeks of life [5].
Localization (decreased) of Protein C in plasma
1) Confidence 0.73 Published 2006 Journal Thromb J Section Body Doc Link PMC1533804 Disease Relevance 0.55 Pain Relevance 0.04
Several probable roles for this cell type in the second phase of recovery, involving resolution processes, have been identified and include the following: (i) phagocytosis to remove cellular debris; (ii) switching from a pro- to anti-inflammatory phenotype in regenerating muscle; (iii) preventing muscle cells from undergoing apoptosis; (iv) releasing factors to promote muscle precursor cell activation and growth; and (v) secretion of cytokines and growth factors to facilitate vascular and muscle fibre repair.
Localization (secretion) of factors in muscle cells associated with inflammation, apoptosis and cytokine
2) Confidence 0.67 Published 2008 Journal Sports Med Section Abstract Doc Link 18937524 Disease Relevance 1.04 Pain Relevance 0.33
Several probable roles for this cell type in the second phase of recovery, involving resolution processes, have been identified and include the following: (i) phagocytosis to remove cellular debris; (ii) switching from a pro- to anti-inflammatory phenotype in regenerating muscle; (iii) preventing muscle cells from undergoing apoptosis; (iv) releasing factors to promote muscle precursor cell activation and growth; and (v) secretion of cytokines and growth factors to facilitate vascular and muscle fibre repair.
Localization (releasing) of factors in muscle cells associated with inflammation, apoptosis and cytokine
3) Confidence 0.67 Published 2008 Journal Sports Med Section Abstract Doc Link 18937524 Disease Relevance 0.99 Pain Relevance 0.33
A range of issues were identified by both carers and patients as priorities for PC research.
Localization (research) of PC associated with pancreatic cancer
4) Confidence 0.60 Published 2010 Journal Cancer Causes Control Section Body Doc Link PMC2855814 Disease Relevance 0.53 Pain Relevance 0
AP seems to be an early presentation of PC and should be sought in patients with idiopathic pancreatitis.
Localization (presentation) of PC associated with pancreatic cancer and pancreatitis
5) Confidence 0.58 Published 2000 Journal Pancreas Section Abstract Doc Link 11075985 Disease Relevance 1.89 Pain Relevance 0.03
The treatment of typhoid carriers with cholelithiasis may belong to a most difficult problem. 3) Biliary excretion of SB-PC in the patient given a single dose of 2.0 g/day im. was markedly dependent on characteristics of the patient, situation of external drainage and volume of bile excretion.
Localization (excretion) of SB-PC in bile associated with bile, gallstones and typhoid fever
6) Confidence 0.52 Published 1975 Journal Jpn J Antibiot Section Abstract Doc Link 1195516 Disease Relevance 0.93 Pain Relevance 0.31
The purpose of this study was to evaluate effect of SB-PC on Salmonella typhosa and biliary excretion of SB-PC in disease of the biliary tract. 1) Clinically, typhoid carriers without cholelithiasis were initiated with 4.0 g/day of SB-PC.
Localization (excretion) of SB-PC in biliary tract associated with gallstones, disease and typhoid fever
7) Confidence 0.52 Published 1975 Journal Jpn J Antibiot Section Abstract Doc Link 1195516 Disease Relevance 0.73 Pain Relevance 0.12
Four coils—2 × 9 mm (Boston Scientific, Cork, Ireland), 1 × 12 mm, and 1 × 15 mm (Cook, Bjaeverskov, Denmark)—were placed selectively in the side-branch of the IIA (Fig. 2b).
Localization (branch) of IIA
8) Confidence 0.48 Published 2007 Journal Cardiovasc Intervent Radiol Section Body Doc Link PMC1964782 Disease Relevance 0.55 Pain Relevance 0.07
We prepared from a unit of whole blood, platelet-leukocyte gel (PLG) to stimulate bone formation, based on the release of platelet growth factors.
Localization (release) of factors in platelet
9) Confidence 0.44 Published 2010 Journal J Biomed Mater Res A Section Abstract Doc Link 19274712 Disease Relevance 0 Pain Relevance 0
Plasma samples supplemented with benzamidine, a reversible inhibitor of thrombin, APC, and trypsin-like proteases, were incubated in the wells for the capture of APC and PC.
Localization (capture) of PC in Plasma
10) Confidence 0.37 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.13 Pain Relevance 0
Recent studies on glia have shown that they prolong a state of neuronal hypersensitization in the dorsal root ganglia by releasing growth factors and other substances that act on the immune system.
Localization (releasing) of factors in immune system
11) Confidence 0.35 Published 2010 Journal Metab. Clin. Exp. Section Abstract Doc Link 20837196 Disease Relevance 1.26 Pain Relevance 1.10
Since it has been shown that monocytes/ macrophage release a cocktail of chemokines, growth factors and proteases involved in vascular growth, their contribution seems to be of a paracrine fashion.
Localization (release) of factors in macrophage associated with chemokine
12) Confidence 0.31 Published 2006 Journal J. Cell. Mol. Med. Section Abstract Doc Link 16563221 Disease Relevance 0.28 Pain Relevance 0.11
Tumor cells metastatic to bone can also secrete growth factors, leading to increased osteoblastic activity.
Localization (secrete) of factors associated with cancer and osteoporosis
13) Confidence 0.31 Published 2007 Journal Clin. Breast Cancer Section Abstract Doc Link 17683652 Disease Relevance 1.50 Pain Relevance 0.18
Although the mechanism by which this mechanical treatment effects an alteration in cellular processes within the myocardium remains unclear, recent scientific investigations suggest that shear stress induced by chronic exposure to EECP might result in the release of a variety of growth factors and the subsequent stimulation of angiogenesis in the coronary beds.
Localization (release) of factors in myocardium associated with stress
14) Confidence 0.31 Published 1999 Journal Clin Cardiol Section Abstract Doc Link 10084058 Disease Relevance 0.43 Pain Relevance 0.08
In favourable statement such as the decreased activation of NK cells, the variable secretions of cytokines, pelvic macrophages and growth factors, the peritoneal implants evoluted like a progressive disease until severe endometriosis.
Localization (secretions) of factors in macrophages associated with endometriosis, disease and cytokine
15) Confidence 0.31 Published 1999 Journal Rev Prat Section Abstract Doc Link 10189793 Disease Relevance 1.16 Pain Relevance 0.70
The osteoclasts also release growth factors that can act back on the cancer cells to activate growth.
Localization (release) of factors in osteoclasts associated with cancer
16) Confidence 0.31 Published 2006 Journal Clin. Cancer Res. Section Abstract Doc Link 17062718 Disease Relevance 1.08 Pain Relevance 0.09
In the process of bone metastasis, the primary mechanism responsible for bone destruction is cancer cell-mediated stimulation of osteoclastic bone resorption, which results in osteolysis and release of various growth factors from the bone matrix.
Localization (release) of factors associated with cancer, osteolysis, hypercalcemia, osteoporosis and metastasis
17) Confidence 0.31 Published 2007 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 17220661 Disease Relevance 1.39 Pain Relevance 0.09
In cell culture, these cells have been shown to be metabolically dynamic, synthesizing and secreting extracellular matrix proteins, glycosaminoglycans and a wide variety of cell-cell signaling proteins, such as interleukins, chemokines and peptide growth factors.
Localization (secreting) of factors in extracellular matrix associated with chemokine
18) Confidence 0.31 Published 2004 Journal Bioessays Section Abstract Doc Link 15170862 Disease Relevance 0.63 Pain Relevance 0.23
The patients who had ASA classification below 3 were allocated to elective or emergency surgery and the patients who had ASA classification 3 or greater were allocated to PC as a bridge procedure before elective cholecystectomy (bridge group) and as a palliative procedure (palliation group) depending on clinical situation.
Localization (allocated) of PC in bridge associated with emergencies and palliative
19) Confidence 0.31 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2880266 Disease Relevance 0.77 Pain Relevance 0.37
Recent studies suggest that the peritoneal fluid of women with endometriosis contains an increased number of activated macrophages and other immune cells that secrete various local products, such as growth factors and cytokines, which exert a paracrine action on endometriotic cells.
Localization (secrete) of factors in immune cells associated with endometriosis and cytokine
20) Confidence 0.30 Published 2007 Journal Gynecol. Endocrinol. Section Abstract Doc Link 17952762 Disease Relevance 0.99 Pain Relevance 0.34

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