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Context Info
Confidence 0.67
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.48
Pain Relevance 3.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
plasma 1
testes 1
nucleus 1
preoptic region 1

Pain Term Frequency Confidence Heat
Cholecystokinin 6 100.00 Very High Very High Very High
Enkephalin 10 100.00 Very High Very High Very High
Somatostatin 1 100.00 Very High Very High Very High
bradykinin 1 100.00 Very High Very High Very High
Dynorphin 2 99.88 Very High Very High Very High
Rostral ventromedial medulla 3 99.70 Very High Very High Very High
Opioid 2 99.66 Very High Very High Very High
Neuropeptide 11 99.44 Very High Very High Very High
Inflammation 6 99.24 Very High Very High Very High
nud 26 98.68 Very High Very High Very High
Disease Term Frequency Confidence Heat
INFLAMMATION 5 99.24 Very High Very High Very High
Dyspepsia 26 98.68 Very High Very High Very High
Hyperalgesia 5 92.12 High High
Malabsorption Syndromes 47 92.12 High High
Middle Cerebral Artery Infarction 2 87.36 High High
Generalized Anxiety Disorder 3 86.68 High High
Pain 6 84.32 Quite High
Body Weight 1 77.56 Quite High
Cv Unclassified Under Development 1 69.44 Quite High
Urological Neuroanatomy 1 66.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The amygdalar neurochemical changes, including neuropeptide Y increase in the basolateral nucleus and leucine-enkephalin, dynorphin, and neurotensin increase in the central nucleus, were seen only when the ipsilateral insular cortex was lesioned.
Positive_regulation (increase) of neurotensin in nucleus associated with dynorphin, neuropeptide and enkephalin
1) Confidence 0.67 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 8636466 Disease Relevance 0.21 Pain Relevance 0.69
The pathophysiology of the Dysmotility type dyspepsia has been attributed to autoimmune damage to autonomous system or increase in neurotensin or enteroglucagon levels which impair gastrointestinal motility [15, 16, 18].
Positive_regulation (increase) of neurotensin associated with nud
2) Confidence 0.67 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995907 Disease Relevance 0.84 Pain Relevance 0.14
Naloxone infusion increased plasma pancreatic polypeptide secretion during the 1st hour of surgery and reversed the decline in plasma motilin concentrations, but had no effect on circulating somatostatin, vasoactive intestinal polypeptide, gastrin, enteroglucagon and neurotensin values.
Positive_regulation (circulating) of neurotensin in plasma associated with somatostatin and narcan
3) Confidence 0.49 Published 1983 Journal Clin Physiol Section Abstract Doc Link 6682026 Disease Relevance 0.08 Pain Relevance 0.54
The rabbit brain endooligopeptidase A and the rat testes soluble metallopeptidase (EC are thiol-activated oligopeptidases which are able to generate enkephalin from a number of opioid peptides and to inactivate bradykinin and neurotensin by hydrolyzing the same peptide bonds.
Positive_regulation (inactivate) of neurotensin in testes associated with enkephalin, bradykinin and opioid
4) Confidence 0.49 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10694468 Disease Relevance 0 Pain Relevance 0.29
Descending inhibition and facilitation during peripheral inflammation are due not only to previously existing descending modulation, but also to inflammation-induced changes in RVM which involve receptors for NMDA, AMPA, cholecystokinin and neurotensin, as well as synthesis of enkephalins and nitric oxide.
Positive_regulation (receptors) of neurotensin in RVM associated with inflammation, enkephalin, cholecystokinin and rostral ventromedial medulla
5) Confidence 0.49 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15135934 Disease Relevance 1.14 Pain Relevance 1.32
Distribution of glutamic acid decarboxylase, neurotensin, enkephalin, neuropeptide Y, and cholecystokinin neurons in the septo-preoptic region of male rats.
Positive_regulation (Distribution) of neurotensin in preoptic region associated with neuropeptide, enkephalin and cholecystokinin
6) Confidence 0.45 Published 2003 Journal J. Reprod. Dev. Section Title Doc Link 14967951 Disease Relevance 0.21 Pain Relevance 0.72

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