INT45365

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Context Info
Confidence 0.57
First Reported 1983
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 68
Total Number 72
Disease Relevance 25.44
Pain Relevance 32.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Cfp) cellular_component (Cfp) biological_process (Cfp)
Anatomy Link Frequency
PFC 9
amygdala 4
medial 3
brain 2
prefrontal 2
Cfp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 574 100.00 Very High Very High Very High
Hippocampus 303 100.00 Very High Very High Very High
Nucleus accumbens 239 100.00 Very High Very High Very High
Dopamine 152 100.00 Very High Very High Very High
long-term potentiation 111 100.00 Very High Very High Very High
Thalamus 91 100.00 Very High Very High Very High
antagonist 72 100.00 Very High Very High Very High
noradrenaline 48 100.00 Very High Very High Very High
nMDA receptor 37 100.00 Very High Very High Very High
GABAergic 11 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Recurrence 23 100.00 Very High Very High Very High
Persistent Fetal Circulation Syndrome 5 100.00 Very High Very High Very High
Stress 590 99.98 Very High Very High Very High
Immunization 90 99.98 Very High Very High Very High
Post-traumatic Stress Disorder 65 99.88 Very High Very High Very High
Sleep Disorders 312 99.72 Very High Very High Very High
Injury 20 99.32 Very High Very High Very High
Heart Rate Under Development 4 98.84 Very High Very High Very High
Anxiety Disorder 664 98.80 Very High Very High Very High
Hypotension 4 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
N-[1(R,S)-Carboxy-3-phenylpropyl]-Ala-Ala-Phe-p-aminobenzoate (cFP-AAF-pAB) is a potent, substrate-related, specific inhibitor of endopeptidase 24.15, an enzyme involved in the metabolism of bioactive peptides including bradykinin, neurotensin, and proenkephalin, and prodynorphin-derived enkephalin precursors.
Negative_regulation (inhibitor) of cFP associated with enkephalin and bradykinin
1) Confidence 0.57 Published 1993 Journal Peptides Section Abstract Doc Link 8134308 Disease Relevance 0.21 Pain Relevance 0.14
Despite reports on involvement of both the mPFC (Salazar et al. 2004, Winstanley et al. 2006) and 5-HT (Beninger and Phillips 1979; SoubriƩ 1986) in impulsive responding and extinction processes, our tests indicate that reduction in mPFC 5-HT does not lead to decreased extinction learning or increased impulsivity.
Negative_regulation (reduction) of mPFC associated with attention deficit hyperactivity disorder
2) Confidence 0.47 Published 2007 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2080349 Disease Relevance 0.17 Pain Relevance 0
It was suggested previously that cFP-AAF-pAB is an inhibitor of angiotensin converting enzyme (ACE) and that this function can account for the hypotensive response to the inhibitor.
Negative_regulation (inhibitor) of cFP associated with hypotension
3) Confidence 0.41 Published 1993 Journal Peptides Section Abstract Doc Link 8134308 Disease Relevance 0.29 Pain Relevance 0.13
Intracisternal administration of cFP-AAF-pAB, an inhibitor of endopeptidase 24.15, prolonged the opioid activity induced by milk infusion.
Negative_regulation (inhibitor) of cFP associated with opioid
4) Confidence 0.41 Published 1994 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 7911578 Disease Relevance 0 Pain Relevance 0.60
These results suggest that mPFC 5-HT depletion induce a specific deficit in goal-directed behaviour that is limited to the ability to use current reward value to guide behaviour (Balleine and Dickinson 1998; Niv et al. 2006).
Negative_regulation (depletion) of mPFC
5) Confidence 0.40 Published 2007 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2080349 Disease Relevance 0.08 Pain Relevance 0
The co-administration of morphine and the D(2) agonist quinpirole (0.5 mg/kg IP) decreased both extracellular DA and NA by 40% in the PFC.
Negative_regulation (decreased) of PFC in PFC
6) Confidence 0.38 Published 2002 Journal Psychopharmacology (Berl.) Section Body Doc Link 11875641 Disease Relevance 0.06 Pain Relevance 0
Lidocaine inactivation of the mPFC prior to the final trial in each task disrupted performance on the temporal order but not the recognition memory task, thereby demonstrating a role for the mPFC in the retrieval and/or use of temporal order information but not in spatial memory per se.
Negative_regulation (inactivation) of mPFC associated with lidocaine
7) Confidence 0.37 Published 2004 Journal Behav. Brain Res. Section Abstract Doc Link 15219729 Disease Relevance 0 Pain Relevance 0.10
The systemic injection (10 mg/kg i.p.) of monoamine oxidase inhibitor, tranylcypromine (TC), significantly elevated 5-HT levels in the striatum, hippocampus and PFC accompanied by a parallel increase in motor activity of the rats.
Negative_regulation (inhibitor) of PFC in PFC associated with hippocampus and monoamine
8) Confidence 0.37 Published 2000 Journal Brain Res. Section Abstract Doc Link 10865074 Disease Relevance 0 Pain Relevance 0.48
In the case of Cesarean section, in addition to the direct administration of morphine to the patient, administration of morphine to the patient's mother just before the delivery is more effective to prevent PFC, which can be easily induced by the initial resuscitation at birth.
Negative_regulation (prevent) of PFC associated with persistent fetal circulation syndrome and morphine
9) Confidence 0.36 Published 1994 Journal Acta Paediatr Jpn Section Abstract Doc Link 7825450 Disease Relevance 0.87 Pain Relevance 0.28
To overcome these problems, we temporarily inactivated the vmPFC of rats with tetrodotoxin (10 ng in a 0.5-microl midline infusion) at one of four time points: prior to conditioning, prior to extinction, immediately after extinction or prior to recall of extinction.
Negative_regulation (inactivated) of vmPFC in midline associated with tetrodotoxin
10) Confidence 0.35 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 17004939 Disease Relevance 0.46 Pain Relevance 0.10
These findings suggest that inactivation of the vmPFC can have opposite effects depending on the phase of training.
Negative_regulation (inactivation) of vmPFC
11) Confidence 0.35 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 17004939 Disease Relevance 0.40 Pain Relevance 0.08
Consistent with lesion findings, inactivation of the vmPFC prior to acquisition had no effect but inactivation prior to extinction led to impaired recall of extinction the following day.
Negative_regulation (inactivation) of vmPFC
12) Confidence 0.35 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 17004939 Disease Relevance 0.44 Pain Relevance 0.09
Effects of mPFC 5-HT depletion on the two-lever discrimination task
Negative_regulation (depletion) of mPFC in lever
13) Confidence 0.35 Published 2007 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2080349 Disease Relevance 0.16 Pain Relevance 0.03
This task was used to assess the effects of mPFC 5-HT depletion on the acquisition of an operant response, discrimination between two spatial stimuli and reversal and extinction of the acquired responses (De Bruin et al. 2000).
Negative_regulation (depletion) of mPFC
14) Confidence 0.35 Published 2007 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2080349 Disease Relevance 0 Pain Relevance 0
Moreover, the same authors (De Wit et al. 2006) showed that inactivation of the mPFC leads to impaired resolving of response conflict through loss of inhibitory function, without any apparent impairment in discriminative function for foods or loss of reinforcing function of food pellets and sugar.
Negative_regulation (inactivation) of mPFC
15) Confidence 0.35 Published 2007 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2080349 Disease Relevance 0 Pain Relevance 0
Conversely, blockade of the tonic inhibitory GABAergic input in the PFC with bicuculline increased the release of dopamine in the medial striatum.
Negative_regulation (blockade) of PFC in medial associated with dopamine and gabaergic
16) Confidence 0.35 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8592128 Disease Relevance 0 Pain Relevance 0.82
At the same delay FC and PAC inactivation weakened only freezing to acoustic CS while PFC inactivation improved the retention of both traces.
Negative_regulation (inactivation) of PFC associated with heart rate under development
17) Confidence 0.35 Published 2002 Journal Exp Brain Res Section Abstract Doc Link 12195524 Disease Relevance 0.57 Pain Relevance 0.22
Infusion of sodium channel blocker tetrodotoxin (1 microM; 90 min) into the LC decreased extracellular noradrenaline in the PFC to approximately 20% of control values.
Negative_regulation (decreased) of PFC in PFC associated with tetrodotoxin, locus ceruleus, noradrenaline and sodium channel
18) Confidence 0.34 Published 1997 Journal Brain Res. Section Abstract Doc Link 9272828 Disease Relevance 0 Pain Relevance 0.93
Infusion of alpha2-adrenoceptor agonist clonidine (100 microM, infused during 15 or 45 min) near to the LC, decreased extracellular noradrenaline in the PFC to 35 and 20% of controls, respectively.
Negative_regulation (decreased) of PFC in PFC associated with locus ceruleus, noradrenaline, agonist and clonidine
19) Confidence 0.34 Published 1997 Journal Brain Res. Section Abstract Doc Link 9272828 Disease Relevance 0 Pain Relevance 1.04
Clonidine and carbachol were similarly effective as in conscious animals but the effects of NMDA and kainate on extracellular noradrenaline in the PFC were clearly suppressed: 145 and 130% of controls, respectively.
Negative_regulation (suppressed) of PFC in PFC associated with noradrenaline and clonidine
20) Confidence 0.34 Published 1997 Journal Brain Res. Section Abstract Doc Link 9272828 Disease Relevance 0 Pain Relevance 1.18

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