INT45375

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Context Info
Confidence 0.85
First Reported 1983
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.56
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprl1) plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
pons 1
medulla 1
Oprl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 9 100.00 Very High Very High Very High
agonist 6 100.00 Very High Very High Very High
mu opioid receptor 4 100.00 Very High Very High Very High
Kappa opioid receptor 1 100.00 Very High Very High Very High
Intracerebroventricular 2 99.76 Very High Very High Very High
medulla 8 98.48 Very High Very High Very High
narcan 3 98.08 Very High Very High Very High
Morphine 1 96.92 Very High Very High Very High
Spinal cord 4 92.88 High High
orphanin 4 92.28 High High
Disease Link Frequency Relevance Heat
Catatonia 2 98.26 Very High Very High Very High
Targeted Disruption 4 94.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Catatonic or hypotonic immobility induced in mice by intracerebroventricular injection of mu or kappa opioid receptor agonists as well as enkephalins or inhibitors of their degradation.
Protein_catabolism (degradation) of kappa opioid receptor associated with agonist, kappa opioid receptor, enkephalin and intracerebroventricular
1) Confidence 0.85 Published 1983 Journal Life Sci. Section Title Doc Link 6685806 Disease Relevance 0.19 Pain Relevance 1.17
These findings suggest that the loss of the PKC gamma gene may protect the functional ORL-1 and mu-opioid receptors from degradation by phosphorylation in the mouse pons/medulla.
Protein_catabolism (degradation) of ORL-1 in medulla associated with medulla and mu opioid receptor
2) Confidence 0.62 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12359310 Disease Relevance 0.18 Pain Relevance 0.77
These findings suggest that the loss of the PKC gamma gene may protect the functional ORL-1 and mu-opioid receptors from degradation by phosphorylation in the mouse pons/medulla.
Protein_catabolism (degradation) of ORL-1 in pons associated with medulla and mu opioid receptor
3) Confidence 0.21 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12359310 Disease Relevance 0.18 Pain Relevance 0.77

General Comments

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