INT45390

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.20
First Reported 1983
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.21
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mip) transmembrane transport (Mip)
Mip (Rattus norvegicus)
Pain Link Frequency Relevance Heat
epidural 3 94.96 High High
analgesia 4 94.24 High High
sodium channel 2 92.64 High High
Morphine 3 90.24 High High
lidocaine 1 89.36 High High
Kinase C 2 81.32 Quite High
Analgesic 1 79.92 Quite High
Neuronal excitability 2 76.12 Quite High
Dopamine 2 70.68 Quite High
gABA 4 67.80 Quite High
Disease Link Frequency Relevance Heat
Manic Depressive Disorder 74 57.00 Quite High
Epilepsy 2 56.16 Quite High
Anxiety Disorder 4 47.04 Quite Low
Drug Dependence 6 46.16 Quite Low
Suicidal Behaviour 2 40.92 Quite Low
Depression 14 38.20 Quite Low
Vomiting 4 18.80 Low Low
Depressive Disorder 2 17.68 Low Low
Asthenia 2 17.68 Low Low
Dyspepsia 2 14.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VC, FEV1, MEP and MIP markedly decreased following laparotomy.
Negative_regulation (decreased) of MIP
1) Confidence 0.20 Published 1983 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 6687651 Disease Relevance 0 Pain Relevance 0.92
Another proposed mechanism, though controversial, is one likening valproate to lithium as a potential inhibitor of inositol synthesis through inhibition of myo-inositol-1phosphate (MIP) (Harwood and Agam 2003; Shaltiel et al 2004; Harwood 2005).
Negative_regulation (inhibition) of MIP
2) Confidence 0.02 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656326 Disease Relevance 0.11 Pain Relevance 0.26
It is not well understood if valproate inhibits MIP directly, but it has been shown to deplete inositol (Harwood and Agam 2003; Shaltiel et al 2004; Harwood 2005).


Negative_regulation (inhibits) of MIP
3) Confidence 0.02 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656326 Disease Relevance 0.10 Pain Relevance 0.24

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox