INT45415

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Context Info
Confidence 0.44
First Reported 1984
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 3.10
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Urine 2
spinal cord 1
brain 1
bands 1
G4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 10 100.00 Very High Very High Very High
tetrodotoxin 4 98.56 Very High Very High Very High
anesthesia 8 95.32 Very High Very High Very High
imagery 88 84.16 Quite High
cerebral cortex 32 72.32 Quite High
transdermal 23 50.00 Quite Low
diclofenac 4 50.00 Quite Low
cINOD 3 50.00 Quite Low
cOX1 4 10.00 Low Low
COX2 4 10.00 Low Low
Disease Link Frequency Relevance Heat
Spinal Cord Injury 10 100.00 Very High Very High Very High
Aneurism 2 99.40 Very High Very High Very High
Arrhythmias 2 Under Development 3 97.84 Very High Very High Very High
Cancer 105 92.72 High High
Pathologic Processes 4 92.60 High High
Injury 8 92.08 High High
Glioma 140 86.92 High High
Cirrhosis 76 80.36 Quite High
Disorders Of Creatine Metabolism 2 69.80 Quite High
Brain Tumor 48 67.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Malonyldialdehyde values were significantly increased in G2 compared to G1, G3 and G4 (p<0.05).
Positive_regulation (increased) of G4
1) Confidence 0.44 Published 2010 Journal J Clin Neurosci Section Abstract Doc Link 20116256 Disease Relevance 0.59 Pain Relevance 0.30
For the rats in the G2, G3, and G4 groups, spinal cord injury was induced by placing an aneurysm clip extradurally for 60 s at T10.
Positive_regulation (induced) of G4 in spinal cord associated with aneurism and spinal cord
2) Confidence 0.44 Published 2010 Journal J Clin Neurosci Section Abstract Doc Link 20116256 Disease Relevance 0.62 Pain Relevance 0.25
It is thus not possible to correlate increased G4 activity with altered immunoreactivity.
Spec (possible) Positive_regulation (increased) of G4
3) Confidence 0.43 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.11 Pain Relevance 0
Urine volume in G2 increased significantly compared with G1, G3, and G4.
Positive_regulation (increased) of G4 in Urine
4) Confidence 0.41 Published 2009 Journal Int Urol Nephrol Section Body Doc Link 19031110 Disease Relevance 0.07 Pain Relevance 0
Urine Na in G2 increased significantly compared with G4.
Positive_regulation (increased) of G4 in Urine
5) Confidence 0.41 Published 2009 Journal Int Urol Nephrol Section Body Doc Link 19031110 Disease Relevance 0.06 Pain Relevance 0
They established that the higher permeability of G4 is due to higher interaction with cell surface.
Positive_regulation (permeability) of G4
6) Confidence 0.30 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792561 Disease Relevance 0 Pain Relevance 0
In an attempt to assign immunopositive AChE bands to specific AChE species, immunoblots were performed for the G4 and G1 + G2 peaks from sucrose density gradients (Fig. 5C).
Positive_regulation (performed) of G4 in bands
7) Confidence 0.27 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0 Pain Relevance 0.03
There was no correlation between increased G4 cortical AChE activity in BDL with immunoreactivity as much of the AChE immunoreactivity was associated with unaltered protein that was present in the G1 + G2 peak and may correspond to both active and inactive subunits (García-Ayllón et al., 2007).
Positive_regulation (increased) of G4
8) Confidence 0.27 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0 Pain Relevance 0.07
The BDL-induced increase in G4, which is the major AChE form in the brain, was not accompanied by a change in its T-transcript.
Positive_regulation (increase) of G4 in brain
9) Confidence 0.27 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.22 Pain Relevance 0
When fibrillation is prevented by adding tetrodotoxin on day 4, the increases in the A12 and A8 forms are prevented, and the increases in the G4 and G1 forms are significantly impaired.
Positive_regulation (increases) of G4 associated with tetrodotoxin and arrhythmias 2 under development
10) Confidence 0.27 Published 1984 Journal J. Neurosci. Section Abstract Doc Link 6693937 Disease Relevance 0.18 Pain Relevance 0.33
The polydispersibility indices also showed the similar patterns of dispersibilities ie, formulation G4 had the least value and G1 had the maximum.
Positive_regulation (formulation) of G4
11) Confidence 0.06 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2636584 Disease Relevance 0 Pain Relevance 0
One was a lowly conjugated Gd-G4 weighing 24.4 kD and the other was a standard Gd-G4 weighing 39.8 kD.
Positive_regulation (conjugated) of Gd-G4
12) Confidence 0.02 Published 2008 Journal J Transl Med Section Body Doc Link PMC2639552 Disease Relevance 0.63 Pain Relevance 0.18
One was a lowly conjugated Gd-G4 weighing 24.4 kD and the other was a standard Gd-G4 weighing 39.8 kD.
Positive_regulation (conjugated) of Gd-G4
13) Confidence 0.02 Published 2008 Journal J Transl Med Section Body Doc Link PMC2639552 Disease Relevance 0.62 Pain Relevance 0.15

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