INT45427

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Context Info
Confidence 0.49
First Reported 1984
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 20
Total Number 23
Disease Relevance 11.89
Pain Relevance 4.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cacna2d2)
Anatomy Link Frequency
M cell 2
plasma 1
heart 1
Cacna2d2 (Mus musculus)
Pain Link Frequency Relevance Heat
methadone 71 99.98 Very High Very High Very High
Calcium channel 2 97.68 Very High Very High Very High
anesthesia 28 96.68 Very High Very High Very High
halothane 19 96.46 Very High Very High Very High
lidocaine 1 96.16 Very High Very High Very High
potassium channel 8 94.88 High High
sSRI 3 93.92 High High
drug abuse 11 90.96 High High
cocaine 16 89.20 High High
Action potential 6 85.52 High High
Disease Link Frequency Relevance Heat
Arrhythmia Under Development 161 100.00 Very High Very High Very High
Heart Rate Under Development 32 99.80 Very High Very High Very High
Cv Unclassified Under Development 16 99.72 Very High Very High Very High
Arrhythmias 2 Under Development 1 99.04 Very High Very High Very High
Death 3 98.44 Very High Very High Very High
Cv General 2 Under Development 12 98.40 Very High Very High Very High
Syndrome 26 97.12 Very High Very High Very High
Overdose 1 95.96 Very High Very High Very High
Cardiovascular Disease 1 92.88 High High
Drug Dependence 9 90.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The underlying mutation was mapped to chromosome 9 (60.1 centimorgans) and identified as an allele of the Cacna2d2 gene encoding the alpha2delta-2 subunit of voltage-gated calcium channels.
Positive_regulation (allele) of Cacna2d2 associated with calcium channel
1) Confidence 0.49 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14660671 Disease Relevance 0.18 Pain Relevance 0.05
Most patients that develop drug-induced TdP have underlying risk factors.
Positive_regulation (induced) of TdP associated with arrhythmia under development
2) Confidence 0.45 Published 2007 Journal Am. Heart J. Section Abstract Doc Link 17540188 Disease Relevance 0.60 Pain Relevance 0.08
In 1 patient, TdP was induced by a combination of quinidine and amiodarone, in the second by procainamide, and in the third by an overdose of imipramine.
Positive_regulation (induced) of TdP associated with arrhythmia under development and overdose
3) Confidence 0.30 Published 1984 Journal Am. J. Cardiol. Section Abstract Doc Link 6695782 Disease Relevance 0.94 Pain Relevance 0.05
Female gender, interacting medications, hypokalemia, hypomagnesemia, and structural heart disease, risk factors previously identified with other drugs known to cause TdP, were found in 44 (75%) cases.
Positive_regulation (cause) of TdP in heart
4) Confidence 0.30 Published 2005 Journal Pharmacoepidemiol Drug Saf Section Body Doc Link 15918160 Disease Relevance 0.11 Pain Relevance 0
Predicting an individual's propensity for methadone-induced TdP is difficult at present given the inherent limitations of the QT interval as a risk-stratifier combined with the multifactorial nature of the arrhythmia.
Positive_regulation (induced) of TdP associated with arrhythmia under development and methadone
5) Confidence 0.30 Published 2009 Journal Cardiology journal Section Abstract Doc Link 19437394 Disease Relevance 0.76 Pain Relevance 1.17
RESULTS: The most prevalent risk factors for TdP were high-dose methadone (n = 39, 97.5%) and concomitant use of agents that increase serum methadone levels or trigger TdP (n = 22, 55%).
Positive_regulation (increase) of TdP
6) Confidence 0.26 Published 2006 Journal Addiction Section Body Doc Link 16911733 Disease Relevance 0 Pain Relevance 0
Temporary pacing could not be performed, because insertion of a pacing lead triggered TdP that deteriorated into ventricular fibrillation.
Positive_regulation (triggered) of TdP associated with arrhythmias 2 under development
7) Confidence 0.26 Published 1999 Journal Pacing Clin Electrophysiol Section Abstract Doc Link 10234727 Disease Relevance 0.25 Pain Relevance 0.22
At 1 mg/kg, however, TdP were induced in 5 of 10 animals and in an additional 2 animals at 3 mg/kg.
Positive_regulation (induced) of TdP associated with arrhythmia under development
8) Confidence 0.22 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11222883 Disease Relevance 1.05 Pain Relevance 0.56
Single and multiple ectopic beats preceded the induction of TdP, and the ectopic beats were observed in a dose-dependent manner.
Positive_regulation (induction) of TdP associated with cv unclassified under development and arrhythmia under development
9) Confidence 0.22 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11222883 Disease Relevance 1.07 Pain Relevance 0.56
A wide variety of nonantiarrthymic medications may trigger TdP in patients with prolonged QT interval, only a few reports have described an association between TdP and methadone.
Spec (may) Positive_regulation (trigger) of TdP associated with arrhythmia under development and methadone
10) Confidence 0.21 Published 2004 Journal W V Med J Section Abstract Doc Link 15471174 Disease Relevance 0.64 Pain Relevance 0.26
To investigate its short-term, antiarrhythmic properties, Dron was given after almokalant (0.12 mg/kg)-induced TdP.
Positive_regulation (induced) of TdP associated with arrhythmia under development
11) Confidence 0.17 Published 1999 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 10028928 Disease Relevance 0.79 Pain Relevance 0.04
In halothane-anesthetized dogs, a remarkable transient increase in M cell MAPD followed interpolation of one or more extrasystole(s), leading to a transient increase in TDR and TdP.
Positive_regulation (increase) of TdP in M cell
12) Confidence 0.14 Published 2000 Journal J. Cardiovasc. Electrophysiol. Section Body Doc Link 10749352 Disease Relevance 0.07 Pain Relevance 0
In conclusion, this acute canine model of TdP with halothane anesthesia, complete AV block, PES, and simultaneous measurements of plasma drug concentration would be valuable for assessing the risk of drugs, especially I(Kr) blockers, to induce TdP in humans.
Positive_regulation (induce) of TdP in plasma associated with anesthesia, arrhythmia under development and halothane
13) Confidence 0.13 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11222883 Disease Relevance 0.89 Pain Relevance 0.50
Almokalant-induced TdP was characterized by an increased repolarization duration, deltaAPD, and EADs.
Positive_regulation (induced) of TdP associated with arrhythmia under development
14) Confidence 0.12 Published 1999 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 10028928 Disease Relevance 0.82 Pain Relevance 0.03
There are no reported cases of lithium induced TdP.
Neg (no) Positive_regulation (induced) of TdP
15) Confidence 0.05 Published 2010 Journal Curr Drug Saf Section Abstract Doc Link 20210726 Disease Relevance 0.66 Pain Relevance 0.30
While awaiting admission, the patient experienced several episodes of TdP and ventricular tachycardia.
Positive_regulation (experienced) of TdP associated with heart rate under development and arrhythmia under development
16) Confidence 0.05 Published 2008 Journal Int J Emerg Med Section Body Doc Link PMC2657284 Disease Relevance 1.01 Pain Relevance 0
As a result, a black box warning for methadone was issued in 2006 by the US Food and Drug Administration, alerting practitioners to the increased risk of TdP particularly in patients with drug interactions.
Positive_regulation (increased) of TdP associated with arrhythmia under development and methadone
17) Confidence 0.04 Published 2008 Journal Int J Emerg Med Section Body Doc Link PMC2657284 Disease Relevance 1.31 Pain Relevance 0.89
CONCLUSIONS: Thiopental anesthesia causes arrhythmias sec, whereas anesthesia in general predisposes for drug-induced TdP in the CAVB dog.
Positive_regulation (induced) of TdP
18) Confidence 0.01 Published 2010 Journal J. Cardiovasc. Pharmacol. Section Body Doc Link 20555233 Disease Relevance 0 Pain Relevance 0
RESULTS: Part 1-In paced dogs, dofetilide-induced TdP was higher under anesthetized than in conscious circumstances, with the more severe outcome seen after T + I as compared with P + H or control (2x): 5/5, 2/5, 0/5, and 0/5, respectively; P < 0.05.
Positive_regulation (induced) of TdP
19) Confidence 0.01 Published 2010 Journal J. Cardiovasc. Pharmacol. Section Body Doc Link 20555233 Disease Relevance 0 Pain Relevance 0
The high dose of sematilide induced TdP in 3 of 4 animals, which caused their death, but neither the low dose of sematilide nor the 2 dosages of amiodarone induced lethal ventricular arrhythmias.
Positive_regulation (induced) of TdP associated with arrhythmia under development and death
20) Confidence 0.00 Published 2002 Journal Circ. J. Section Abstract Doc Link 12197602 Disease Relevance 0.43 Pain Relevance 0.13

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