INT45448

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Context Info
Confidence 0.03
First Reported 1984
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 1.94
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 2
dendrites 1
colon 1
whiskers 1
Vom1r68 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 4 97.28 Very High Very High Very High
Rostral ventrolateral medulla 3 96.24 Very High Very High Very High
Morphine 6 90.16 High High
withdrawal 3 89.44 High High
nMDA receptor 165 88.40 High High
Visceral pain 40 86.48 High High
Dismenorea 1 83.76 Quite High
nud 50 83.52 Quite High
Inflammation 145 80.60 Quite High
Spinal cord 30 71.20 Quite High
Disease Link Frequency Relevance Heat
Aids-related Complex 8 99.78 Very High Very High Very High
Colitis 115 96.60 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

40 86.48 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

45 85.20 High High
Dysmenorrhea 1 83.76 Quite High
Dyspepsia 50 83.52 Quite High
Injury 40 80.88 Quite High
INFLAMMATION 145 80.60 Quite High
Shoulder Pain 1 48.88 Quite Low
Headache 1 48.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the levels of C1 as well as those of C2 and C3 were markedly increased in the peripheral serum of day-21 rats within 15 min of LH administration.
Gene_expression (levels) of C1
1) Confidence 0.03 Published 1984 Journal Endocrinology Section Abstract Doc Link 6697963 Disease Relevance 0.08 Pain Relevance 0.08
In the C1-2 and C3-4 subgroups, labeled neurons were present from C1 to C8 DRGs, while in C5-6 subgroups they were from C3 to C8.
Gene_expression (present) of C1 in neurons
2) Confidence 0.03 Published 2006 Journal Chin. J. Traumatol. Section Body Doc Link 17096935 Disease Relevance 0 Pain Relevance 0
Many of these neurons express the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT), and are designated C1 neurons.
Gene_expression (express) of C1 in neurons
3) Confidence 0.03 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 16194531 Disease Relevance 0 Pain Relevance 0.61
Our immunocytochemistry revealed that the NR1-C1 protein was expressed on dendrites in the myenteric plexus (see arrow in Fig 4B) following TNBS treatment.
Gene_expression (expressed) of C1 in dendrites
4) Confidence 0.01 Published 2006 Journal Mol Pain Section Body Doc Link PMC1402265 Disease Relevance 0.29 Pain Relevance 0.24
The NR1-C1 was not expressed in the sub-mucosa.
Neg (not) Gene_expression (expressed) of C1
5) Confidence 0.01 Published 2006 Journal Mol Pain Section Body Doc Link PMC1402265 Disease Relevance 0.22 Pain Relevance 0.22
Double-labeling fluorescent immunocytochemistry showed that the NR1-C1 and NR1-N1 are not expressed in the untreated control rat's colon (Fig. 4A and 4B).
Neg (not) Gene_expression (expressed) of C1 in colon
6) Confidence 0.01 Published 2006 Journal Mol Pain Section Body Doc Link PMC1402265 Disease Relevance 0.21 Pain Relevance 0.03
In addition, NR1-N1 and NR1-C1 protein expression was also present in the colonic myenteric plexus in TNBS treated rats.
Gene_expression (expression) of C1
7) Confidence 0.01 Published 2006 Journal Mol Pain Section Body Doc Link PMC1402265 Disease Relevance 0.55 Pain Relevance 0.31
This was true for both arc 1 (D1 and C1) whiskers, and arc 2 (D2 and C2) whiskers.
Gene_expression (whiskers) of C1 in whiskers associated with aids-related complex
8) Confidence 0.01 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2525689 Disease Relevance 0.33 Pain Relevance 0
The NR1-C1 and NR1-N1 were probed by using Alex fluor 594 (Molecular Probes, Inc.) with Texas Red broadband filter (Zeiss Oberkochen, Germany).
Gene_expression (probed) of C1
9) Confidence 0.00 Published 2006 Journal Mol Pain Section Body Doc Link PMC1402265 Disease Relevance 0 Pain Relevance 0

General Comments

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