INT4554

Context Info Confidence 0.35 First Reported 1975 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 5 Total Number 6 Disease Relevance 2.04 Pain Relevance 3.50

extracellular region (Otor) Golgi apparatus (Otor)

Anatomy Link Frequency tendon 1 finger 1 Otor (Mus musculus)

Pain Link Frequency Relevance Heat antinociception 14 100.00 antagonist 6 99.00 agonist 16 98.68 Pain 6 98.08 Paresthesia 6 93.24 Antinociceptive 6 86.80 carpal tunnel syndrome 4 85.20 Morphine 18 83.04 imagery 12 81.84 tail-flick 4 75.00

Disease Link Frequency Relevance Heat Cancer 12 98.44 Frailty 10 98.32 Hamartoma 34 93.28 Dysesthesia 4 93.24 Carpal Tunnel Syndrome 8 91.36 Disease 4 89.60 Nerve Cancer 22 75.32 Thrombophilia 1 75.00 Trigger Finger Disorder 2 69.20 Anaemia 1 64.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Under the present conditions, agonists and antagonists at adrenergic and dopaminergic receptors did not attenuate MIA.

Neg (not) Negative_regulation (attenuate) of MIA associated with antinociception, antagonist and agonist

1) Confidence 0.35 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1672380 Disease Relevance 0 Pain Relevance 1.43

The putative selective 5-HT1A antagonists, BMY 7378 [(8-[-[4-(2-,ethoxyphenyl)-1-piperazinyl]ethyl]-8-azaspirol[4]- decane-7,9-dione-2-HCL] and spiperone, did not reduce MIA.

Neg (not) Negative_regulation (reduce) of MIA associated with antinociception and antagonist

2) Confidence 0.35 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1672380 Disease Relevance 0 Pain Relevance 1.65

We will follow our patient regarding any progression of the tumour and further consider additional treatment, such as tendon transfers, for the impaired function of FPL and FDP to the index finger.

Negative_regulation (impaired) of FDP in tendon associated with cancer

3) Confidence 0.05 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2823742 Disease Relevance 0.57 Pain Relevance 0.04

Furthermore, she told about fibrillations in the interphalangeal joint of the right thumb and the index finger, loss of FPL and FDP function to the index finger followed by atrophy of the thenar muscles a year later.

Negative_regulation (loss) of FDP in finger associated with frailty

4) Confidence 0.05 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2823742 Disease Relevance 0.96 Pain Relevance 0.20

Two patients on painful crises with complications had additional abnormal findings, namely prolonged prothrombin time, reduced At-III level and elevated FDP.

Negative_regulation (reduced) of FDP associated with pain

5) Confidence 0.04 Published 1975 Journal Blut Section Abstract Doc Link 1203541 Disease Relevance 0.50 Pain Relevance 0.19

Postoperatively, the FDP concentration was reduced and ELT prolonged.

Negative_regulation (reduced) of FDP

6) Confidence 0.03 Published 2001 Journal Eur J Ophthalmol Section Body Doc Link 11284489 Disease Relevance 0 Pain Relevance 0

General Comments

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