INT4555

Context Info Confidence 0.31 First Reported 1975 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 6 Total Number 9 Disease Relevance 8.79 Pain Relevance 1.29

extracellular region (Otor) Golgi apparatus (Otor)

Anatomy Link Frequency Blood 3 plasma 1 endothelial cell 1 Otor (Mus musculus)

Pain Link Frequency Relevance Heat Pain 6 97.58 cva 20 90.84 abdominal pain 5 90.04 headache 1 75.40 Arthritis 1 68.24 anesthesia 4 5.00

Disease Link Frequency Relevance Heat Thrombocytopenia 1 99.96 Chronic Subdural Hematoma 172 99.84 Head Trauma 36 98.08 Nose Bleeds 1 96.48 Hypoalbuminemia 1 95.96 Hemorrhage 47 95.56 Hematoma 148 94.20 Leukocytosis 1 93.52 Coagulation Disorder 88 92.96 Aneurism 3 92.20

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Blood chemistry showed transient elevation of CRP, serum LDH, FDP, FDP-Ddimer and fibrinogen.

Positive_regulation (elevation) of FDP in Blood

1) Confidence 0.31 Published 1991 Journal Rinsho Ketsueki Section Abstract Doc Link 1942546 Disease Relevance 0.91 Pain Relevance 0.35

Blood chemistry showed transient elevation of CRP, serum LDH, FDP, FDP-Ddimer and fibrinogen.

Positive_regulation (elevation) of FDP-Ddimer in Blood

2) Confidence 0.31 Published 1991 Journal Rinsho Ketsueki Section Abstract Doc Link 1942546 Disease Relevance 0.92 Pain Relevance 0.35

Laboratory examination revealed thrombocytopenia, increase of FDP and prolongation of prothrombin time.

Positive_regulation (increase) of FDP associated with thrombocytopenia

3) Confidence 0.19 Published 1983 Journal No Shinkei Geka Section Abstract Doc Link 6621789 Disease Relevance 1.68 Pain Relevance 0.19

Accumulation of blood, fibrin, and FDP within the subdural space may lead to either cellular organization with resorption of the subdural collection or to the development of a gradually enlarging SDH.

Positive_regulation (Accumulation) of FDP in blood

4) Confidence 0.10 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628130 Disease Relevance 0.47 Pain Relevance 0

Elevated FDP in chronic subdural hematoma suggested enhanced fibrinolytic activity, which could be associated with further bleeding.

Positive_regulation (Elevated) of FDP associated with chronic subdural hematoma and hemorrhage

5) Confidence 0.10 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628130 Disease Relevance 1.15 Pain Relevance 0.04

In our study, the FDP levels markedly increased in the chronic subdural hematoma when compared to the levels in patients' plasma.

Positive_regulation (increased) of FDP in plasma associated with chronic subdural hematoma

6) Confidence 0.07 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628130 Disease Relevance 1.16 Pain Relevance 0.04

If the FDP concentrations in the CSDH and ASDH fluids were measured by a quantitative method, such as hemagglutination-inhibition immunoassay technique, the gradual increase of FDP levels will be shown as an indicator for a switch from being an ASDH to a CSDH, because fibrinolysis takes place in subdural hematoma continuously.

Positive_regulation (increase) of FDP associated with head trauma and chronic subdural hematoma

7) Confidence 0.07 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628130 Disease Relevance 1.12 Pain Relevance 0

Two patients on painful crises with complications had additional abnormal findings, namely prolonged prothrombin time, reduced At-III level and elevated FDP.

Positive_regulation (elevated) of FDP associated with pain

8) Confidence 0.05 Published 1975 Journal Blut Section Abstract Doc Link 1203541 Disease Relevance 0.50 Pain Relevance 0.19

Although prothrombin time and activated partial thromboplastin time were within normal limits, the increased levels of FDP-E, D-dimer, and von Willebrand factor activity were observed, which suggested the endothelial cell activation and the coagulation/fibrinolysis system activation.

Positive_regulation (increased) of FDP-E in endothelial cell

9) Confidence 0.01 Published 2000 Journal Nihon Rinsho Meneki Gakkai Kaishi Section Abstract Doc Link 10863331 Disease Relevance 0.88 Pain Relevance 0.12

General Comments

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