INT45553

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Context Info
Confidence 0.43
First Reported 1984
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.73
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PCK1) lyase activity (PCK1) carbohydrate metabolic process (PCK1)
lipid metabolic process (PCK1) cytoplasm (PCK1) cytosol (PCK1)
Anatomy Link Frequency
liver 1
PCK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tramadol 11 99.98 Very High Very High Very High
Opioid 3 93.20 High High
narcan 4 87.84 High High
Bioavailability 9 42.96 Quite Low
anesthesia 1 25.00 Low Low
antagonist 37 21.88 Low Low
agonist 9 19.84 Low Low
Inflammation 11 5.00 Very Low Very Low Very Low
local anesthetic 11 5.00 Very Low Very Low Very Low
Angina 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 15 98.84 Very High Very High Very High
Thyroid Neoplasm 1 64.24 Quite High
Breast Cancer 17 56.56 Quite High
Colorectal Cancer 1 48.08 Quite Low
Liposarcoma 2 46.48 Quite Low
Cancer 131 39.00 Quite Low
Apoptosis 36 22.92 Low Low
Heart Rate Under Development 18 5.00 Very Low Very Low Very Low
Disease 18 5.00 Very Low Very Low Very Low
INFLAMMATION 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of rats with 3-mercaptopicolinic acid, a potent inhibitor of phosphoenol-pyruvate carboxykinase, prior to [1-14C]glucose infusion reduced hepatic glycogen synthesis by 85%; this glycogen contained most of its label in C-1 of glucose.
Negative_regulation (inhibitor) of carboxykinase
1) Confidence 0.43 Published 1984 Journal J. Biol. Chem. Section Abstract Doc Link 6725277 Disease Relevance 0 Pain Relevance 0
Moreover, similar repeated treatments with tramadol reversed the elevated mRNA and protein levels of phosphoenolpyruvate carboxykinase in the liver of STZ-induced diabetic rats.
Negative_regulation (reversed) of carboxykinase in liver associated with tramadol and diabetes mellitus
2) Confidence 0.07 Published 2001 Journal Diabetes Section Abstract Doc Link 11723065 Disease Relevance 0.54 Pain Relevance 1.17
Decreased hepatic gluconeogenesis can occur by hepatic lactate uptake inhibition [252], although other studies have found that metformin decreases gluconeogenic flux through pyruvate carboxylase inhibition, phosphoenolpyruvate carboxykinase activity, and, possibly through increased conversion of pyruvate to alanine [253].
Spec (possibly) Negative_regulation (inhibition) of carboxykinase
3) Confidence 0.01 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.19 Pain Relevance 0

General Comments

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