INT45564

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Context Info
Confidence 0.49
First Reported 1984
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.85
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (Gpt) cellular_component (Gpt) biological_process (Gpt)
cytoplasm (Gpt)
Gpt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 9 100.00 Very High Very High Very High
Paracetamol 11 96.28 Very High Very High Very High
adenocard 1 92.08 High High
opioid receptor 4 76.16 Quite High
Inflammation 2 74.60 Quite High
antagonist 2 72.56 Quite High
Opioid 2 72.12 Quite High
Clonidine 1 52.84 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 1 99.12 Very High Very High Very High
Increased Venous Pressure Under Development 2 95.92 Very High Very High Very High
Necrosis 1 91.32 High High
Heart Rate Under Development 2 88.96 High High
Pressure Volume 2 Under Development 2 88.32 High High
Poisoning 1 82.08 Quite High
Sepsis 8 80.88 Quite High
Hepatotoxicity 5 75.00 Quite High
INFLAMMATION 2 74.60 Quite High
Chronic Renal Failure 1 74.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Much greater changes were found in the kidneys, with increased activity of glucose-6-phosphate dehydrogenase and decreased activities of aspartate and alanine aminotransferases, alkaline phosphatase, malic dehydrogenase, sorbitol dehydrogenase and gamma-glutamyltransferase, as well as a decreased phosphorylation to oxidation ratio in the mitochondria, indicating reduced adenosine triphosphate production.
Positive_regulation (increased) of Positive_regulation (activity) of alanine aminotransferase associated with adenocard
1) Confidence 0.49 Published 1994 Journal Eur J Clin Chem Clin Biochem Section Abstract Doc Link 7888481 Disease Relevance 0.13 Pain Relevance 0.10
Hepatocytolysis was determined by measuring the level of serum transaminases (GPT and GOT), steatosis by Sudan black staining, histological structures by hamatoxylineosin staining and the activity of enzymes such as SDH, GtDH, G-6-Pase and ATPase.
Spec (determined) Positive_regulation (measuring) of Positive_regulation (level) of GPT
2) Confidence 0.49 Published 1999 Journal Phytother Res Section Abstract Doc Link 10190184 Disease Relevance 0.08 Pain Relevance 0.17
A toxic dose of the drug ( LD20 ) produced elevated serum glutamate-pyruvate transaminase and lactate dehydrogenase activities 20-24 hr after drug administration only in 19- and 33-day-old animals.
Positive_regulation (produced) of Positive_regulation (elevated) of serum glutamate-pyruvate transaminase associated with glutamate
3) Confidence 0.40 Published 1984 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 6729816 Disease Relevance 0.17 Pain Relevance 0.52
Daily intubation of wistar strain albino rat's with 100 mg/mL/day for 7 days caused a significant increase (p<0.05) in serum alkaline phosphatase (ALP), Glutamate Oxaloacetate Transaminase (GOT) and Glutamate Pyruvate Transaminase (GPT), while there was no significant change (p>0.05) in serum bilirubin, albumin, globulin and total proteins in the rats.
Positive_regulation (caused) of Positive_regulation (increase) of GPT associated with glutamate and sprains and strains
4) Confidence 0.39 Published 2007 Journal Pak. J. Biol. Sci. Section Abstract Doc Link 19070082 Disease Relevance 0.30 Pain Relevance 0.40
Naltrexone significantly reduced the elevation of serum glutamate-oxalacetate transaminase and glutamate-pyruvate transaminase (as index of hepatic function) induced by LPS.
Positive_regulation (induced) of Positive_regulation (elevation) of glutamate-pyruvate transaminase associated with glutamate
5) Confidence 0.24 Published 2005 Journal J. Biomed. Sci. Section Abstract Doc Link 15917999 Disease Relevance 0.58 Pain Relevance 0.28
Naltrexone significantly reduced the elevation of serum glutamate-oxalacetate transaminase and glutamate-pyruvate transaminase (as index of hepatic function) induced by LPS.
Positive_regulation (elevation) of Positive_regulation (induced) of glutamate-pyruvate transaminase associated with glutamate
6) Confidence 0.24 Published 2005 Journal J. Biomed. Sci. Section Abstract Doc Link 15917999 Disease Relevance 0.58 Pain Relevance 0.28

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