INT45565

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Context Info
Confidence 0.39
First Reported 1984
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 1.54
Pain Relevance 2.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ldha) mitochondrion (Ldha) oxidoreductase activity (Ldha)
cytoplasm (Ldha)
Anatomy Link Frequency
hepatocytes 2
Ldha (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 11 100.00 Very High Very High Very High
Glutamate 6 100.00 Very High Very High Very High
gABA 5 99.60 Very High Very High Very High
Paracetamol 21 99.48 Very High Very High Very High
tetrodotoxin 2 95.32 Very High Very High Very High
Inflammation 86 94.12 High High
Neurotransmitter 1 91.84 High High
adenocard 4 88.84 High High
antagonist 2 78.40 Quite High
Calcium channel 1 77.96 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 8 100.00 Very High Very High Very High
Acute Liver Failure 31 96.76 Very High Very High Very High
Pneumonia 16 94.12 High High
Necrosis 9 91.32 High High
Injury 41 81.72 Quite High
Hepatitis Virus Infection 3 81.08 Quite High
Cirrhosis 18 75.76 Quite High
Hepatotoxicity 16 75.00 Quite High
Acute Renal Failure 1 70.12 Quite High
Cv General 4 Under Development 1 59.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A toxic dose of the drug ( LD20 ) produced elevated serum glutamate-pyruvate transaminase and lactate dehydrogenase activities 20-24 hr after drug administration only in 19- and 33-day-old animals.
Positive_regulation (produced) of Positive_regulation (elevated) of lactate dehydrogenase associated with glutamate
1) Confidence 0.39 Published 1984 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 6729816 Disease Relevance 0.17 Pain Relevance 0.53
Increases in LDH levels in the extracellular fluid became apparent during the period of ischemia and continued to increase during the subsequent 90 min of reperfusion.
Positive_regulation (increase) of Positive_regulation (Increases) of LDH associated with ischemia
2) Confidence 0.38 Published 1994 Journal Brain Res. Bull. Section Abstract Doc Link 7915962 Disease Relevance 0.37 Pain Relevance 1.13
CCl4 injection resulted in a significant increase in hepatic levels of LDH-2, LDH-3 and LDH-5; however, it significantly decreased hepatic LDH-4.
Positive_regulation (resulted) of Positive_regulation (increase) of LDH-5
3) Confidence 0.38 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.08 Pain Relevance 0
Mitcheva et al. [31] reported that CCl4 injection leads to a significant increase in LDH leakage from rat hepatocytes.
Positive_regulation (leads) of Positive_regulation (increase) of LDH in hepatocytes
4) Confidence 0.38 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.16 Pain Relevance 0
Incubation with APAP 0.1, 1 and 10 mM did not promote an increment in LDH release compared with controls, while APAP 100 mM promoted an increased LDH release.
Neg (not) Positive_regulation (promote) of Positive_regulation (increment) of LDH associated with paracetamol
5) Confidence 0.34 Published 2005 Journal Biochim. Biophys. Acta Section Abstract Doc Link 15949700 Disease Relevance 0.07 Pain Relevance 0.99
Our data are in harmony with Wills and Asha [10] who reported that CCl4 administration in rats caused elevation of serum LDH activity.
Positive_regulation (caused) of Positive_regulation (elevation) of LDH
6) Confidence 0.33 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.30 Pain Relevance 0.03
RESULTS: Corocalm (48.5 mg/kg and 194.0 mg/kg) significantly decreased the degree and scope of myocardial ischemia, reduced the infarct area, markedly increased the CBF, and inhibited the increase of CK and LDH activities and ET levels induced by myocardial ischemia/infarction.
Positive_regulation (increase) of Positive_regulation (induced) of LDH
7) Confidence 0.17 Published 2007 Journal Chin J Integr Med Section Body Doc Link 17898952 Disease Relevance 0.05 Pain Relevance 0
Although the simple ALT/LDH ratio seems to be acceptable in evaluation of the serum activity of LDH connecting to ALT, it could not reflect the degree of those enzymes' elevation from normal level when they are in relatively low levels because of the difference of their normal ranges.
Positive_regulation (acceptable) of Positive_regulation (simple) of LDH
8) Confidence 0.10 Published 2008 Journal Comp Hepatol Section Body Doc Link PMC2527551 Disease Relevance 0.18 Pain Relevance 0
At all time points and in a dose-dependent manner, silica induced a significant increase in BALF LDH and protein levels in rats (Figure 1 A &1 B).
Positive_regulation (induced) of Positive_regulation (increase) of BALF LDH
9) Confidence 0.06 Published 2005 Journal Respir Res Section Body Doc Link PMC1274346 Disease Relevance 0.18 Pain Relevance 0.09

General Comments

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