INT4557

Context Info Confidence 0.11 First Reported 1975 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 7 Disease Relevance 5.85 Pain Relevance 0.41

extracellular region (Otor) Golgi apparatus (Otor)

Anatomy Link Frequency plasma 1 endothelial cell 1 Otor (Mus musculus)

Pain Link Frequency Relevance Heat Pain 2 97.44 abdominal pain 1 89.64 anesthesia 6 70.84 Arthritis 1 68.24 cva 16 50.64

Disease Link Frequency Relevance Heat Chronic Subdural Hematoma 172 99.76 Head Trauma 32 99.16 Disease 9 96.00 Hypoalbuminemia 1 95.56 Leukocytosis 1 93.12 Coagulation Disorder 88 92.76 Diarrhoea 1 90.68 Abdominal Pain 1 89.64 Injury 32 87.84 Increased Venous Pressure Under Development 4 85.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The FDP levels in 10 patients with acute subdural hematoma (ASDH, unpublished) were high (positive in eight cases at a 1:8 dilution and in two cases at a 1:2 dilution).

Gene_expression (levels) of FDP associated with head trauma

1) Confidence 0.11 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628130 Disease Relevance 1.15 Pain Relevance 0.03

We performed the semi-quantitative determination of FDP (fibrinogen degradation product) in plasma and CSDH in all patients by the Latex agglutination method.

Gene_expression (product) of FDP in plasma associated with chronic subdural hematoma

2) Confidence 0.10 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628130 Disease Relevance 0.94 Pain Relevance 0.07

If the FDP concentrations in the CSDH and ASDH fluids were measured by a quantitative method, such as hemagglutination-inhibition immunoassay technique, the gradual increase of FDP levels will be shown as an indicator for a switch from being an ASDH to a CSDH, because fibrinolysis takes place in subdural hematoma continuously.

Gene_expression (concentrations) of FDP associated with head trauma and chronic subdural hematoma

3) Confidence 0.10 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628130 Disease Relevance 1.17 Pain Relevance 0

If the FDP concentrations in the CSDH and ASDH fluids were measured by a quantitative method, such as hemagglutination-inhibition immunoassay technique, the gradual increase of FDP levels will be shown as an indicator for a switch from being an ASDH to a CSDH, because fibrinolysis takes place in subdural hematoma continuously.

Gene_expression (levels) of FDP associated with head trauma and chronic subdural hematoma

4) Confidence 0.10 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628130 Disease Relevance 1.12 Pain Relevance 0

Plasminogen and fibrinogen/fibrin degradation product (FDP) levels were normal in all patients.

Gene_expression (levels) of FDP

5) Confidence 0.07 Published 1975 Journal Blut Section Abstract Doc Link 1203541 Disease Relevance 0.54 Pain Relevance 0.19

Intraoperative levels of FDP were significantly higher and ELT shorter than preoperatively.

Gene_expression (levels) of FDP

6) Confidence 0.05 Published 2001 Journal Eur J Ophthalmol Section Body Doc Link 11284489 Disease Relevance 0.05 Pain Relevance 0

Although prothrombin time and activated partial thromboplastin time were within normal limits, the increased levels of FDP-E, D-dimer, and von Willebrand factor activity were observed, which suggested the endothelial cell activation and the coagulation/fibrinolysis system activation.

Gene_expression (levels) of FDP-E in endothelial cell

7) Confidence 0.01 Published 2000 Journal Nihon Rinsho Meneki Gakkai Kaishi Section Abstract Doc Link 10863331 Disease Relevance 0.88 Pain Relevance 0.12

General Comments

This test has worked.