INT45576

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Context Info
Confidence 0.41
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.41
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ibsp) extracellular region (Ibsp) cell adhesion (Ibsp)
proteinaceous extracellular matrix (Ibsp) extracellular matrix organization (Ibsp)
Anatomy Link Frequency
plasma 2
stromal cells 1
osteoblast 1
Ibsp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 14 98.20 Very High Very High Very High
depression 6 95.60 Very High Very High Very High
cOX1 2 54.64 Quite High
Inflammation 2 44.56 Quite Low
Paracetamol 2 37.36 Quite Low
analgesia 2 34.48 Quite Low
COX2 6 14.96 Low Low
cytokine 2 13.40 Low Low
COX-2 inhibitor 10 5.00 Very Low Very Low Very Low
cINOD 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 115 100.00 Very High Very High Very High
Hypercapnia 8 97.04 Very High Very High Very High
Hypoxia 10 96.60 Very High Very High Very High
Respiratory Failure 6 96.56 Very High Very High Very High
Acidosis 4 95.76 Very High Very High Very High
Lifespan 18 73.92 Quite High
Apoptosis 30 68.12 Quite High
INFLAMMATION 6 44.56 Quite Low
Hypothermia 2 35.76 Quite Low
Fracture Healing 19 32.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Von Knoch et al. showed that a cascade of osteoblast-related genes including BMP-2, cbfa-1, type 1 collagen and Bone Sialo-Proteins (BSP) were up regulated and significantly increased in bone marrow stromal cells after BP treatment [11].
Positive_regulation (increased) of BSP in stromal cells associated with osteoporosis
1) Confidence 0.41 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945066 Disease Relevance 0.46 Pain Relevance 0.03
In these animals, despite normal oxygen, plasma BSP clearance was decreased to 4.4 +/- 0.6 ml X min-1, and liver BSP was increased to 497.9 +/- 65.6 micrograms X g-1.
Positive_regulation (increased) of BSP in plasma
2) Confidence 0.39 Published 1984 Journal Anesthesiology Section Abstract Doc Link 6731907 Disease Relevance 0.90 Pain Relevance 0.56
Similar hypoxia and hypercapnia caused by breathing 9% O2 and 8% CO2 in the absence of morphine caused plasma BSP clearance to be decreased to 4.4 +/- 0.2 ml X min-1 and 40-min hepatic BSP to be increased to 292.5 +/- 31.8 micrograms X g-1.
Positive_regulation (increased) of BSP in plasma associated with hypoxia, hypercapnia and morphine
3) Confidence 0.39 Published 1984 Journal Anesthesiology Section Abstract Doc Link 6731907 Disease Relevance 1.10 Pain Relevance 0.61
The most intense accumulation of markers for both BSP and OPN was observed at electron-dense extracellular areas representing mineralization front/cement lines (Fig. 5) and, to a lesser extent, diffusely spread in the mineralized matrix of woven bone.
Positive_regulation (accumulation) of BSP
4) Confidence 0.35 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2887935 Disease Relevance 0 Pain Relevance 0
It is still unclear how bisphosphonates could stimulate directly bone formation, even if many metabolic pathways have been suggested: the stimulation of b-FGF [10] and of Bone Morphogenetic Protein -2 (BMP-2) [17], the upregulation of a cascade of osteoblast-related genes including BMP-2, cbfa-1, type 1 collagen and Bone Sialo-Proteins (BSP) [18], the influence on OPG/RANKL system [2].
Positive_regulation (upregulation) of BSP in osteoblast associated with osteoporosis
5) Confidence 0.28 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945066 Disease Relevance 0.96 Pain Relevance 0

General Comments

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