INT45597

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Context Info
Confidence 0.59
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 12.47
Pain Relevance 2.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Epo) aging (Epo) extracellular region (Epo)
Anatomy Link Frequency
blood 2
plasma 2
brain 2
granulocyte 1
reticulocytes 1
Epo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 1 100.00 Very High Very High Very High
carpal tunnel syndrome 1 99.30 Very High Very High Very High
ischemia 163 98.84 Very High Very High Very High
antidepressant 21 93.08 High High
anesthesia 12 92.24 High High
Inflammation 26 91.60 High High
fibrosis 4 91.60 High High
peripheral neuropathy 2 90.64 High High
cINOD 1 87.88 High High
backache 1 85.92 High High
Disease Link Frequency Relevance Heat
Neuropathy 68 99.56 Very High Very High Very High
Hypertension 41 99.52 Very High Very High Very High
Carpal Tunnel Syndrome 1 99.30 Very High Very High Very High
Anaemia 59 98.90 Very High Very High Very High
Cv Unclassified Under Development 162 98.84 Very High Very High Very High
Stroke 94 98.72 Very High Very High Very High
Renal Cancer 4 98.52 Very High Very High Very High
Infarction 21 98.10 Very High Very High Very High
Sprains And Strains 1 97.28 Very High Very High Very High
Injury 39 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data show that acute administration of ritodrine reduces fetal and dam plasma EPO, while long-term terbutaline treatment late in gestation alters maternal, but not fetal plasma EPO, indicating that neither drug has any direct regulatory effect on the erythropoietic ability of the fetuses.
Negative_regulation (reduces) of EPO in plasma
1) Confidence 0.59 Published 1994 Journal Biochem. Med. Metab. Biol. Section Abstract Doc Link 7993659 Disease Relevance 0.12 Pain Relevance 0.13
After surgery, the patient's serum EPO level decreased markedly to 15.1 U/L.
Negative_regulation (decreased) of EPO
2) Confidence 0.59 Published 1998 Journal Int. J. Urol. Section Abstract Doc Link 9781442 Disease Relevance 0.60 Pain Relevance 0.09
The data were also analyzed with the separation test by Aickin, which showed a trend toward a reduction of cyclical mastalgia with vitamin E and EPO individually and in combination.
Negative_regulation (reduction) of EPO
3) Confidence 0.58 Published 2010 Journal Altern Med Rev Section Body Doc Link 20359269 Disease Relevance 0.05 Pain Relevance 0
On the basis of suspected pathogenesis, it is also reasonable to limit erythropoietin and iron therapy to dosages ensuring recommended targets and adequately control hyperparathyroidism.
Negative_regulation (limit) of erythropoietin associated with hypercalcemia
4) Confidence 0.57 Published 2007 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 17855637 Disease Relevance 0.89 Pain Relevance 0.30
The drug produced a significant decline in EPO at delivery time, but plasma EPO in the pups was unchanged.
Negative_regulation (decline) of EPO in plasma
5) Confidence 0.43 Published 1994 Journal Biochem. Med. Metab. Biol. Section Abstract Doc Link 7993659 Disease Relevance 0.13 Pain Relevance 0.14
The protective effect of exogenously administered erythropoietin (EPO) has received a great deal of attention for various brain damage in adult animals, and promising data are emerging with perinatal animal models also.
Negative_regulation (effect) of erythropoietin in brain
6) Confidence 0.43 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526527 Disease Relevance 1.34 Pain Relevance 0.18
The protective effect of exogenously administered erythropoietin (EPO) has received a great deal of attention for various brain damage in adult animals, and promising data are emerging with perinatal animal models also.
Negative_regulation (effect) of EPO in brain
7) Confidence 0.43 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526527 Disease Relevance 1.34 Pain Relevance 0.18
Finally, the mechanisms involved in the inhibition of EPO by GM-CSF are the focus of our current research.


Negative_regulation (inhibition) of EPO
8) Confidence 0.42 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0.25 Pain Relevance 0
When three patients with sickle-cell anemia who were not in crisis or infected breathed oxygen at a rate of 5 liters per minute continuously through nasal prongs for five days, there was a rapid decline in erythropoietin levels that had initially been elevated, a delayed fall in the number of reticulocytes, and a fall in the number of irreversibly sickled cells, which, in two of the subjects, preceded the suppression of reticulocytosis.
Negative_regulation (decline) of erythropoietin in reticulocytes associated with anaemia and reticulocytosis
9) Confidence 0.42 Published 1984 Journal N. Engl. J. Med. Section Abstract Doc Link 6738642 Disease Relevance 0.35 Pain Relevance 0
METHODS: Three hundred nine patients with malignant disease who experienced progressive cachexia due to solid tumors (primarily gastrointestinal lesions) were randomized to receive a COX inhibitor (indomethacin, 50 mg twice daily) and EPO (15-40,000 units per week) along with specialized, nutrition-focused patient care (oral nutritional support and home total parenteral nutrition [TPN]) provided on a patient-by-patient basis to attenuate inflammation, prevent anemia, and improve nutritional status.
Negative_regulation (inhibitor) of EPO
10) Confidence 0.41 Published 2004 Journal Cancer Section Body Doc Link 15112279 Disease Relevance 0.26 Pain Relevance 0
Ritodrine administration produced a decrease of dam EPO (23.4 +/- 4.2 to 12.0 +/- 2.9 pmol/ml), while the CTL showed no changes.
Negative_regulation (decrease) of EPO
11) Confidence 0.38 Published 1994 Journal Biochem. Med. Metab. Biol. Section Abstract Doc Link 7993659 Disease Relevance 0.16 Pain Relevance 0.17
A relatively conservative anaemia management practice is seen for HD patients in Japan, employing an average weekly mean Epo dose of 5000–5500 units/week, with 32–33% of patients given IV iron during a 4-month period and receiving an average of ?
Negative_regulation (employing) of Epo associated with anaemia
12) Confidence 0.23 Published 2008 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2568010 Disease Relevance 0.31 Pain Relevance 0
Several mechanisms by which angiotensin converting enzyme blockade may cause a decrease in circulating erythropoietin are discussed.
Negative_regulation (decrease) of erythropoietin
13) Confidence 0.21 Published 1996 Journal Kidney Int. Section Abstract Doc Link 8872973 Disease Relevance 0.32 Pain Relevance 0
The benefits include less frequent occurrence of carpal tunnel syndrome, lower C-reactive protein values, reduced need for erythropoietin, better nutritional status, and even better preservation of residual renal function.
Negative_regulation (reduced) of erythropoietin associated with carpal tunnel syndrome
14) Confidence 0.21 Published 2004 Journal Hemodial Int Section Abstract Doc Link 19379412 Disease Relevance 0.19 Pain Relevance 0.18
A single bolus of EPO has been shown to increase blood number of EPCs (CD34+/CD45?)
Negative_regulation (bolus) of EPO in blood
15) Confidence 0.21 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721378 Disease Relevance 0.75 Pain Relevance 0.12
However, it takes at least a few hours for infarction to fully develop, and various studies have demonstrated that drugs, such as recombinant human erythropoietin [11] and huperzine A [12], a reversible and selective acetylcholinesterase (AChE) inhibitor, injected as late as 6 h after stroke, reduce infarct size [11], [12], [13].
Negative_regulation (inhibitor) of erythropoietin associated with stroke and infarction
16) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588536 Disease Relevance 1.22 Pain Relevance 0.18
Conversely, the hypertensive effects of calcineurin inhibitors and erythropoietin are most commonly overcome by increasing the intensity of antihypertensive drug treatment, since these drugs are essentially unavoidable in most patients who receive them.
Negative_regulation (inhibitors) of erythropoietin associated with hypertension
17) Confidence 0.09 Published 2006 Journal J Clin Hypertens (Greenwich) Section Abstract Doc Link 17028488 Disease Relevance 0.26 Pain Relevance 0.26
Concomitant medication including angiotensin-converting enzyme inhibitors, beta (ß) blockers, lipid-lowering agents or erythropoietin was permitted as recommended by the attending physician.
Negative_regulation (inhibitors) of erythropoietin
18) Confidence 0.09 Published 2008 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2568006 Disease Relevance 0.74 Pain Relevance 0.04
Other significant factors that have been suggested to affect BP pattern are decreased arterial distensibility and erythropoietin therapy in treated hypertensive HD patients (Amar et al 1997).
Negative_regulation (decreased) of erythropoietin associated with hypertension
19) Confidence 0.03 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993946 Disease Relevance 0.52 Pain Relevance 0
Here, we demonstrate that a L. lactis strain containing the nisBTC genes effectively dehydrates and secretes a wide range of medically relevant nonlantibiotic peptides among which variants of adrenocorticotropic hormone, vasopressin, an inhibitor of tripeptidyl peptidase II, enkephalin, luteinizing hormone-releasing hormone, angiotensin, and erythropoietin.
Negative_regulation (variants) of erythropoietin associated with enkephalin and sprains and strains
20) Confidence 0.02 Published 2005 Journal Biochemistry Section Abstract Doc Link 16171398 Disease Relevance 0.19 Pain Relevance 0.10

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