INT4561

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Context Info
Confidence 0.75
First Reported 1975
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 32
Total Number 33
Disease Relevance 17.59
Pain Relevance 6.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PLG) extracellular space (PLG) extracellular region (PLG)
plasma membrane (PLG)
Anatomy Link Frequency
blood 4
macrophages 2
plasma 1
cartilage 1
cleavage 1
PLG (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 530 100.00 Very High Very High Very High
cINOD 17 99.80 Very High Very High Very High
Pain 18 99.64 Very High Very High Very High
Inflammation 217 99.56 Very High Very High Very High
Angina 13 98.40 Very High Very High Very High
rheumatoid arthritis 165 96.32 Very High Very High Very High
bradykinin 1 94.60 High High
Osteoarthritis 61 93.84 High High
Snapping jaw 4 91.64 High High
cytokine 66 89.92 High High
Disease Link Frequency Relevance Heat
Viral Meningitis 43 99.98 Very High Very High Very High
Cancer 163 99.86 Very High Very High Very High
Breast Cancer 473 99.76 Very High Very High Very High
INFLAMMATION 212 99.56 Very High Very High Very High
Thrombosis 25 98.92 Very High Very High Very High
Angina 11 98.40 Very High Very High Very High
Disease 195 98.20 Very High Very High Very High
Cyst 6 98.08 Very High Very High Very High
Pain 16 97.72 Very High Very High Very High
Thyroid Neoplasm 1 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the functional relevance of tPA variants are unknown, over expression of tPA leads to plasmin production, MMP activation and ECM degradation that is commonly associated with fetal membrane rupture and cervical ripening associated with PTB.
Gene_expression (production) of plasmin associated with rupture
1) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553267 Disease Relevance 0.29 Pain Relevance 0.07
The impact of 6-week strenuous exercise training (SET) on blood coagulative and fibrinolytic parameters (levels of fibrinogen, soluble fibrin, fibrinogen-fibrin degradation products, activities of plasminogen and plasmin) was studied in 28 patients with first angina pectoris, in 16 of whom in the first 3 months of onset of the disease, but angina pectoris lasting 3-4 prior to SET.
Gene_expression (levels) of plasmin in blood associated with angina and disease
2) Confidence 0.75 Published 1991 Journal Kardiologiia Section Abstract Doc Link 1895656 Disease Relevance 0.45 Pain Relevance 0.42
Other enzymes such as heparanase and plasmin are produced and secreted from endothelial cells.
Gene_expression (produced) of plasmin in endothelial cells
3) Confidence 0.75 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 0.86 Pain Relevance 0.58
We evaluated the effects of human recombinant tissue-plasminogen activator (hrt-PA), plasmin inhibitors (tranexamic acid, alpha2-antiplasmin, and aprotinin), and anti-inflammatory drugs (betamethasone, NS-398) in wild-type and t-PA(-/-) mice given high-dose or low-dose ibotenic acid.
Gene_expression (effects) of plasmin associated with inflammation and cinod
4) Confidence 0.65 Published 2007 Journal Neuroscience Section Abstract Doc Link 17321054 Disease Relevance 0.61 Pain Relevance 0.26
However, a primary function of the uPA-uPAR couple is to focus the processing of the plasminogen zymogen to active plasmin on the cell surface.
Gene_expression (processing) of plasmin
5) Confidence 0.65 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.37 Pain Relevance 0.21
We evaluated the effects of human recombinant tissue-plasminogen activator (hrt-PA), plasmin inhibitors (tranexamic acid, alpha2-antiplasmin, and aprotinin), and anti-inflammatory drugs (betamethasone, NS-398) in wild-type and t-PA(-/-) mice given high-dose or low-dose ibotenic acid.
Gene_expression (effects) of plasmin associated with inflammation and cinod
6) Confidence 0.65 Published 2007 Journal Neuroscience Section Abstract Doc Link 17321054 Disease Relevance 0.61 Pain Relevance 0.26
However, plasmin also cleaves and activates latent growth factors, latent proMMPs, and protease-activated receptor-1 (PAR-1) on macrophages, which drives macrophage MMP-12 production (Saksela and Rifkin 1988; Taipale et al 1992; Raza et al 2000; Churg et al 2007b).
Gene_expression (cleaves) of plasmin in macrophage
7) Confidence 0.65 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.28 Pain Relevance 0.10
Thrombin and plasmin cleave, thereby activating protease-activated receptor -1 (PAR-1) on macrophages.
Gene_expression (cleave) of plasmin in macrophages
8) Confidence 0.65 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.69 Pain Relevance 0
Horne et al. [5] demonstrated higher concentrations of prothrombin fragment 1 + 2, fibrynogen, factor VIII, antithrombin, tissue plasminogen activator antigen (tPA), plasminogen activator inhibitor 1 (PAI-1), PAI-1/tPA ratio and C-reactive protein in subjects with a history of cured thyroid cancer receiving standard TSH-suppressive L-thyroxine therapy in comparison to concentrations of the above parameters measured in the same subjects in a hypothyroid phase prior to radioiodine whole-body scanning procedure.
Gene_expression (ratio) of plasmin in body associated with thyroid neoplasm
9) Confidence 0.65 Published 2010 Journal Thyroid Res Section Body Doc Link PMC2831875 Disease Relevance 1.18 Pain Relevance 0
Plasminogen and fibrinogen/fibrin degradation product (FDP) levels were normal in all patients.
Gene_expression (levels) of Plasminogen
10) Confidence 0.58 Published 1975 Journal Blut Section Abstract Doc Link 1203541 Disease Relevance 0.55 Pain Relevance 0.20
These results clearly demonstrated increased levels of PA, plasmin and kallikrein activities in the synovial fluid of patients with ID and OA, and suggest that these enzymes may be involved in the pathogenesis of synovitis, as well as the resorption of cartilage and bone in TMJ.
Gene_expression (levels) of plasmin in TMJ associated with snapping jaw, synovitis and osteoarthritis
11) Confidence 0.58 Published 2001 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 11518356 Disease Relevance 0.68 Pain Relevance 0.33
By single proteolytic cleavage, both uPA and plasmin produce active forms of matrix metalloproteinases (MMPs) [16].


Gene_expression (produce) of plasmin in cleavage associated with metalloproteinase
12) Confidence 0.58 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212555 Disease Relevance 0.60 Pain Relevance 0.32
After 4 h incubation at 37°C in MEM supplemented with 10% FCS, the cells were washed twice with phosphate buffered saline (PBS) to remove residual FCS, and incubated for 24 h with 1 ml/well of serum-free MEM with or without the indicated concentrations of plasminogen, TGF?
Gene_expression (concentrations) of plasminogen
13) Confidence 0.52 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.16 Pain Relevance 0.03
However, a primary function of the uPA-uPAR couple is to focus the processing of the plasminogen zymogen to active plasmin on the cell surface.
Gene_expression (processing) of plasminogen zymogen
14) Confidence 0.52 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.37 Pain Relevance 0.18
MMP-1 is expressed by the human breast cancer cells in this study and may contribute to plasmin-dependent fibrillar collagen dissolution.
Gene_expression (dissolution) of plasmin-dependent associated with breast cancer
15) Confidence 0.52 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.43 Pain Relevance 0.22
After 4 h incubation at 37°C in MEM supplemented with 10% FCS, the cells were washed twice with phosphate buffered saline (PBS) to remove residual FCS, and incubated for 24 h with 1 ml/well of serum-free MEM with or without the indicated concentrations of plasminogen, TGF?
Gene_expression (concentrations) of plasminogen
16) Confidence 0.52 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.05 Pain Relevance 0
The urokinase plasminogen activator and its cellular receptor, expressed on the surface of human leukocytes, provide a functional unit that, by regulating interaction of leukocytes with extracellular matrix, as well as its degradation, is critical for the migration of leukocytes and for their movement in the damaged tissues.
Gene_expression (expressed) of plasminogen in leukocytes
17) Confidence 0.51 Published 2008 Journal Front. Biosci. Section Abstract Doc Link 18508538 Disease Relevance 0.67 Pain Relevance 0.37
Cancer cells produce proteinases, including matrix metalloproteinases (MMPs) and the plasminogen activator system (PAS) which promote invasion of extracellular matrices, but whether these proteinases degrade bone matrix is unclear.
Spec (whether) Gene_expression (produce) of plasminogen associated with cancer and metalloproteinase
18) Confidence 0.46 Published 2005 Journal Cancer Cell Int Section Abstract Doc Link PMC548674 Disease Relevance 0.49 Pain Relevance 0.14
During ECM degradation breast cancer cell lines expressed urokinase-type plasminogen activator (u-PA) and uPA receptor, and MMPs-1, -3, -9,-13, and -14.
Gene_expression (expressed) of plasminogen associated with breast cancer and metalloproteinase
19) Confidence 0.46 Published 2005 Journal Cancer Cell Int Section Abstract Doc Link PMC548674 Disease Relevance 0.58 Pain Relevance 0.29
Cancer cells express matrix metalloproteinases (MMPs) and the plasminogen activator system (PAS) [1-3] and their levels of expression increase with progression of the tumour.
Gene_expression (express) of plasminogen associated with cancer and metalloproteinase
20) Confidence 0.46 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 1.09 Pain Relevance 0.51

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