INT45612

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Context Info
Confidence 0.37
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 6.74
Pain Relevance 2.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
leg 1
heart 1
pad (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 14 99.08 Very High Very High Very High
gABA 4 97.94 Very High Very High Very High
Paracetamol 11 96.24 Very High Very High Very High
Restless leg syndrome 18 92.48 High High
Dorsal column 2 92.48 High High
GABAergic 4 87.52 High High
Pain 10 77.04 Quite High
Spinal cord 4 76.28 Quite High
Morphine 4 75.00 Quite High
ischemia 10 57.08 Quite High
Disease Link Frequency Relevance Heat
Peripheral Arterial Disease 166 100.00 Very High Very High Very High
Atherosclerosis 22 99.40 Very High Very High Very High
Coronary Artery Disease 73 98.12 Very High Very High Very High
Increased Venous Pressure Under Development 33 97.64 Very High Very High Very High
Nicotine Addiction 6 97.16 Very High Very High Very High
Diabetes Mellitus 12 96.80 Very High Very High Very High
Hypertension 13 96.04 Very High Very High Very High
Hyperlipidemia 2 95.32 Very High Very High Very High
Cardiovascular Disease 18 85.08 High High
Cerebrovascular Disease 1 84.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In recent years, a number of studies have suggested that the ACE-inhibitor ramipril and different statins, together with antiplatelet drugs, reduce cardiovascular morbidity and mortality in PAD.
Negative_regulation (reduce) of PAD associated with peripheral arterial disease
1) Confidence 0.37 Published 2007 Journal Arch. Med. Res. Section Abstract Doc Link 17560452 Disease Relevance 1.35 Pain Relevance 0.19
Abstract Atherosclerotic peripheral arterial disease (PAD) is highly prevalent in the elderly and subjects with atherosclerotic risk factors such as smoking, diabetes mellitus, hypertension, and hyperlipidemia.
Negative_regulation (prevalent) of PAD associated with nicotine addiction, diabetes mellitus, atherosclerosis, hypertension, hyperlipidemia and peripheral arterial disease
2) Confidence 0.36 Published 2010 Journal Ann. Med. Section Abstract Doc Link 20156042 Disease Relevance 1.44 Pain Relevance 0.07
PAD, a measure of IA2-dependent activity, was not inhibited.
Negative_regulation (inhibited) of PAD associated with peripheral arterial disease
3) Confidence 0.34 Published 1993 Journal Life Sci. Section Abstract Doc Link 8355558 Disease Relevance 0.25 Pain Relevance 0.89
Therefore, diagnosing PAD and prevention of atherothrombotic events with aggressive risk factor modification and antiplatelet therapy will have a great impact on the survival of patients with PAD.
Negative_regulation (diagnosing) of PAD associated with peripheral arterial disease
4) Confidence 0.29 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2293969 Disease Relevance 1.29 Pain Relevance 0.03
In contrast to that study, which was performed with regard to leg functioning parameters on selected patients with high prevalence of PAD, the present investigation was performed on a large-scale general population aged 65 years or older.
Negative_regulation (prevalence) of PAD in leg associated with peripheral arterial disease
5) Confidence 0.16 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1950873 Disease Relevance 0.62 Pain Relevance 0
In the absence of a consistent effect on either threshold or depolarization by GABAmimetics, MENKA reversibly diminished PAD, an action blocked by naloxone.
Negative_regulation (diminished) of PAD associated with narcan and peripheral arterial disease
6) Confidence 0.04 Published 1984 Journal Brain Res. Section Abstract Doc Link 6744025 Disease Relevance 0.36 Pain Relevance 0.66
Moreover, in an apparent paradox, several population-based epidemiologic studies, including the Atherosclerosis Risk in Communities (ARIC) study, have found that women have a lower mean ABI which translates to a higher estimated prevalence of ABI-defined PAD than men, despite having lower prevalences of coronary heart disease [6-11].
Negative_regulation (prevalence) of PAD in heart associated with coronary artery disease, peripheral arterial disease and increased venous pressure under development
7) Confidence 0.03 Published 2007 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1784111 Disease Relevance 1.07 Pain Relevance 0.09
The depolarizations of terminations by GABA or P4S were also reduced, an effect, which for all except MENKA, probably accounted for a concomitant reduction in PAD.
Negative_regulation (reduction) of PAD associated with gaba and peripheral arterial disease
8) Confidence 0.03 Published 1984 Journal Brain Res. Section Abstract Doc Link 6744025 Disease Relevance 0.35 Pain Relevance 0.64

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