INT45613

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Context Info
Confidence 0.50
First Reported 1984
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 24.18
Pain Relevance 4.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neck 1
muscle 1
lower limbs 1
limb 1
ankle 1
pad (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal column 10 99.98 Very High Very High Very High
Restless leg syndrome 81 99.24 Very High Very High Very High
gABA 7 98.44 Very High Very High Very High
Dorsal horn neuron 5 97.04 Very High Very High Very High
c fibre 4 96.84 Very High Very High Very High
Action potential 2 95.00 High High
allodynia 83 94.08 High High
Spinal cord 35 90.20 High High
Dopamine 34 89.32 High High
isoflurane 7 88.88 High High
Disease Link Frequency Relevance Heat
Peripheral Arterial Disease 540 100.00 Very High Very High Very High
Cv Unclassified Under Development 3 99.88 Very High Very High Very High
Increased Venous Pressure Under Development 118 99.84 Very High Very High Very High
Cardiovascular Disease 69 99.76 Very High Very High Very High
Hypertension 52 99.30 Very High Very High Very High
Aging 1 99.24 Very High Very High Very High
Nicotine Addiction 46 99.12 Very High Very High Very High
Diabetes Mellitus 111 99.06 Very High Very High Very High
Cancer 3 96.80 Very High Very High Very High
Necrosis 2 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: Israeli nurses generally are supportive of PAD.
Positive_regulation (supportive) of PAD
1) Confidence 0.50 Published 2001 Journal Oncol Nurs Forum Section Body Doc Link 11198897 Disease Relevance 0.06 Pain Relevance 0
This is despite the fact that PAD patients are an increased mortality rate comparable to those with pre-existing or established cardiovascular disease [myocardial infarction, stroke].
Positive_regulation (increased) of PAD associated with stroke, cardiovascular disease, peripheral arterial disease and myocardial infarction
2) Confidence 0.43 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1166544 Disease Relevance 1.27 Pain Relevance 0.03
This is despite the fact that PAD patients are an increased mortality rate comparable to those with pre-existing or established cardiovascular disease [myocardial infarction, stroke].
Positive_regulation (increased) of PAD associated with stroke, cardiovascular disease, peripheral arterial disease and myocardial infarction
3) Confidence 0.43 Published 2005 Journal BMC Cardiovasc Disord Section Abstract Doc Link PMC1166544 Disease Relevance 0.99 Pain Relevance 0
Patients with PAD are often under-treated for these conditions.
Positive_regulation (under-treated) of PAD associated with peripheral arterial disease
4) Confidence 0.43 Published 2007 Journal Ann Vasc Surg Section Abstract Doc Link 17349357 Disease Relevance 0.87 Pain Relevance 0
With the aging of the population, the prevalence of PAD is increasing.
Positive_regulation (increasing) of PAD associated with aging and peripheral arterial disease
5) Confidence 0.40 Published 2000 Journal J Am Geriatr Soc Section Abstract Doc Link 10983919 Disease Relevance 1.26 Pain Relevance 0.08
This study shows for the first time an increased prevalence of PAD among osteoporotic postmenopausal women, with a lower femoral neck BMD T score being a significant independent predictor.
Positive_regulation (increased) of PAD in neck associated with peripheral arterial disease
6) Confidence 0.32 Published 2006 Journal J. Bone Miner. Metab. Section Abstract Doc Link 16502119 Disease Relevance 0.96 Pain Relevance 0.09
Prevalence estimates of PAD
Positive_regulation (estimates) of PAD associated with peripheral arterial disease
7) Confidence 0.19 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1950873 Disease Relevance 0.48 Pain Relevance 0.09
PAD is mediated by GABAARs on primary afferents where GABA has a depolarizing action.
Positive_regulation (mediated) of PAD associated with gaba and peripheral arterial disease
8) Confidence 0.19 Published 2007 Journal Mol Pain Section Body Doc Link PMC1929059 Disease Relevance 0.84 Pain Relevance 1.30
Similarly, the NHANES study found that after adjusting for traditional cardiovascular disease risk factors, patients with highest quartile of CRP had a 2.1-fold increased odds for PAD [32].
Positive_regulation (increased) of PAD associated with cardiovascular disease and peripheral arterial disease
9) Confidence 0.17 Published 2010 Journal J Int AIDS Soc Section Body Doc Link PMC2859852 Disease Relevance 1.89 Pain Relevance 0.10
A test that is automated, easy to perform, and less reliant on specialized skills, may facilitate the performing of ABI in more number of people in less time, thus increasing the diagnosis of PAD in a susceptible population.[10] The present study utilizes an automated digital BP apparatus to measure the ABI in diabetics and attempts to answer the usefulness of this method in detecting an additional number of PAD cases.
Positive_regulation (increasing) of PAD associated with diabetes mellitus and peripheral arterial disease
10) Confidence 0.13 Published 2010 Journal International Journal of Diabetes in Developing Countries Section Body Doc Link PMC2878698 Disease Relevance 1.17 Pain Relevance 0
Analyses showed a significantly increased risk for PAD with increasing age, smoking, and hypertension.
Positive_regulation (increased) of PAD associated with nicotine addiction, hypertension and peripheral arterial disease
11) Confidence 0.10 Published 2007 Journal Vasc Med Section Abstract Doc Link 17451087 Disease Relevance 1.47 Pain Relevance 0.07
The clinical prediction model giving risk factor points per factor (age: 1 point per 5 years starting at 55 years; ever smoked: 2 points; currently smoking: 7 points; and hypertension: 3 points), showed a proportional increase of the PAD prevalence with each increasing risk profile (range: 7.0-40.6%).
Positive_regulation (increase) of PAD associated with nicotine addiction, hypertension and peripheral arterial disease
12) Confidence 0.09 Published 2007 Journal Vasc Med Section Abstract Doc Link 17451087 Disease Relevance 1.33 Pain Relevance 0.06
In Canadian Oji-Cree subjects with type 2 diabetes, we found that: 1) MTHFR 677T carriers had an increased risk of PAD [OR 3.54 (1.01, 12.4), P = 0.049], adjusting for age, sex, duration of diabetes, hypertension, current smoking habits, and diabetes treatment; and 2) there was no significant association between MTHFR genotype and intermittent claudication, a much more advanced stage of PAD.
Positive_regulation (increased) of PAD associated with nicotine addiction, diabetes mellitus, restless leg syndrome, hypertension and peripheral arterial disease
13) Confidence 0.07 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1308829 Disease Relevance 2.11 Pain Relevance 0.17
In conclusion, we have observed that the presence of the MTHFR 677T allele was significantly associated with an ~3.5-fold increased risk for PAD, as assessed by ABI, in subjects with type 2 diabetes.
Positive_regulation (increased) of PAD associated with diabetes mellitus and peripheral arterial disease
14) Confidence 0.07 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1308829 Disease Relevance 1.12 Pain Relevance 0
Further, the results indicate that conditioned inhibition by DC stimulation of PAD receives a facilitatory influence from the supraspinal structures, whereas that of the synchronized activity of the dorsal horn neurons does not.
Positive_regulation (stimulation) of PAD in dorsal horn associated with peripheral arterial disease, dorsal horn neuron and dorsal column
15) Confidence 0.06 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12873931 Disease Relevance 0.35 Pain Relevance 0.91
However, under inflamed conditions, PAD may be enhanced such that it leads to excessive depolarization of A?
Positive_regulation (enhanced) of PAD associated with peripheral arterial disease
16) Confidence 0.05 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 0.92 Pain Relevance 0.58
PAD is caused by atherosclerosis in the leg arteries, which leads to a reduction in blood supply to the lower limbs.
Positive_regulation (caused) of PAD in lower limbs associated with increased venous pressure under development and peripheral arterial disease
17) Confidence 0.05 Published 2010 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2958933 Disease Relevance 1.41 Pain Relevance 0.45
As expected, lowering the ABI cutpoint to define PAD to 0.85 for women increased the estimated HR to 3.31 in white women and 2.76 in black women; the statistical significance of the gender difference in HR decreased in both whites (P = 0.69) and blacks (P = 0.22).
Positive_regulation (define) of PAD associated with peripheral arterial disease
18) Confidence 0.04 Published 2007 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1784111 Disease Relevance 1.19 Pain Relevance 0
Based on the evaluated studies, we find that the lower ankle pressure ABI has better sensitivity in diagnosing PAD.
Positive_regulation (diagnosing) of PAD in ankle associated with peripheral arterial disease
19) Confidence 0.04 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2779349 Disease Relevance 0.84 Pain Relevance 0
Atherosclerosis is the major cause of PAD of lower extremities [2].
Positive_regulation (cause) of PAD associated with peripheral arterial disease and increased venous pressure under development
20) Confidence 0.04 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2779349 Disease Relevance 0.80 Pain Relevance 0

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