INT4562

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Context Info
Confidence 0.53
First Reported 1975
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.45
Pain Relevance 3.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 1
platelet 1
sympathetic nervous system 1
heart 1
EPI 1
Slc6a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 6 100.00 Very High Very High Very High
Serotonin 23 99.90 Very High Very High Very High
Dopamine 24 99.84 Very High Very High Very High
Clonidine 16 99.20 Very High Very High Very High
Desipramine 14 99.06 Very High Very High Very High
rheumatoid arthritis 2 97.00 Very High Very High Very High
Inflammation 2 96.80 Very High Very High Very High
Pain 2 93.44 High High
agonist 4 92.72 High High
Catecholamine 3 92.32 High High
Disease Link Frequency Relevance Heat
Experimental Arthritis 6 100.00 Very High Very High Very High
Cv Unclassified Under Development 3 99.44 Very High Very High Very High
Rheumatoid Arthritis 2 97.00 Very High Very High Very High
INFLAMMATION 2 96.80 Very High Very High Very High
Arthralgia 2 93.68 High High
Headache 1 90.44 High High
Reprotox - General 2 3 75.28 Quite High
Cognitive Disorder 10 72.72 Quite High
Hypoxia 1 34.48 Quite Low
Sleep Disorders 16 25.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additional studies are needed to clarify the mechanism of the DMI-induced increase in NET mRNA and to correlate changes in NET mRNA with transporter expression at the synaptic membrane.
Regulation (changes) of NET associated with desipramine
1) Confidence 0.53 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7898321 Disease Relevance 0 Pain Relevance 1.11
Immunoreactivity of norepinephrine transporter (NET) was localized to ICA cells in rat heart tissue and primary cell culture.
Regulation (Immunoreactivity) of NET in heart
2) Confidence 0.26 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15458949 Disease Relevance 0 Pain Relevance 0.15
Effect of the norepinephrine receptor stimulating agent "clonidine" on the turnover of 5-hydroxytryptamine in some areas of the rat brain.
Regulation (Effect) of norepinephrine receptor in brain associated with clonidine
3) Confidence 0.24 Published 1975 Journal J. Neural Transm. Section Title Doc Link 1206391 Disease Relevance 0 Pain Relevance 0.41
We tested the effect of adjuvant arthritis on the norepinephrine (NE) transporter (NET) density since altered sympathetic nervous system innervation has been observed in rheumatoid arthritis.
Regulation (effect) of NET in sympathetic nervous system associated with rheumatoid arthritis, experimental arthritis and arthritis
4) Confidence 0.22 Published 2009 Journal J Pharm Pharm Sci Section Abstract Doc Link 20067708 Disease Relevance 0.52 Pain Relevance 0.44
Norepinephrine transporter is involved in down-regulation of beta1-adrenergic receptors caused by adjuvant arthritis.
Regulation (involved) of Norepinephrine transporter associated with experimental arthritis and arthritis
5) Confidence 0.13 Published 2009 Journal J Pharm Pharm Sci Section Title Doc Link 20067708 Disease Relevance 0.46 Pain Relevance 0.44
Though the recent paper by Madras and colleagues indicates that modafinil has some physiologically significant effect on the DAT and possibly the NET, not all of modafinil’s effect are likely mediated by this particular mechanism, as the investigators themselves suggest.
Spec (possibly) Regulation (effect) of NET
6) Confidence 0.04 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654794 Disease Relevance 0 Pain Relevance 0.14
The recent development of selective epinephrine (EPI) synthesis inhibitors has made it possible to disrupt central EPI neurotransmission without affecting norepinephrine or dopamine.
Neg (without) Regulation (affecting) of norepinephrine in EPI associated with dopamine
7) Confidence 0.02 Published 1982 Journal Peptides Section Abstract Doc Link 6750566 Disease Relevance 0 Pain Relevance 0.21
The article includes a discussion of presumed pharmacologic mechanisms, including effects on platelet activating factor, prostaglandins, peripheral vasodilatation, and central serotonin and norepinephrine receptor factor modulation.
Regulation (modulation) of norepinephrine receptor in platelet associated with cv unclassified under development and serotonin
8) Confidence 0.02 Published 1998 Journal J Sex Marital Ther Section Abstract Doc Link 9611693 Disease Relevance 0.46 Pain Relevance 0.54

General Comments

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