INT4563

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Context Info
Confidence 0.70
First Reported 1975
Last Reported 2008
Negated 6
Speculated 1
Reported most in Abstract
Documents 20
Total Number 21
Disease Relevance 4.20
Pain Relevance 8.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl)
Anatomy Link Frequency
plasma 4
follicle 2
platelets 2
EPI 2
body 2
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 33 100.00 Very High Very High Very High
Opioid 26 99.98 Very High Very High Very High
Morphine 16 99.92 Very High Very High Very High
Endogenous opioid 5 99.84 Very High Very High Very High
Clonidine 9 99.70 Very High Very High Very High
Serotonin 5 99.60 Very High Very High Very High
agonist 16 96.12 Very High Very High Very High
Dopamine 33 95.24 Very High Very High Very High
depression 4 94.64 High High
opiate 7 94.44 High High
Disease Link Frequency Relevance Heat
Heat Stress Disorders 1 99.92 Very High Very High Very High
Hypoglycemia 3 99.52 Very High Very High Very High
Chronic Renal Failure 6 99.28 Very High Very High Very High
Obesity 6 98.88 Very High Very High Very High
Stress 18 97.78 Very High Very High Very High
Acute Coronary Syndrome 7 97.36 Very High Very High Very High
Cancer 1 96.92 Very High Very High Very High
Overnutrition 5 96.48 Very High Very High Very High
Galactorrhea 7 91.64 High High
Myocardial Infarction 2 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that the early developing, serotonin-independent opioid regulation of PRL is mediated through kappa-receptors, while the later-developing mechanism which requires intact serotonergic transmission works through mu-receptors. kappa-Receptors appear to regulate PRL secretion by directly inhibiting the activity of tuberoinfundibular dopamine neurons, while mu-receptors might regulate the tonic dopaminergic inhibition of PRL through a serotonergic pathway.
Positive_regulation (mediated) of Neg (independent) Regulation (regulation) of PRL in dopamine neurons associated with dopamine, opioid and serotonin
1) Confidence 0.70 Published 1987 Journal Brain Res. Section Abstract Doc Link 2894234 Disease Relevance 0 Pain Relevance 0.90
In normal male rats, the intraventricular injection of 0.25 micrograms/kg of dermorphin is not able to induce any significant changes in serum Prl levels 10 min after injection.
Positive_regulation (induce) of Regulation (changes) of Prl
2) Confidence 0.50 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6504268 Disease Relevance 0.09 Pain Relevance 0.32
Restraint stress induced a marked increase of plasma PRL of control rats with a peak at 15 min (increase of 403%), but did not change the PRL levels of hyperprolactinemic rats.
Neg (not) Positive_regulation (change) of Neg (not) Regulation (change) of PRL in plasma associated with stress
3) Confidence 0.47 Published 1996 Journal Life Sci. Section Abstract Doc Link 8606624 Disease Relevance 0.60 Pain Relevance 0.09
IDZ significantly lowered plasma PRL levels in OET rats; no elevated PRL values were observed in normal cycling rats, indicating that IDZ might inhibit PRL surges in these animals.
Neg (no) Positive_regulation (elevated) of Neg (no) Regulation (values) of PRL in plasma
4) Confidence 0.47 Published 1991 Journal Horm. Metab. Res. Section Abstract Doc Link 2016076 Disease Relevance 0.24 Pain Relevance 0.12
We explored the role of the opioid system and the participation of ovarian hormones in the regulation of prolactin induced by the suckling stimulus at the end of pregnancy in rats with developed maternal behavior, and during lactation.
Positive_regulation (induced) of Regulation (regulation) of prolactin associated with opioid
5) Confidence 0.47 Published 2002 Journal J. Endocrinol. Section Abstract Doc Link 11834443 Disease Relevance 0 Pain Relevance 0.37
Prolactin response to breast stimulation in lactating women is not mediated by endogenous opioids.
Neg (not) Positive_regulation (mediated) of Regulation (response) of Prolactin associated with narcan and endogenous opioid
6) Confidence 0.47 Published 1984 Journal Am. J. Obstet. Gynecol. Section Title Doc Link 6496587 Disease Relevance 0 Pain Relevance 0.49
They were considerably more potent than morphine in triggering a PRL response, but were unable to elevate PRL levels to more than 100 ng/ml, whereas morphine, at the highest dose (4.5 mg/kg), induced an almost twice larger response.
Positive_regulation (triggering) of Regulation (response) of PRL associated with morphine
7) Confidence 0.46 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3001565 Disease Relevance 0 Pain Relevance 1.29
Results suggest a catecholaminergic mediation of the prolactin and LH responses induced by acetylcholin in male rats.
Positive_regulation (induced) of Regulation (responses) of prolactin
8) Confidence 0.46 Published 1975 Journal J. Neural Transm. Section Abstract Doc Link 1206392 Disease Relevance 0 Pain Relevance 0.12
Both Comp B and antisense pretreatment blocked the stimulatory effects of OFQ/N on prolactin release, and Comp B abolished the suckling-induced prolactin response.
Positive_regulation (induced) of Regulation (response) of prolactin
9) Confidence 0.45 Published 2006 Journal Endocrinology Section Abstract Doc Link 16887913 Disease Relevance 0 Pain Relevance 0.20
Furthermore, the suckling-induced prolactin response was also determined after Comp B pretreatment.
Positive_regulation (induced) of Regulation (response) of prolactin
10) Confidence 0.45 Published 2006 Journal Endocrinology Section Abstract Doc Link 16887913 Disease Relevance 0 Pain Relevance 0.36
The stimulatory effect of DAMGO on blood pressure, HR, and plasma EPI and ACTH was attenuated, but the PRL response was enhanced in aged cohorts.
Positive_regulation (enhanced) of Regulation (response) of PRL in EPI
11) Confidence 0.45 Published 1992 Journal J Gerontol Section Abstract Doc Link 1315352 Disease Relevance 0 Pain Relevance 0.41
Although clinical anomographic changes preceded elevation of prolactin values in two cases and, in one case, clinical indications and an elevated prolactin value preceded tomographic changes.
Positive_regulation (elevation) of Regulation (values) of prolactin
12) Confidence 0.42 Published 1980 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 7189327 Disease Relevance 0.43 Pain Relevance 0
CONCLUSION(S): Chronic blockade of opioid activities during the follicular phase does not affect midcycle prolactin increments, but withdrawal of opioid blockade may enhance opioid effects on prolactin levels in the luteal phase.


Spec (may) Positive_regulation (enhance) of Regulation (effects) of prolactin
13) Confidence 0.42 Published 1997 Journal Fertil. Steril. Section Body Doc Link 9389815 Disease Relevance 0 Pain Relevance 0
However, clonidine was unable to induce changes in CRT, GH, and PRL mean levels in any depressed group.
Neg (unable) Positive_regulation (induce) of Neg (unable) Regulation (changes) of PRL associated with clonidine
14) Confidence 0.41 Published 1985 Journal Neuroendocrinology Section Abstract Doc Link 4047333 Disease Relevance 0.08 Pain Relevance 0.52
Brisson et al. [43,44] demonstrated that a body-temperature threshold value had to be reached for heat stress to induce a significant blood Prl response during active or passive heat exposure.
Positive_regulation (induce) of Regulation (response) of Prl in body associated with heat stress disorders
15) Confidence 0.35 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2570654 Disease Relevance 0.10 Pain Relevance 0.05
Neither saline nor naloxone caused any significant change in luteinising hormone, follicle-stimulating hormone or prolactin in patients with chronic renal failure.
Neg (Neither) Positive_regulation (caused) of Regulation (change) of prolactin in follicle associated with chronic renal failure and narcan
16) Confidence 0.33 Published 1985 Journal Proc Eur Dial Transplant Assoc Eur Ren Assoc Section Abstract Doc Link 3991553 Disease Relevance 0.35 Pain Relevance 0.43
Moreover, in 5 other euthyroid volunteers, morphine significantly enhanced the response of TSH and PRL to TRH stimulation (200 micrograms i.v.).
Positive_regulation (enhanced) of Regulation (response) of PRL associated with morphine
17) Confidence 0.33 Published 1985 Journal Neuroendocrinology Section Abstract Doc Link 3921862 Disease Relevance 0 Pain Relevance 0.91
Effects of naloxone on prolactin, growth hormone and cortisol response to insulin hypoglycemia in obese subjects.
Positive_regulation (response) of Regulation (Effects) of prolactin associated with hypoglycemia, obesity and narcan
18) Confidence 0.32 Published 1989 Journal J. Endocrinol. Invest. Section Title Doc Link 2693516 Disease Relevance 0.76 Pain Relevance 0.59
The treatment did not modify basal prolactin and growth hormone levels, but prolactin response to thyrotropin releasing hormone was enhanced.
Positive_regulation (enhanced) of Regulation (response) of prolactin
19) Confidence 0.16 Published 1990 Journal Cephalalgia Section Abstract Doc Link 2107977 Disease Relevance 0.25 Pain Relevance 0.21
In females, the prolactin response to protirelin was similarly not increased, but the prolactin response to tryptophan was markedly enhanced.
Positive_regulation (enhanced) of Regulation (response) of prolactin
20) Confidence 0.15 Published 1987 Journal Arch. Gen. Psychiatry Section Abstract Doc Link 3675135 Disease Relevance 0.41 Pain Relevance 0.56

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