INT45636

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Context Info
Confidence 0.09
First Reported 1984
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.95
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
outflow 1
spinal 1
spinal cord 1
Melm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spontaneous pain 2 99.72 Very High Very High Very High
Spinal cord 39 99.32 Very High Very High Very High
rheumatoid arthritis 6 96.88 Very High Very High Very High
Enkephalin 24 96.00 Very High Very High Very High
Lasting pain 2 87.68 High High
central sensitization 4 83.60 Quite High
Cancer pain 2 77.44 Quite High
Dorsal horn 15 76.56 Quite High
Pain 24 75.72 Quite High
Cholecystokinin 1 74.48 Quite High
Disease Link Frequency Relevance Heat
Pain 24 99.72 Very High Very High Very High
Rheumatoid Arthritis 6 96.88 Very High Very High Very High
Arthritis 2 92.64 High High
Metastasis 4 78.08 Quite High
Cancer Pain 2 77.44 Quite High
Nociception 16 68.96 Quite High
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Paralysis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When the extracellular levels of enkephalins are elevated by the blockade of their enzymatic degradation (e.g. by kelatorphan), a noxious mechanical stimulation is as efficient as in the absence of the peptidase inhibitor for producing a sharp increase in MELM outflow: absolute levels of released MELM were higher, but the relative effect of the noxious stimulation was identical [4].
Positive_regulation (increase) of MELM in outflow associated with enkephalin
1) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731161 Disease Relevance 0.06 Pain Relevance 0.35
Increased basal tissue concentration of MELM was seen in the spinal cord of these animals [37] and this was associated with a clear reduction of release [38].
Positive_regulation (Increased) of MELM in spinal cord associated with spinal cord
2) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731161 Disease Relevance 0.90 Pain Relevance 0.95
Further experiments performed with tissues of polyarthritic rats indicated that the increase in their MELM levels was associated with a lower fractional rate constant of MELM release, therefore suggesting that spinal Met-enkephalin turnover might be reduced in chronically suffering animals.
Positive_regulation (increase) of MELM in spinal associated with enkephalin
3) Confidence 0.02 Published 1984 Journal J. Neurochem. Section Abstract Doc Link 6747633 Disease Relevance 0 Pain Relevance 0.51

General Comments

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