INT45645

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Context Info
Confidence 0.11
First Reported 1982
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.07
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Erap1) extracellular region (Erap1) endoplasmic reticulum (Erap1)
cytoplasm (Erap1)
Anatomy Link Frequency
brain 1
Erap1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 11 98.34 Very High Very High Very High
Central nervous system 2 66.80 Quite High
opioid receptor 1 63.76 Quite High
Analgesic 1 25.00 Low Low
nociceptor 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Nociception 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of thiorphan on brain met5-enkephalin content and hot plate latencies were significantly potentiated by bestatin, which inhibits aminopeptidase B and leucine aminopeptidase.
Negative_regulation (inhibits) of leucine aminopeptidase in brain associated with enkephalin
1) Confidence 0.11 Published 1982 Journal Neuropharmacology Section Abstract Doc Link 6750433 Disease Relevance 0.07 Pain Relevance 0.49
Inhibition of leucine aminopeptidase with bestatin in the serum increased the conversion time of Phe0-DPDPE from 6.8 min to 92.2 min.
Negative_regulation (Inhibition) of leucine aminopeptidase
2) Confidence 0.06 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8667199 Disease Relevance 0 Pain Relevance 0.27

General Comments

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