INT45665

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Context Info
Confidence 0.13
First Reported 1982
Last Reported 1982
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 1.00

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peptidase activity (Mme) plasma membrane (Mme) signal transducer activity (Fpr1)
Fpr1 (Rattus norvegicus)
Mme (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 21 100.00 Very High Very High Very High
analgesia 3 25.00 Low Low
Intracerebroventricular 3 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The N-phosphorylated dipeptide K2PO3-Leu-Phe (P-Leu-Phe) and the mercaptoacetylated dipeptides SHCH2CO-Leu-Phe and SHCH2CO-Phe-Leu are potent inhibitors of the enkephalin carboxydipeptidase (enkephalinase) activity from rat striatal synaptosomal membranes; IC50, 0.3 nM, 15 nM, and 70 nM, respectively.
SHCH2CO-Phe-Leu Negative_regulation (inhibitors) of enkephalinase associated with enkephalin
1) Confidence 0.13 Published 1982 Journal Adv. Biochem. Psychopharmacol. Section Abstract Doc Link 6751033 Disease Relevance 0 Pain Relevance 0.33
The N-phosphorylated dipeptide K2PO3-Leu-Phe (P-Leu-Phe) and the mercaptoacetylated dipeptides SHCH2CO-Leu-Phe and SHCH2CO-Phe-Leu are potent inhibitors of the enkephalin carboxydipeptidase (enkephalinase) activity from rat striatal synaptosomal membranes; IC50, 0.3 nM, 15 nM, and 70 nM, respectively.
P-Leu-Phe Negative_regulation (inhibitors) of enkephalinase associated with enkephalin
2) Confidence 0.13 Published 1982 Journal Adv. Biochem. Psychopharmacol. Section Abstract Doc Link 6751033 Disease Relevance 0 Pain Relevance 0.33
The N-phosphorylated dipeptide K2PO3-Leu-Phe (P-Leu-Phe) and the mercaptoacetylated dipeptides SHCH2CO-Leu-Phe and SHCH2CO-Phe-Leu are potent inhibitors of the enkephalin carboxydipeptidase (enkephalinase) activity from rat striatal synaptosomal membranes; IC50, 0.3 nM, 15 nM, and 70 nM, respectively.
SHCH2CO-Leu-Phe Negative_regulation (inhibitors) of enkephalinase associated with enkephalin
3) Confidence 0.06 Published 1982 Journal Adv. Biochem. Psychopharmacol. Section Abstract Doc Link 6751033 Disease Relevance 0 Pain Relevance 0.33

General Comments

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