INT45672

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Context Info
Confidence 0.43
First Reported 1982
Last Reported 1999
Negated 2
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.66
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Serpina6) extracellular space (Serpina6) extracellular region (Serpina6)
molecular_function (Serpina6) cellular_component (Serpina6) biological_process (Serpina6)
Serpina6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
backache 2 99.90 Very High Very High Very High
Morphine 17 99.80 Very High Very High Very High
headache 2 98.80 Very High Very High Very High
anesthesia 2 88.12 High High
corticosteroid 6 78.64 Quite High
Disease Link Frequency Relevance Heat
Reprotox - General 1 2 100.00 Very High Very High Very High
Back Pain 2 99.90 Very High Very High Very High
Dyspnea 2 99.70 Very High Very High Very High
Sleep Initiation And Maintenance Disorders 2 99.10 Very High Very High Very High
Headache 2 98.80 Very High Very High Very High
Heart Rate Under Development 2 98.30 Very High Very High Very High
Dizziness 2 98.02 Very High Very High Very High
Stress 5 94.48 High High
Endometriosis (extended) 4 75.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In any case, it is evident that morphine does not decrease the level of physiologically active corticosterone through CBG in females as it appears to do in males.
Neg (not) Negative_regulation (decrease) of CBG associated with morphine
1) Confidence 0.43 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9694945 Disease Relevance 0 Pain Relevance 0.72
However, due to the elevated level of CBG, the amount of free, physiologically active hormone was dramatically reduced.
Negative_regulation (reduced) of CBG
2) Confidence 0.43 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9316834 Disease Relevance 0.09 Pain Relevance 0.81
In females, ether, swimming, swimming after fasting, fasting, and fasting during cold exposure resulted in a decrease in circulating CBG.
Negative_regulation (decrease) of CBG
3) Confidence 0.38 Published 1999 Journal Endocrine Section Abstract Doc Link 10709761 Disease Relevance 0.20 Pain Relevance 0.22
SHBG levels were slightly suppressed, whereas F and CBG levels were unaffected.
Neg (unaffected) Negative_regulation (unaffected) of CBG
4) Confidence 0.00 Published 1982 Journal Reproduccion Section Abstract Doc Link 6754512 Disease Relevance 0.52 Pain Relevance 0.13
Data on the following variables were obtained and analysed by the non-parametric randomization test for paired observations: hot flushes, sweating, dizziness, palpitations, fatiguability, headache, sleeplessness, irritability, breathlessness, backache and loss of libido and, in 16 patients, on circulating levels of FSH, LH, PRL, T3, T4, cortisol (F), SHBG, TBG and CBG.
Negative_regulation (loss) of CBG associated with sleep initiation and maintenance disorders, heart rate under development, dizziness, headache, dyspnea, reprotox - general 1 and backache
5) Confidence 0.00 Published 1982 Journal Reproduccion Section Abstract Doc Link 6754512 Disease Relevance 0.84 Pain Relevance 0.20

General Comments

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