INT45673

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.53
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 3.47
Pain Relevance 3.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Serpina6) extracellular space (Serpina6) extracellular region (Serpina6)
molecular_function (Serpina6) cellular_component (Serpina6) biological_process (Serpina6)
Anatomy Link Frequency
pituitary 1
hippocampus 1
Serpina6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
corticosteroid 22 100.00 Very High Very High Very High
Hippocampus 6 99.68 Very High Very High Very High
fluoxetine 10 99.46 Very High Very High Very High
antidepressant 12 99.26 Very High Very High Very High
backache 4 98.88 Very High Very High Very High
iatrogenic 1 98.88 Very High Very High Very High
headache 14 97.78 Very High Very High Very High
anesthesia 2 94.08 High High
Opioid 1 88.56 High High
Serotonin 5 79.92 Quite High
Disease Link Frequency Relevance Heat
Reprotox - General 1 41 99.26 Very High Very High Very High
Back Pain 1 98.88 Very High Very High Very High
Dyspnea 1 98.68 Very High Very High Very High
Sleep Initiation And Maintenance Disorders 1 98.08 Very High Very High Very High
Adrenal Insufficiency 7 98.00 Very High Very High Very High
Headache 18 97.78 Very High Very High Very High
Heart Rate Under Development 1 97.28 Very High Very High Very High
Dizziness 1 97.00 Very High Very High Very High
Disease 3 94.80 High High
Disorder Of Lipid Metabolism 6 92.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum CBG was considerably higher in females.
Gene_expression (higher) of CBG
1) Confidence 0.53 Published 1999 Journal Endocrine Section Abstract Doc Link 10709761 Disease Relevance 0.20 Pain Relevance 0.24
5% were selected for CRH, CRHBP, CRHR1, POMC, MC2R, NR3C1 and SERPINA6 and their 10 kb flanking regions using Tagger.24 SNPs were genotyped using Sequenom MassARRAY technology following the manufacturer's instructions (http://www.sequenom.com).
Gene_expression (selected) of SERPINA6
2) Confidence 0.52 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2927682 Disease Relevance 0.56 Pain Relevance 0.14
Salivary cortisol measurement was reported to have an equivalent diagnostic performance to serum cortisol and that is even better when CBG levels are altered.
Gene_expression (levels) of CBG
3) Confidence 0.51 Published 2008 Journal Ann. Endocrinol. (Paris) Section Abstract Doc Link 18954859 Disease Relevance 0.70 Pain Relevance 0.18
Thus antidepressants can have complex and opposing actions on hippocampal corticosteroid receptor expression depending on the duration of treatment.
Gene_expression (expression) of corticosteroid receptor associated with corticosteroid and antidepressant
4) Confidence 0.37 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11406320 Disease Relevance 0 Pain Relevance 0.59
Chronic treatment with antidepressant drugs (2 weeks or longer) increases corticosteroid receptor mRNA expression in the hippocampus and reduces hypothalamic-pituitary-adrenal axis activity in parallel with improving mood and neuroendocrine function.
Gene_expression (expression) of corticosteroid receptor in pituitary associated with corticosteroid, antidepressant and hippocampus
5) Confidence 0.37 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11406320 Disease Relevance 0 Pain Relevance 0.41
Short-term administration of fluoxetine and venlafaxine decreases corticosteroid receptor mRNA expression in the rat hippocampus.
Gene_expression (expression) of corticosteroid receptor in hippocampus associated with corticosteroid, hippocampus and fluoxetine
6) Confidence 0.37 Published 2001 Journal Neurosci. Lett. Section Title Doc Link 11406320 Disease Relevance 0 Pain Relevance 0.62
The present set of studies examined the effect of para-chloroamphetamine (PCA) administration on both short-term and long-term regulation of hippocampal 5-HT and corticosteroid receptor levels.
Gene_expression (levels) of corticosteroid receptor associated with corticosteroid
7) Confidence 0.21 Published 1995 Journal Brain Res. Section Abstract Doc Link 7583200 Disease Relevance 0 Pain Relevance 0.34
Sex-hormone-binding globulin increased markedly more with NuvaRing, whereas corticosteroid-binding globulin levels increased to a lesser degree.
Gene_expression (levels) of corticosteroid-binding globulin associated with corticosteroid
8) Confidence 0.04 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2990910 Disease Relevance 0.50 Pain Relevance 0.05
Data on the following variables were obtained and analysed by the non-parametric randomization test for paired observations: hot flushes, sweating, dizziness, palpitations, fatiguability, headache, sleeplessness, irritability, breathlessness, backache and loss of libido and, in 16 patients, on circulating levels of FSH, LH, PRL, T3, T4, cortisol (F), SHBG, TBG and CBG.
Gene_expression (levels) of CBG associated with sleep initiation and maintenance disorders, heart rate under development, dizziness, headache, dyspnea, reprotox - general 1 and backache
9) Confidence 0.01 Published 1982 Journal Reproduccion Section Abstract Doc Link 6754512 Disease Relevance 0.84 Pain Relevance 0.20
In users of the DNG-containing oral contraceptives, the reduction in total and free protein S, and in t-PA and PAI was dependent on the EE dose, while factor VII activity was elevated, but not significantly different from that with EE/LNG.13 The levels of high-density lipoprotein cholesterol increased, while the levels of prothrombin fragment 1 + 2 and D-dimer remained relatively unchanged; in contrast, the levels of SHBG, CBG and TBG increased.38
Gene_expression (levels) of CBG
10) Confidence 0.01 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2990895 Disease Relevance 0.67 Pain Relevance 0.23

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox