INT45675

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Context Info
Confidence 0.15
First Reported 1982
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 4.65
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Shbg) extracellular region (Shbg)
Anatomy Link Frequency
nerve 2
Shbg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
headache 11 100.00 Very High Very High Very High
backache 1 100.00 Very High Very High Very High
transcutaneous nerve stimulation 1 100.00 Very High Very High Very High
Neurotransmitter 2 99.80 Very High Very High Very High
transdermal 63 99.58 Very High Very High Very High
Dopamine 6 82.96 Quite High
cva 17 78.08 Quite High
Inflammation 4 69.84 Quite High
Pain 7 67.56 Quite High
cytokine 3 63.36 Quite High
Disease Link Frequency Relevance Heat
Reprotox - General 1 29 100.00 Very High Very High Very High
Headache 14 100.00 Very High Very High Very High
Reprotox - General 2 2 100.00 Very High Very High Very High
Back Pain 1 100.00 Very High Very High Very High
Sleep Initiation And Maintenance Disorders 1 100.00 Very High Very High Very High
Heart Rate Under Development 1 100.00 Very High Very High Very High
Dizziness 1 100.00 Very High Very High Very High
Dyspnea 1 100.00 Very High Very High Very High
Endometriosis (extended) 54 99.52 Very High Very High Very High
Hypertension 8 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The steady state is reached after 3 days which is not influenced by SHBG levels.
Neg (not) Regulation (influenced) of Gene_expression (levels) of SHBG
1) Confidence 0.15 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2990895 Disease Relevance 0.06 Pain Relevance 0.06
Data on the following variables were obtained and analysed by the non-parametric randomization test for paired observations: hot flushes, sweating, dizziness, palpitations, fatiguability, headache, sleeplessness, irritability, breathlessness, backache and loss of libido and, in 16 patients, on circulating levels of FSH, LH, PRL, T3, T4, cortisol (F), SHBG, TBG and CBG.
Regulation (analysed) of Gene_expression (levels) of SHBG associated with sleep initiation and maintenance disorders, heart rate under development, dizziness, headache, dyspnea, reprotox - general 1 and backache
2) Confidence 0.11 Published 1982 Journal Reproduccion Section Abstract Doc Link 6754512 Disease Relevance 0.86 Pain Relevance 0.20
In the treatment of stage II hypertensive patient the FDC of T40+A5 (Telar-AM) was found to be significantly effective in the reduction of SBP as well as DBP.
Regulation (effective) of Gene_expression (reduction) of SBP associated with hypertension
3) Confidence 0.08 Published 2008 Journal J Indian Med Assoc Section Abstract Doc Link 19552093 Disease Relevance 0.87 Pain Relevance 0.09
Diosgenin, the main steroidal saponin in dioscorea [14,15], is used to manufacture steroidal hormones, such as progesterone, estrogen, testosterone, and cortisone [16,17], by in vitro chemical modification [18]; however, a recent study on menopausal animals indicated that sex hormone levels might not be affected by diosgenin treatment [19].
Neg (not) Spec (might) Regulation (affected) of Gene_expression (levels) of sex hormone associated with endometriosis (extended)
4) Confidence 0.07 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 1.00 Pain Relevance 0.13
Conversely, transdermal estrogen has little effect on SHBG production or circulating free testosterone.
Neg (little) Regulation (effect) of Gene_expression (production) of SHBG associated with transdermal
5) Confidence 0.05 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761184 Disease Relevance 0.60 Pain Relevance 0.33
Changes in serum sex hormone levels and neurotransmitter levels are shown in Table 2.
Regulation (Changes) of Gene_expression (levels) of sex hormone associated with neurotransmitter
6) Confidence 0.04 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2855479 Disease Relevance 1.10 Pain Relevance 0.12
[Effect of 2/100 Hz transcutaneous electrical nerve stimulation on sexual dysfunction and serum sex hormone of heroin addicts].
Regulation ([Effect) of Gene_expression (dysfunction) of serum sex hormone in nerve associated with reprotox - general 2 and transcutaneous nerve stimulation
7) Confidence 0.00 Published 2000 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Title Doc Link 11783327 Disease Relevance 0.10 Pain Relevance 0.10

General Comments

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