INT45692

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Context Info
Confidence 0.49
First Reported 1982
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.07
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PRSS1) extracellular space (PRSS1) extracellular region (PRSS1)
Anatomy Link Frequency
plasma 2
pancreas 2
PRSS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 41 100.00 Very High Very High Very High
Catecholamine 5 100.00 Very High Very High Very High
Serotonin 2 100.00 Very High Very High Very High
Neurotransmitter 31 98.88 Very High Very High Very High
abdominal pain 10 94.68 High High
Chronic pancreatitis 391 94.56 High High
Calcitonin gene-related peptide 11 81.20 Quite High
substance P 24 79.96 Quite High
Neuropeptide 6 59.28 Quite High
cytokine 11 56.96 Quite High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 19 100.00 Very High Very High Very High
Pancreatitis 539 99.82 Very High Very High Very High
Targeted Disruption 77 98.22 Very High Very High Very High
Pancreatic Cancer 65 97.28 Very High Very High Very High
Abdominal Pain 10 94.68 High High
Diabetes Mellitus 33 91.68 High High
Dislocations 1 91.36 High High
Body Weight 2 80.40 Quite High
Hypercalcemia 8 69.56 Quite High
Hyperlipidemia 4 66.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The indication for PRSS1 and SPINK1 mutation testing in symptomatic patients should be one of the following:
Positive_regulation (indication) of Gene_expression (testing) of PRSS1
1) Confidence 0.49 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.89 Pain Relevance 0.28
N29I and enhanced trypsinogen autoactivation
Positive_regulation (enhanced) of Gene_expression (autoactivation) of trypsinogen
2) Confidence 0.49 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.21 Pain Relevance 0
The indication for PRSS1 and SPINK1 mutation testing in symptomatic patients should be one of the following:
Positive_regulation (for) of Gene_expression (testing) of PRSS1
3) Confidence 0.49 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.89 Pain Relevance 0.28
R122H and increased trypsin stability
Positive_regulation (increased) of Gene_expression (stability) of trypsin
4) Confidence 0.49 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.60 Pain Relevance 0.15
A transgenic and control group, four mice each, were fed a protein rich diet for 6 weeks in order to stimulate trypsin synthesis by the pancreas.
Positive_regulation (stimulate) of Gene_expression (synthesis) of trypsin in pancreas associated with targeted disruption
5) Confidence 0.23 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1637108 Disease Relevance 0.66 Pain Relevance 0.03
The effect of trypsin in dog plasma does not end abruptly as in humans.
Positive_regulation (effect) of Gene_expression (effect) of trypsin in plasma
6) Confidence 0.15 Published 1982 Journal Clin Exp Hypertens A Section Abstract Doc Link 6756692 Disease Relevance 0 Pain Relevance 0
[Diagnosis of a "hereditary pancreatitis" by the detection of a mutation in the cationic trypsinogen gene].
Positive_regulation (mutation) of Gene_expression (detection) of trypsinogen gene associated with pancreatitis
7) Confidence 0.08 Published 1998 Journal Dtsch. Med. Wochenschr. Section Title Doc Link 9581160 Disease Relevance 0.47 Pain Relevance 0.26
To this end, expression of the rate-limiting enzymes in catecholamine (TyrH), serotonin (TrypH) and GABA (GAD) biosynthesis, as well as the vesicular acetylcholine transporter (VAChT), were examined in uninduced (D0) and induced (D6 and D12) MSCs (Fig. 2A).
Positive_regulation (induced) of Spec (examined) Gene_expression (expression) of TrypH associated with gaba, catecholamine and serotonin
8) Confidence 0.01 Published 2008 Journal Biological Procedures Online Section Body Doc Link PMC2683550 Disease Relevance 0.35 Pain Relevance 0.73

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