INT4570

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Context Info
Confidence 0.39
First Reported 1975
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.09
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Drd3) signal transducer activity (Drd3)
Anatomy Link Frequency
ventral 1
Drd3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 4 98.40 Very High Very High Very High
Clonidine 2 97.64 Very High Very High Very High
fluoxetine 1 97.00 Very High Very High Very High
Serotonin 1 94.04 High High
substance P 3 92.68 High High
Nucleus accumbens 4 88.68 High High
antagonist 1 81.28 Quite High
Dopamine 2 78.72 Quite High
Enkephalin 5 76.24 Quite High
Potency 2 75.20 Quite High
Disease Link Frequency Relevance Heat
Stress 1 92.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with spiroperidol, a dopaminergic receptor blocker, prevented the recovery induced by all agonists, although clonidine-induced recovery was affected least.
Negative_regulation (blocker) of dopaminergic receptor associated with agonist and clonidine
1) Confidence 0.39 Published 1975 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1208631 Disease Relevance 0 Pain Relevance 0.37
This descriptive study identified none of these three peptides as a single and specific target for dopaminergic receptor blockade.
Negative_regulation (blockade) of dopaminergic receptor
2) Confidence 0.39 Published 1986 Journal Neuropsychobiology Section Abstract Doc Link 2441312 Disease Relevance 0 Pain Relevance 0.27
The differential reactivity of PPE mRNA to dopaminergic receptor blockade and to a lesion of dopaminergic neurones along the rostrocaudal axis of the ventral striatum is discussed.
Negative_regulation (blockade) of dopaminergic receptor in ventral
3) Confidence 0.36 Published 1993 Journal Neuroreport Section Abstract Doc Link 8513136 Disease Relevance 0 Pain Relevance 0.34
Diazepam administration also blunted the release of prolactin induced by dopaminergic receptor blockade following haloperidol, or by serotonergic receptor activation produced by fluoxetine, a serotonergic reuptake inhibitor plus 5-hydroxytryptophan, a serotonin precursor.
Negative_regulation (blockade) of dopaminergic receptor associated with serotonin and fluoxetine
4) Confidence 0.16 Published 1982 Journal Neuroendocrinology Section Abstract Doc Link 6979001 Disease Relevance 0.09 Pain Relevance 0.22

General Comments

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